INT8640

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 332
Total Number 335
Disease Relevance 377.84
Pain Relevance 22.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 18
blood 12
heart 11
coronary artery 6
fat 3
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1075 100.00 Very High Very High Very High
Angina 180 99.84 Very High Very High Very High
Migraine 27 99.64 Very High Very High Very High
spinal inflammation 79 99.20 Very High Very High Very High
Etanercept 55 99.18 Very High Very High Very High
Infliximab 112 98.90 Very High Very High Very High
Arthritis 54 98.78 Very High Very High Very High
Inflammation 674 98.74 Very High Very High Very High
Pain 218 98.64 Very High Very High Very High
tolerance 186 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 16325 100.00 Very High Very High Very High
Coronary Artery Disease 4340 100.00 Very High Very High Very High
Hypertriglyceridemia 1241 100.00 Very High Very High Very High
Rheumatoid Arthritis 1095 100.00 Very High Very High Very High
Calcification 36 100.00 Very High Very High Very High
Hyperlipidemia 1134 99.96 Very High Very High Very High
Coronary Heart Disease 263 99.92 Very High Very High Very High
Cv General 3 Under Development 345 99.84 Very High Very High Very High
Diabetes Mellitus 5597 99.82 Very High Very High Very High
Cardiovascular Disease 3688 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Torcetrapib was a CTEP inhibitor that produced increases in HDL-C of about 72% coupled with a further reduction of about 25% in LDL-C, when it was added to atorvastatin therapy.
Positive_regulation (increases) of HDL associated with disorder of lipid metabolism
1) Confidence 0.67 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.74 Pain Relevance 0
Policosanol significantly (p < 0.001) lowered total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) by 17.5% and 31.0%, respectively, and meanwhile increased (p < 0.01) high-density lipoprotein-cholesterol (HDL-C) levels by 31.5%.
Positive_regulation (increased) of HDL associated with disorder of lipid metabolism
2) Confidence 0.67 Published 2003 Journal Angiology Section Abstract Doc Link 12593493 Disease Relevance 0.67 Pain Relevance 0.07
It is still the most efficacious drug in terms of its ability to increase HDL cholesterol content accompanied by a decrease in all atherogenic lipoproteins (VLDL, LDL, and L(a)) as well as fatty acids and triglycerides.
Positive_regulation (increase) of HDL associated with disorder of lipid metabolism
3) Confidence 0.67 Published 2007 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 17554232 Disease Relevance 0.71 Pain Relevance 0.08
With elevation of HDL values there is reduction in hsCRP values in patients with no significant coronary artery disease.
Positive_regulation (elevation) of HDL in coronary artery associated with coronary artery disease and disorder of lipid metabolism
4) Confidence 0.67 Published 2007 Journal Med Arh Section Abstract Doc Link 18232274 Disease Relevance 1.43 Pain Relevance 0
A study involving rabbits demonstrated a reduction in circulating TC and an increase in HDL-C upon virgin olive oil consumption.
Positive_regulation (increase) of HDL associated with disorder of lipid metabolism
5) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.90 Pain Relevance 0
An increase in HDL-C was also noted with increasing phenolic concentration of the oil [25].
Positive_regulation (increase) of HDL associated with disorder of lipid metabolism
6) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 1.10 Pain Relevance 0.05
The LPLSer(447)X variant is associated with decreased levels of plasma TGs and increased HDL cholesterol concentrations compared with wild-type LPL.
Positive_regulation (increased) of HDL in plasma associated with disorder of lipid metabolism
7) Confidence 0.67 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.60 Pain Relevance 0.09
Among non-diabetic men, all lipid measures, except for TG, were independent predictors for CVD; a 1 SD increase in HDL-C however, significantly decreased the risk of CVD, with almost same discriminatory power.
Positive_regulation (increase) of HDL associated with hypertriglyceridemia, cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
8) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.60 Pain Relevance 0
A 1 SD increase of HDL-C decreased risk of CVD by 17% in both models in non-diabetic men.
Positive_regulation (increase) of HDL associated with diabetes mellitus, cardiovascular disease and disorder of lipid metabolism
9) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.93 Pain Relevance 0
There was a significant increase in high-density lipoprotein-c (HDL-c) in women on DSG-EE.
