INT86475

Context Info Confidence 0.28 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 12 Disease Relevance 1.83 Pain Relevance 5.11

generation of precursor metabolites and energy (ACAA1) small molecule metabolic process (ACAA1) peroxisome (ACAA1)

Anatomy Link Frequency medulla 2 pons 2 prefrontal 1 ACAA1 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 42 99.44 agonist 40 99.22 medulla 6 98.16 opioid receptor 28 96.52 Hippocampus 4 96.36 Cannabinoid receptor 2 92.88 mu opioid receptor 6 90.00 Serotonin 6 86.76 antinociception 14 84.32 tail-flick 4 82.48

Disease Link Frequency Relevance Heat Parkinson's Disease 18 88.32 Alzheimer's Dementia 546 83.44 Disease 60 78.92 Toxicity 30 62.80 Neurological Disease 6 32.24 Prostate Cancer 12 22.64 Reprotox - General 1 6 16.52 Hyperandrogenism 6 15.60 Myoma 6 14.56 Precocious Puberty 6 13.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The optimal conditions for guanosine 5'-(gamma-[(35)S]thio)triphosphate binding to human brain sections were established in post mortem samples of the prefrontal cortex, hippocampus, basal ganglia, brainstem and cerebellar cortex.

thio Binding (binding) of in prefrontal associated with medulla and hippocampus

1) Confidence 0.28 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683421 Disease Relevance 0 Pain Relevance 0.48

The blockage of agonist-stimulated guanosine 5'-(gamma-[(35)S]thio)triphosphate binding by selective antagonists verified that the effect was receptor mediated.

thio Binding (binding) of associated with antagonist and agonist

2) Confidence 0.28 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683421 Disease Relevance 0 Pain Relevance 0.75

-Syn in PBS as control were followed over a period of 30 d by Thio T binding.

Thio Binding (binding) of

3) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225439 Disease Relevance 0.16 Pain Relevance 0.03

All analogs were assayed for their capacity to form amyloids by time-resolved Thio T binding, CR binding, and EM.

Thio Binding (binding) of

4) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225439 Disease Relevance 0.29 Pain Relevance 0.10

There is no significant Thio T binding during the entire seeding experiment, which suggests that L20 fibrils are unable to seed wild-type GnRH.

Thio Binding (binding) of

5) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225439 Disease Relevance 0.41 Pain Relevance 0

With the exception of analog S10, there is no significant Thio T binding by short-acting analogs during the entire incubation period.

Thio Binding (binding) of

6) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225439 Disease Relevance 0.15 Pain Relevance 0

The fibril growth of the mixture as well as the wild-type GnRH alone (S12) and mature L20 fibrils was followed over a period of 1 mo by Thio T binding (Figure S7A).

Thio Binding (binding) of

7) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225439 Disease Relevance 0.41 Pain Relevance 0

Thio T binding.

Thio Binding (binding) of

8) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225439 Disease Relevance 0.41 Pain Relevance 0

TAN-821 stimulated the binding of the nonhydrolyzable guanosine 5'-triphosphate analog, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via the activation of putative epsilon opioid receptor.

gamma-thio Binding (binding) of in medulla associated with medulla and opioid receptor

9) Confidence 0.00 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15246090 Disease Relevance 0 Pain Relevance 0.82

TAN-821 stimulated binding of the non-hydrolyzable guanosine 5'-triphosphate analogue, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via activation of the epsilon receptor.

gamma-thio Binding (binding) of in medulla associated with medulla

10) Confidence 0.00 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 16719773 Disease Relevance 0 Pain Relevance 1.05

TAN-821 stimulated the binding of the nonhydrolyzable guanosine 5'-triphosphate analog, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via the activation of putative epsilon opioid receptor.

gamma-thio Binding (binding) of in pons associated with medulla and opioid receptor

11) Confidence 0.00 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15246090 Disease Relevance 0 Pain Relevance 0.82

TAN-821 stimulated binding of the non-hydrolyzable guanosine 5'-triphosphate analogue, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via activation of the epsilon receptor.

gamma-thio Binding (binding) of in pons associated with medulla

12) Confidence 0.00 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 16719773 Disease Relevance 0 Pain Relevance 1.05

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