INT86462

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.86
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neuronal 2
substantia nigra 1
striatum 1
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 20 100.00 Very High Very High Very High
dopamine receptor 14 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Dopamine 498 99.36 Very High Very High Very High
Substantia nigra 31 95.28 Very High Very High Very High
Enkephalin 8 95.04 Very High Very High Very High
midbrain 66 94.44 High High
Serotonin 31 88.28 High High
monoamine 14 86.08 High High
projection neuron 3 77.44 Quite High
Disease Link Frequency Relevance Heat
Disease 16 99.04 Very High Very High Very High
Basal Ganglia Disease 2 97.88 Very High Very High Very High
Myoclonus 1 96.28 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 164 93.72 High High
Hypertrophy 9 87.32 High High
Cv Unclassified Under Development 1 86.96 High High
Diphtheria 1 81.88 Quite High
Targeted Disruption 22 77.04 Quite High
Cognitive Disorder 12 75.84 Quite High
Hypoxia 4 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal mRNA levels for PPE, PDyn, and DRD1 and DRD2 receptors revealed a significant change in the expression of markers present in medium spiny neurons projecting to the substantia nigra (direct pathway).
Transcription (levels) of DRD1 in substantia nigra associated with substantia nigra
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.37
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
Transcription (levels) of DRD1 in neuronal associated with dopamine receptor
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.44
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
Transcription (levels) of Striatal dopamine receptor D1 in neuronal associated with dopamine receptor
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.44
However, DRD1 and DRD2 mRNA levels were increased in the striatum suggesting impaired release of dopamine [185].
Transcription (levels) of DRD1 in striatum associated with dopamine
4) Confidence 0.37 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.93 Pain Relevance 0.65
As expected, striatal D1 dopamine receptor, dynorphin and substance P transcripts were not detected by in situ hybridization but there was a 27% increase in striatal D2 dopamine receptor messenger RNA and a 65% increase in enkephalin messenger RNA expression.
Neg (not) Transcription (detected) of D1 dopamine receptor associated with dynorphin, dopamine receptor, enkephalin and substance p
5) Confidence 0.21 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682710 Disease Relevance 0.62 Pain Relevance 0.46

General Comments

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