INT86437

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2011
Negated 8
Speculated 1
Reported most in Body
Documents 154
Total Number 155
Disease Relevance 121.22
Pain Relevance 29.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 11
blood 5
white blood cell 4
macrophages 3
plasma cell 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2803 100.00 Very High Very High Very High
cytokine 2100 100.00 Very High Very High Very High
Osteoarthritis 396 100.00 Very High Very High Very High
Inflammatory marker 225 100.00 Very High Very High Very High
depression 144 100.00 Very High Very High Very High
chemokine 132 100.00 Very High Very High Very High
cINOD 65 100.00 Very High Very High Very High
Inflammatory response 308 99.98 Very High Very High Very High
aspirin 43 99.76 Very High Very High Very High
rheumatoid arthritis 1011 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3466 100.00 Very High Very High Very High
Cancer 1304 100.00 Very High Very High Very High
Osteoarthritis 389 100.00 Very High Very High Very High
Coronary Heart Disease 362 100.00 Very High Very High Very High
Depression 223 100.00 Very High Very High Very High
Necrosis 202 100.00 Very High Very High Very High
Sepsis 199 100.00 Very High Very High Very High
Insulin Resistance 196 100.00 Very High Very High Very High
Metastasis 62 100.00 Very High Very High Very High
Leukemia 58 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Statistical significance of the difference in the strength of CHD association with IL-6 compared to other markers was determined from differences in the loge odds ratios per 2 SD increase in 2,000 bootstrap samples of the data [34].
IL-6 Binding (association) of associated with coronary heart disease
1) Confidence 0.48 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2288623 Disease Relevance 0.30 Pain Relevance 0.03
In our study of young healthy subjects, we found that cumulative exposure to pollution over longer periods of time (3–6 days) was associated with the strongest associations with elevated IL-6.
IL-6 Binding (associations) of
2) Confidence 0.47 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.60 Pain Relevance 0.17
In exploratory analyses, we observed a possible interaction among anti-inflammatory drugs, interleukin-6 -174 C/C genotype, and longevity.
interleukin-6 Binding (interaction) of associated with aging, inflammation and cinod
3) Confidence 0.47 Published 2005 Journal Atherosclerosis Section Abstract Doc Link 15939070 Disease Relevance 0.69 Pain Relevance 0.20
Following extensive washing, bound IL-6 was detected using an HRP-conjugated polyclonal antibody against the target protein.
IL-6 Binding (bound) of
4) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 0.08 Pain Relevance 0
Tocilizumab, previously known as myeloma receptor antibody (MRA), is a humanized, IgG1 IL-6 receptor monoclonal antibody that binds with high affinity to the 80 kDa component of IL-6R.
IL-6 Binding (binds) of
5) Confidence 0.43 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.36 Pain Relevance 0.13
Newer therapies will include delivering by gene therapy or gene modulation variations and/or modifications of the interleukin-6 gene associated with decreased or absent IL-6 production.
interleukin-6 gene Binding (associated) of
6) Confidence 0.41 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.96 Pain Relevance 0.15
enhanced associations with CRP, IL-6, and WBCs.
IL-6 Binding (associations) of
7) Confidence 0.40 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1513328 Disease Relevance 1.52 Pain Relevance 0.15
IL-6 levels were inversely associated with total cholesterol concentrations (p < 0.01).
IL-6 Binding (associated) of associated with disorder of lipid metabolism
8) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2288623 Disease Relevance 0.96 Pain Relevance 0.09
In addition, human recombinant IL-6 has been shown to enhance human recombinant IL-1?
IL-6 Binding (recombinant) of
9) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.98 Pain Relevance 0.47
Our findings do not suggest an association between the development of asymptomatic DIP OA and the IL-6 gene, because the risk of radiographic OA was not affected by the IL-6 genotype.
IL-6 Neg (not) Binding (association) of associated with osteoarthritis
10) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.88 Pain Relevance 0.41
Tocilizumab inhibits the induction of biological activity due to IL-6 in cells that have expressed both membrane-bound IL-6R and gp130 molecules, and also inhibits the induction of biological activity due to IL-6/IL-6R complex formation in cells that express gp130 alone.
IL-6 Binding (formation) of
11) Confidence 0.37 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.40 Pain Relevance 0.13
IL-6 forms a complex by binding to IL-6 R on the cell membrane, which then combines with gp130, which also resides on the cell membrane, forming a homodimer and giving rise to intracellular signal transduction.
IL-6 Binding (binding) of
12) Confidence 0.37 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.42 Pain Relevance 0.25
There is evidence that muscular modifications appear to be associated with high levels of pro-inflammatory cytokines, especially IL-6 and TNF-?
IL-6 Binding (associated) of associated with inflammation and cytokine
13) Confidence 0.37 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.85 Pain Relevance 0.39
[Syndrome of inappropriate antidiuretic hormone secretion associated with meningeal infiltration of tumor cells and elevated interleukin-1 beta and interleukin-6 in cerebrospinal fluid of a patient with adult T-cell leukemia].
interleukin-6 Binding (associated) of in cerebrospinal fluid associated with leukemia, cancer and syndrome
14) Confidence 0.36 Published 2000 Journal Rinsho Ketsueki Section Title Doc Link 10723244 Disease Relevance 1.04 Pain Relevance 0.22
We observed the strongest association between IL-6 and O3 using the 4-day moving average: a 0.31 SD increase in IL-6 per O3 IQR [95% confidence interval (CI), 0.08–0.54].
IL-6 Binding (association) of
15) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0 Pain Relevance 0
At baseline, venous blood sample were taken after an overnight fast for DNA extraction, white blood cell immortalisation, measurement of plasma c-reactive protein, fibrinogen, interleukin-6, tissue necrosis factor-?
interleukin-6 Binding (fibrinogen) of in white blood cell associated with necrosis
16) Confidence 0.36 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2621220 Disease Relevance 0.51 Pain Relevance 0.07
At baseline, venous blood sample were taken after an overnight fast for DNA extraction, white blood cell immortalisation, measurement of plasma c-reactive protein, fibrinogen, interleukin-6, tissue necrosis factor-?
interleukin-6 Binding (extraction) of in white blood cell associated with necrosis
17) Confidence 0.36 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2621220 Disease Relevance 0.53 Pain Relevance 0.07
Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin.
IL6 Binding (associated) of associated with aspirin, cancer and cinod
18) Confidence 0.36 Published 2009 Journal Mutat. Res. Section Abstract Doc Link 18992263 Disease Relevance 1.58 Pain Relevance 0.72
mAb (10µg/ml) for Th2-polarizing conditions, or rhIL-6 (20ng/ml), rhIL-1?
IL-6 Binding (conditions) of
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.04
The polymorphisms IL6 G-174C, IL8 T-251A, PPARgamma2 Pro(12)Ala, IL1beta T-31C, and IL10 C-592A were not associated with risk of BCC.
IL6 Binding (associated) of associated with skin cancer
20) Confidence 0.36 Published 2007 Journal Mutat. Res. Section Abstract Doc Link 17307204 Disease Relevance 0.90 Pain Relevance 0.36

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