Positive_regulation (increase) of HDL associated with disorder of lipid metabolism
10) Confidence 0.67 Published 1992 Journal Adv Contracept Deliv Syst Section Abstract Doc Link 12285566 Disease Relevance 0.37 Pain Relevance 0.09
Lovastatin treatment was associated with statistically significant decreases in LDL-C and increases in HDL-C, and chronic long-term treatment with 20-40 mg/day lovastatin was well tolerated in women.
Positive_regulation (increases) of HDL associated with disorder of lipid metabolism
11) Confidence 0.67 Published 2001 Journal J Womens Health Gend Based Med Section Abstract Doc Link 11788107 Disease Relevance 0.35 Pain Relevance 0
Via an improvement in glucose tolerance, ACE-inhibitors can contribute to a lowering of triglyceride concentrations and an increase in the HDL cholesterol levels.
Positive_regulation (increase) of HDL associated with tolerance, disorder of lipid metabolism and impaired glucose tolerance
12) Confidence 0.67 Published 1993 Journal Fortschr. Med. Section Abstract Doc Link 8449471 Disease Relevance 0.35 Pain Relevance 0.12
Whereas the reductase inhibitors and bile acid binding resins primarily affect LDL-C, the combined therapy has a synergistic effect to reduce LDL-C and, in addition, the niacin reduces triglycerides and increases HDL-C.
Positive_regulation (increases) of HDL in bile associated with bile and disorder of lipid metabolism
13) Confidence 0.67 Published 1996 Journal Coron. Artery Dis. Section Abstract Doc Link 8853585 Disease Relevance 1.43 Pain Relevance 0.18
Sustained-release niacin may be associated with more dramatic changes in LDL-C and triglyceride, whereas the short acting preparation causes greater increases in HDL-C.
Positive_regulation (increases) of HDL associated with disorder of lipid metabolism
14) Confidence 0.67 Published 1996 Journal Coron. Artery Dis. Section Abstract Doc Link 8853585 Disease Relevance 0.84 Pain Relevance 0.07
The increase of HDL-C occurs at a lower dose (1500 mg/day) than the reduction of LDL-C (> 1500 mg/day).
Positive_regulation (increase) of HDL associated with disorder of lipid metabolism
15) Confidence 0.67 Published 1996 Journal Coron. Artery Dis. Section Abstract Doc Link 8853585 Disease Relevance 0.84 Pain Relevance 0.07
Formulations containing these progestins lower LDL cholesterol and increase HDL cholesterol; they do not affect carbohydrate metabolism as much as older, more androgenic formulations.
Positive_regulation (increase) of HDL associated with disorder of lipid metabolism
16) Confidence 0.67 Published 1997 Journal Int J Fertil Womens Med Section Abstract Doc Link 9168375 Disease Relevance 0.73 Pain Relevance 0.13
Thus, the effect of increased HDL-C levels caused by partial deficiency of CETP is insufficient to prevent CHD in FH.
Positive_regulation (increased) of HDL associated with coronary artery disease, hyperlipoproteinemia type ii and disorder of lipid metabolism
17) Confidence 0.67 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9242969 Disease Relevance 1.84 Pain Relevance 0.09
In ASCOT-LLA, over 10,000 men and women without heart disease were given atorvastatin 10 mg versus placebo.14 The dose of atorvastatin used produced a 36% reduction in LDL-C but did not lead to an increase in HDL-C as we had seen in all the previous statin studies.
Positive_regulation (increase) of HDL in heart associated with heart disease and disorder of lipid metabolism
18) Confidence 0.67 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.94 Pain Relevance 0.03
After eight weeks of administration of cilostazol to patients with IC, walking distances were increased, associated with a 29% decrease in plasma triglycerides and a 13% increase in HDL-C.
Positive_regulation (increase) of HDL in plasma associated with restless leg syndrome and disorder of lipid metabolism
19) Confidence 0.67 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11583728 Disease Relevance 0.71 Pain Relevance 0.46
The increased plasma 11-DH-TXB2 levels indicated that there was platelet activation, followed by platelet aggregation and Kupffer cells phagocytosis.
Positive_regulation (increased) of 11-DH in platelet
20) Confidence 0.67 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434752 Disease Relevance 1.41 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox