INT86486

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.74
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna1) transmembrane transport (Kcna1)
Anatomy Link Frequency
brain 2
Kcna1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 23 100.00 Very High Very High Very High
tetrodotoxin 3 99.98 Very High Very High Very High
Hippocampus 18 94.96 High High
depression 3 94.00 High High
gABA 3 88.12 High High
Neuronal excitability 14 44.24 Quite Low
cerebral cortex 10 8.64 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 8 98.82 Very High Very High Very High
Convulsion 66 98.36 Very High Very High Very High
Sleep Disorders 28 96.00 Very High Very High Very High
Depression 3 94.00 High High
Targeted Disruption 98 55.68 Quite High
Attention Deficit Hyperactivity Disorder 6 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Myoclonus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Impairing secretion by clostridial neurotoxins or blocking activity by tetrodotoxin inhibited the expression of Kv1.1, Kv1.2, and Kv1.4, whereas the other Kv1 channels still appeared.
Negative_regulation (inhibited) of Gene_expression (expression) of Kv1 associated with tetrodotoxin
1) Confidence 0.55 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.37
Seizures and a reduced lifespan have also been described in Kcna1 null mice, in which the expression of the Kv1.1 subunit is abolished [18], as well as in Kcnab2 null mice [19], lacking the modulatory subunit beta 2, which co-distributes extensively with Kv1.1 and Kv1.2 in the adult rat brain [11].
Negative_regulation (abolished) of Gene_expression (expression) of Kv1 in brain associated with convulsion and lifespan
2) Confidence 0.42 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.82 Pain Relevance 0.05
In this study we confirmed that Kcna2 null mice, in which the expression of the voltage-dependent potassium channel alpha subunit Kv1.2 is completely abolished, die within the first 3–4 weeks because of an episode of generalized seizures [17].
Negative_regulation (abolished) of Gene_expression (expression) of Kv1 associated with convulsion and potassium channel
3) Confidence 0.42 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.64 Pain Relevance 0.05
Impairing secretion by clostridial neurotoxins or blocking activity by tetrodotoxin inhibited the expression of Kv1.1, Kv1.2, and Kv1.4, whereas the other Kv1 channels still appeared.
Negative_regulation (inhibited) of Gene_expression (expression) of Kv1 associated with tetrodotoxin
4) Confidence 0.40 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.37
Impairing secretion by clostridial neurotoxins or blocking activity by tetrodotoxin inhibited the expression of Kv1.1, Kv1.2, and Kv1.4, whereas the other Kv1 channels still appeared.
Negative_regulation (inhibited) of Gene_expression (expression) of Kv1 associated with tetrodotoxin
5) Confidence 0.40 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.37

General Comments

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