INT86446

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.52
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
lipid metabolic process (Lipg)
Anatomy Link Frequency
blood 1
Lipg (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 18 99.36 Very High Very High Very High
depression 38 95.28 Very High Very High Very High
pruritus 3 95.10 Very High Very High Very High
tolerance 2 93.36 High High
Opioid 1 91.92 High High
Cannabinoid 11 91.44 High High
Analgesic 4 90.24 High High
Cannabinoid receptor 7 86.16 High High
agonist 9 84.00 Quite High
Physical dependence 1 73.68 Quite High
Disease Link Frequency Relevance Heat
Hemolysis 1 99.92 Very High Very High Very High
Congenital Anomalies 5 98.48 Very High Very High Very High
Depression 38 95.28 Very High Very High Very High
Pruritus 3 95.10 Very High Very High Very High
Exanthema 3 94.84 High High
Hyperbilirubinemia 3 92.84 High High
Weight Gain 2 90.52 High High
Heart Rate Under Development 4 90.20 High High
Pressure And Volume Under Development 9 90.00 High High
Hypotension 7 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that a similar form of functional antagonism was produced by sustained inactivation of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol.
Protein_catabolism (degradative) of lipase associated with endocannabinoid
1) Confidence 0.50 Published 2010 Journal Nat. Neurosci. Section Abstract Doc Link 20729846 Disease Relevance 0.07 Pain Relevance 0.72
These findings are interpreted to indicate that exogenous 2-AG is rapidly degraded in mouse blood, probably by a lipase, which masks its ability to interact with CB1 receptors.
Protein_catabolism (degraded) of lipase in blood
2) Confidence 0.44 Published 2000 Journal Hypertension Section Abstract Doc Link 10679517 Disease Relevance 0.70 Pain Relevance 0.06
Grade 3–4 elevations of lipase occurred in 5% of patients and grade 3 elevation of amylase level was reported in 1 patient.
Protein_catabolism (Grade) of lipase
3) Confidence 0.20 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.78 Pain Relevance 0
The frequency of both appeared to increase with nilotinib dose.25 Rash and pruritus were the most common nonhematologic adverse events (20% and 15% of patients, respectively), but were almost all grade 1 or 2.25 The most common laboratory abnormalities were elevations in bilirubin (7% grade 1 or 2, 7% grade 3 or 4), increased lipase (5% grade 3 or 4), and increased aspartate transaminase (AST) and/or alanine transaminase (ALT) (1% grade 1 or 2 and 3% grade 3 or 4).25 The frequency and grade of bilirubin elevations increased with nilotinib dose, but these rises were generally self-limiting and resolved with continued administration of nilotinib.25 Analysis of electrocardiograms (ECGs) indicated one instance of increased QTcF (5–15 msec).
Protein_catabolism (grade) of lipase associated with exanthema, congenital anomalies and pruritus
4) Confidence 0.11 Published 2010 Journal Core evidence Section Body Doc Link PMC2899790 Disease Relevance 0.69 Pain Relevance 0.05
Only after dilution of the mTHPC-loaded mPEG750-b-OCL5-Bz micelles to polymer concentrations below the CAC or after micelle degradation by lipase, the released mTHPC can be taken up by 14C cells and exert its cytotoxic effect upon illumination, as schematically shown in Fig. 7.
Protein_catabolism (degradation) of lipase
5) Confidence 0.07 Published 2008 Journal Pharm Res Section Body Doc Link PMC2515570 Disease Relevance 0.14 Pain Relevance 0
To study the in vitro photocytotoxicity and cellular uptake of biodegradable polymeric micelles loaded with the photosensitizer mTHPC, including the effect of lipase-catalyzed micelle degradation.


Protein_catabolism (degradation) of lipase
6) Confidence 0.05 Published 2008 Journal Pharm Res Section Abstract Doc Link PMC2515570 Disease Relevance 0.08 Pain Relevance 0
After dilution of the micelles below the critical aggregation concentration (CAC), or after micelle degradation by lipase, photocytotoxicity and cellular uptake of mTHPC were restored.


Protein_catabolism (degradation) of lipase
7) Confidence 0.05 Published 2008 Journal Pharm Res Section Abstract Doc Link PMC2515570 Disease Relevance 0.08 Pain Relevance 0
We next took advantage of the recent development of specific inhibitors of the enzyme degrading 2-AG, Monoacyl Glycerol lipase [39], [40].
Protein_catabolism (degrading) of Glycerol lipase
8) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.76 Pain Relevance 0.42
Some commercial, unspecific, crude enzymes, such as cellulose, lysozyme, papain and lipase, also degrade chitin due to the presence of endo- and exochitinase in crude enzyme preparations [69–71].
Protein_catabolism (degrade) of lipase
9) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.22 Pain Relevance 0

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