INT86474

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.64
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
plasma 1
sciatic nerve 1
neurons 1
medulla oblongata 1
motoneurons 1
Fgf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 14 99.52 Very High Very High Very High
Sciatic nerve 11 98.08 Very High Very High Very High
substance P 3 96.36 Very High Very High Very High
Spinal cord 2 95.12 Very High Very High Very High
Enkephalin 6 88.12 High High
Neuropeptide 1 78.36 Quite High
Peripheral nerve injury 2 75.00 Quite High
Root ganglion neuron 2 75.00 Quite High
neuralgia 4 25.00 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 32 80.68 Quite High
Nervous System Injury 6 75.00 Quite High
Ganglion Cysts 2 75.00 Quite High
Vibrio Infection 6 68.72 Quite High
Paresis 2 66.60 Quite High
Hyperkinesis 1 61.72 Quite High
Cancer 1 23.68 Low Low
Metastasis 2 22.08 Low Low
Body Weight 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 8 days, aFGF was slightly downregulated in all regions studied, single motoneurons showed NT expression, while expression of GAL, SP, VIP, and NPY could be detected neither in controls nor in toxin-treated animals.
Negative_regulation (downregulated) of aFGF in motoneurons associated with substance p
1) Confidence 0.58 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683301 Disease Relevance 0.19 Pain Relevance 0.55
Immunohistochemistry revealed that FGF1 was localized to neurons.
Negative_regulation (localized) of FGF1 in neurons
2) Confidence 0.43 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1831852 Disease Relevance 0.15 Pain Relevance 0
Staining of medulla oblongata sections for FGF1 was abolished using the antibody preabsorbed with 10 µg/ml of FGF1.
Negative_regulation (abolished) of FGF1 in medulla oblongata associated with medulla
3) Confidence 0.43 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0 Pain Relevance 0.09
Over a period of 28 days after sciatic nerve transection, the array signals for FGF 2 and 7 were significantly increased in the DRGs, while FGF 13 decreased.
Negative_regulation (decreased) of FGF in sciatic nerve associated with sciatic nerve
4) Confidence 0.41 Published 2002 Journal Neuroreport Section Abstract Doc Link 12395088 Disease Relevance 0.15 Pain Relevance 0.12
FGF 13 immunoreactivity was also decreased.
Negative_regulation (decreased) of FGF
5) Confidence 0.41 Published 2002 Journal Neuroreport Section Abstract Doc Link 12395088 Disease Relevance 0.15 Pain Relevance 0.12
The results of Fujimoto's study [19] demonstrated that the FGF receptor was expressed on the plasma membrane of regenerating axons and that exogenously applied FGF bound to the basal lamina, indicating that the binding of FGF and to its receptor facilitates axon regeneration.
Negative_regulation (applied) of FGF in plasma
6) Confidence 0.16 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0

General Comments

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