INT86411

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 17.60
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
joints 2
nerve 2
vagus nerve 2
temporomandibular joint 2
microglia 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 311 100.00 Very High Very High Very High
Infliximab 132 100.00 Very High Very High Very High
Adalimumab 114 100.00 Very High Very High Very High
metalloproteinase 10 100.00 Very High Very High Very High
vagus nerve 9 99.84 Very High Very High Very High
Eae 9 99.76 Very High Very High Very High
nMDA receptor antagonist 1 99.68 Very High Very High Very High
Arthritis 194 99.66 Very High Very High Very High
Snapping jaw 2 99.48 Very High Very High Very High
Inflammatory mediators 11 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 345 100.00 Very High Very High Very High
Cancer 113 100.00 Very High Very High Very High
Necrosis 63 100.00 Very High Very High Very High
Diabetes Mellitus 22 100.00 Very High Very High Very High
Renal Disease 19 100.00 Very High Very High Very High
Nicotine Addiction 5 100.00 Very High Very High Very High
Hypertension 2 100.00 Very High Very High Very High
Thrombosis 4 99.96 Very High Very High Very High
Systemic Lupus Erythematosus 66 99.78 Very High Very High Very High
Injury 66 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A substantial number of these patients achieved partial remission, indicating that TNF inhibitors such as adalimumab may be more effective in patients with early disease and shorter disease duration.
Negative_regulation (effective) of Negative_regulation (inhibitors) of TNF associated with adalimumab and disease
1) Confidence 0.42 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012440 Disease Relevance 0.63 Pain Relevance 0.81
Although TNF inhibitors have been generally effective in polyarticular JIA and ERA, they have been less so in SOJIA (Billiau et al 2002; Russo et al 2002; Katsicas and Russo 2005; Kimura et al 2005).
Negative_regulation (effective) of Negative_regulation (inhibitors) of TNF associated with arthritis
2) Confidence 0.41 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721362 Disease Relevance 0.65 Pain Relevance 0.35
Models performed in all subjects and separately for each complication showed a tendency toward a negative confounding effect of both age and diabetes duration (increasing ORs from model 1 to model 2) and a positive confounding effect of A1C, hypertension, smoking, and TNF-?
Negative_regulation (showed) of Negative_regulation (effect) of TNF associated with nicotine addiction, diabetes mellitus and hypertension
3) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 0.84 Pain Relevance 0
This report stresses the importance of maintaining a high index of suspicion for unusual pathogens while managing patients receiving TNF-alpha inhibitors, particularly when used in combination with other immunosuppressants.
Negative_regulation (receiving) of Negative_regulation (inhibitors) of TNF-alpha associated with stress
4) Confidence 0.41 Published 2010 Journal J Drugs Dermatol Section Abstract Doc Link 20120426 Disease Relevance 1.17 Pain Relevance 0.60
The second part of this paper deals with down-regulation of TNF-alpha by a wide variety of cancer preventive agents.
Negative_regulation (down) of Negative_regulation (regulation) of TNF-alpha associated with cancer
5) Confidence 0.41 Published 2002 Journal Mech. Ageing Dev. Section Abstract Doc Link 12470903 Disease Relevance 1.28 Pain Relevance 0.42
to zero mimics sTNF deletion/depletion, while tmTNF deletion/depletion is obtained by setting ?
Negative_regulation (depletion) of Negative_regulation (deletion) of tmTNF
6) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.61 Pain Relevance 0.04
to zero mimics sTNF deletion/depletion, while tmTNF deletion/depletion is obtained by setting ?
Negative_regulation (deletion) of Negative_regulation (depletion) of tmTNF
7) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.61 Pain Relevance 0.04
to zero mimics sTNF deletion/depletion, while tmTNF deletion/depletion is obtained by setting ?
Negative_regulation (deletion) of Negative_regulation (depletion) of sTNF
8) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.56 Pain Relevance 0.04
to zero mimics sTNF deletion/depletion, while tmTNF deletion/depletion is obtained by setting ?
