INT8650

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 3
Speculated 8
Reported most in Abstract
Documents 152
Total Number 160
Disease Relevance 61.97
Pain Relevance 81.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
neurons 18
spinal cord 12
dorsal root ganglion 12
IAST 9
hypothalamus 6
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 224 100.00 Very High Very High Very High
substance P 183 100.00 Very High Very High Very High
Neurotransmitter 139 100.00 Very High Very High Very High
Calcitonin gene-related peptide 118 100.00 Very High Very High Very High
Enkephalin 101 100.00 Very High Very High Very High
Somatostatin 67 100.00 Very High Very High Very High
Dorsal horn 40 100.00 Very High Very High Very High
Cholecystokinin 15 100.00 Very High Very High Very High
Kappa opioid receptor 14 100.00 Very High Very High Very High
intrathecal 55 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 195 100.00 Very High Very High Very High
Nervous System Injury 93 99.92 Very High Very High Very High
Urological Neuroanatomy 50 99.92 Very High Very High Very High
Targeted Disruption 93 99.88 Very High Very High Very High
Obesity 20 99.84 Very High Very High Very High
Injury 106 99.82 Very High Very High Very High
Nociception 80 99.78 Very High Very High Very High
Sprains And Strains 137 99.76 Very High Very High Very High
INFLAMMATION 166 99.72 Very High Very High Very High
Abdominal Pain 3 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential expression of galanin immunoreactivities in the primary sensory neurons following partial and complete sciatic nerve injuries.
Gene_expression (expression) of galanin in primary sensory neurons associated with nervous system injury and sciatic nerve
1) Confidence 0.78 Published 1997 Journal Neuroscience Section Title Doc Link 9219977 Disease Relevance 0.62 Pain Relevance 0.62
We investigated the effects of partial sciatic nerve injuries on galanin expression in primary sensory neurons, and compared this effect with that after complete sciatic nerve injury.
Gene_expression (expression) of galanin in sciatic nerve associated with nervous system injury and sciatic nerve
2) Confidence 0.78 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219977 Disease Relevance 0.69 Pain Relevance 0.68
Galanin expression in primary sensory neurons seems to be differentially regulated following partial and complete sciatic nerve injuries.
Gene_expression (expression) of Galanin in primary sensory neurons associated with nervous system injury and sciatic nerve
3) Confidence 0.78 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219977 Disease Relevance 0.70 Pain Relevance 0.43
These results indicate that reduced food intake affects the expression of NPY, Gal and Leu-enk not only in the relevant hypothalamic neuroendocrine centres, but also in the lateral septal area.
Gene_expression (expression) of Gal in septal area
4) Confidence 0.77 Published 2005 Journal Acta. Biol. Hung. Section Abstract Doc Link 16196194 Disease Relevance 0 Pain Relevance 0.04
Rats given increasing ethanol concentrations, with 12 h access starting 4 h into the dark cycle, had a mean blood alcohol concentration of 18 mg/dl and exhibited a similar increase in GAL expression in the DMN and PVN. (4) Withdrawal from the opioid effects of 9% ethanol, produced by injection of naloxone (3 mg/kg sc), reversed this ethanol effect by significantly reducing GAL expression in the DMN and PLH below baseline levels.
Gene_expression (expression) of GAL in PLH associated with narcan, opioid, withdrawal and alcohol
5) Confidence 0.76 Published 2003 Journal Physiol. Behav. Section Abstract Doc Link 12818715 Disease Relevance 0 Pain Relevance 0.45
The results showed that IAST/GAL transfected with preprogalanin gene could express and secrete significantly higher level of GAL protein in vitro and in vivo as compared with control cells.
Gene_expression (transfected) of GAL in IAST
6) Confidence 0.75 Published 2010 Journal Eur J Pain Section Abstract Doc Link 20004601 Disease Relevance 1.05 Pain Relevance 1.05
We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar.
Gene_expression (expression) of GAL in PDL
7) Confidence 0.75 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12939349 Disease Relevance 0.09 Pain Relevance 0.17
Subarachnoid transplantation of immortalized galanin-overexpressing astrocytes attenuates chronic neuropathic pain.
