INT86460

Context Info Confidence 0.04 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.80 Pain Relevance 2.08

Anatomy Link Frequency synaptic vesicles 1 Slc37a4 (Mus musculus)

Pain Link Frequency Relevance Heat monoamine 18 100.00 Dopamine 268 99.98 cINOD 3 99.06 Serotonin 7 98.92 Dynorphin 2 91.76 substance P 2 90.64 Enkephalin 2 88.60 dopamine receptor 5 86.72 addiction 21 81.40 depression 1 80.20

Disease Link Frequency Relevance Heat INFLAMMATION 3 98.94 Depression 1 80.20 Injury 2 79.28 Disease 1 79.20 Basal Ganglia Disease 2 78.04 Myoclonus 1 76.44 Attention Deficit Hyperactivity Disorder 1 73.88 Sprains And Strains 94 67.64 Targeted Disruption 11 65.96 Stress 7 64.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This complex interaction results in transporter-dependent efflux of monoamines into extracellular space from intraneuronal stores [10,38,39].

transporter Binding (interaction) of associated with monoamine

1) Confidence 0.04 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.11 Pain Relevance 0.62

In addition, once in the cell, amphetamines interfere with the vesicular monoamine transporter, depleting synaptic vesicles.

transporter Binding (interfere) of in synaptic vesicles associated with monoamine

2) Confidence 0.02 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0.32 Pain Relevance 0.74

Autoradiographic quantitation also showed a 30% increase in striatal dopamine transporter binding.

transporter Binding (binding) of associated with dopamine

3) Confidence 0.01 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682710 Disease Relevance 0.56 Pain Relevance 0.50

In contrast to these drugs, non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen, and fenoprofen interact with the transporter but do not serve as transportable substrates (35).

transporter Binding (interact) of associated with inflammation and cinod

4) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0.28 Pain Relevance 0.21

This finding establishes a link between the phosphate binding ABC transporter and the Hxc system in P. aeruginosa.

transporter Binding (binding) of

5) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242829 Disease Relevance 0.53 Pain Relevance 0

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