Negative_regulation (depletion) of Negative_regulation (deletion) of sTNF
9) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.56 Pain Relevance 0.04
[The inhibitory effect of hydroprednisolone on tumor necrosis factor in rabbits' temporomandibular joint disturbance syndrome].
Negative_regulation (inhibitory) of Negative_regulation (effect) of tumor necrosis factor in temporomandibular joint associated with necrosis, snapping jaw, syndrome and cancer
10) Confidence 0.37 Published 1997 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Title Doc Link 10677957 Disease Relevance 0.59 Pain Relevance 0.19
Secondary to inhibition of TNFalpha, infliximab reduces serum levels of inflammatory mediators and vascular endothelial growth factor, decreases the expression of chemokines in the synovial tissue and reduces lymphocyte migration into the joints of patients with rheumatoid arthritis.
Negative_regulation (reduces) of Negative_regulation (inhibition) of TNFalpha in joints associated with chemokine, inflammatory mediators, infliximab and rheumatoid arthritis
11) Confidence 0.37 Published 2000 Journal Drugs Section Abstract Doc Link 10882166 Disease Relevance 0.52 Pain Relevance 0.48
Drug-induced lupus and lupus nephritis under tumor necrosis factor blockade
Negative_regulation (nephritis) of Negative_regulation (blockade) of tumor necrosis factor associated with necrosis, cancer, renal disease and systemic lupus erythematosus
12) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374473 Disease Relevance 1.40 Pain Relevance 0.15
Surgical sectioning of the common celiac nerve abolishes the TNF suppression by vagus nerve stimulation, suggesting that the cholinergic pathway is functionally connected to the spleen via this branch of the vagus nerve.
Negative_regulation (abolishes) of Negative_regulation (suppression) of TNF in vagus nerve associated with vagus nerve
13) Confidence 0.29 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2902015 Disease Relevance 0.72 Pain Relevance 0.71
TNF receptors can also be shed, binding to soluble TNF-?
Negative_regulation (shed) of Negative_regulation (receptors) of TNF
14) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.81 Pain Relevance 0.21
Additionally, studies show that selective inhibition of TNFa prevents thrombus formation, intraneural edema, and a reduction in porcine nerve root conduction velocity [45].
Negative_regulation (prevents) of Negative_regulation (inhibition) of TNFa in nerve associated with pressure and volume under development and thrombosis
15) Confidence 0.17 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684219 Disease Relevance 1.01 Pain Relevance 0.62
Both agents effectively reversed PAR2 mediated disruption of TNF?
Negative_regulation (reversed) of Negative_regulation (disruption) of TNF
16) Confidence 0.16 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
However pre-treatment of the cells with YM254890 resulted in almost complete abrogation of peptide mediated inhibition of TNF?
Negative_regulation (abrogation) of Negative_regulation (inhibition) of TNF
17) Confidence 0.16 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
Whilst in this present study we show that K-14585 is able to reverse PAR2 mediated inhibition of TNF?
Negative_regulation (reverse) of Negative_regulation (inhibition) of TNF
18) Confidence 0.16 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.36
We confirmed that microglial CBR2 activation reduces TNF expression [11,16] and ERK dephosphorylation results in a significant reduction of TNF in primary microglia [21].
Negative_regulation (reduces) of Negative_regulation (reduction) of TNF in microglia
19) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.42 Pain Relevance 0.36
1 orally significantly reduced inflammatory changes, partly through suppression of matrix metalloproteinase (MMP-9), tumour necrosis factor (TNF), and interleukin-?
Negative_regulation (reduced) of Negative_regulation (suppression) of TNF associated with necrosis, inflammation, cancer and metalloproteinase
20) Confidence 0.07 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3003978 Disease Relevance 1.94 Pain Relevance 0.34

General Comments

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