Gene_expression (overexpressing) of galanin in astrocytes associated with neuralgia and neuropathic pain
8) Confidence 0.75 Published 2010 Journal Eur J Pain Section Title Doc Link 20004601 Disease Relevance 0.84 Pain Relevance 0.89
Here, the sensitivity to capsaicin and the expression of galanin were simultaneously examined by double-staining in individual, dissociated rat dorsal root ganglion neurons (1) after axotomy of the sciatic nerve for up to 14 days and (2) in culture for up to 4 days without prior nerve injury.
Gene_expression (expression) of galanin in dorsal root ganglion associated with ganglion cysts, nervous system injury, qutenza, root ganglion neuron and sciatic nerve
9) Confidence 0.75 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12955388 Disease Relevance 0.36 Pain Relevance 0.63
After axotomy, galaninergic neurons had a soma size-distribution profile similar to the capsaicin-sensitive neurons, but there was no colocalization of capsaicin sensitivity and galanin expression in individual neurons.
Gene_expression (expression) of galanin in neurons associated with qutenza
10) Confidence 0.75 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12955388 Disease Relevance 0.28 Pain Relevance 0.86
Low-grade chronic inflammation after an acute initial insult causes a persistent increase in the expression of galanin in the mucosa and SP in muscle layer.
Gene_expression (expression) of galanin in muscle associated with inflammation and substance p
11) Confidence 0.75 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18208479 Disease Relevance 0.56 Pain Relevance 0.46
Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis.
Gene_expression (expression) of galanin in enteric nerves associated with colitis and neuropeptide
12) Confidence 0.75 Published 2008 Journal Neurogastroenterol. Motil. Section Title Doc Link 18208479 Disease Relevance 0.69 Pain Relevance 0.49
No overlap of sensitivity to capsaicin and expression of galanin in rat dorsal root ganglion neurons after axotomy.
Gene_expression (expression) of galanin in dorsal root ganglion associated with ganglion cysts, qutenza and root ganglion neuron
13) Confidence 0.75 Published 2003 Journal Exp Brain Res Section Title Doc Link 12955388 Disease Relevance 0.36 Pain Relevance 0.86
Our findings suggest that RTX can cause changes (messenger plasticity) in galanin, VIP and NOS expression in capsaicin-sensitive sensory neurones of the rat, similar to those described following axotomy.
Gene_expression (expression) of galanin associated with qutenza
14) Confidence 0.75 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.19
Using in situ hybridization, the expression of mRNA encoding galanin, vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and nitric oxide synthase (NOS), respectively, was studied in lumbar dorsal root ganglia of rats given a single s.c. dose of 300 micrograms kg-1 resiniferatoxin (RTX), an ultrapotent capsaicin analogue.
Gene_expression (expression) of galanin in dorsal root ganglia associated with qutenza and neuropeptide
15) Confidence 0.75 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.14
In the present study, we assessed the effects of four manipulations that have been used to study development and maintenance of vibrissae-related patterns in the V system-nerve transection, whisker clipping, activity blockade with tetrodotoxin (TTX), and axoplasmic transport attenuation with vinblastine-upon the expression of galanin and NPY by V ganglion cells and their central axons in the V brainstem complex.
Gene_expression (expression) of galanin in ganglion cells associated with ganglion cysts, medulla and tetrodotoxin
16) Confidence 0.75 Published 1996 Journal Somatosens Mot Res Section Abstract Doc Link 8844957 Disease Relevance 0.26 Pain Relevance 0.48
These results show that galanin expression in DRGs and spinal cord is differentially regulated by different degrees of nerve constriction and further support its modulatory role on neuropathic pain.
Gene_expression (expression) of galanin in DRGs associated with neuropathic pain and spinal cord
17) Confidence 0.75 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 17693056 Disease Relevance 0.25 Pain Relevance 0.49
The decrease in binding results in the inability of galanin to inhibit the C fibers stimulation-induced facilitation of the rat flexor reflex, demonstrating that peptide-PNA constructs act in vivo to suppress expression of functional galanin receptors.
Gene_expression (expression) of galanin
18) Confidence 0.75 Published 1998 Journal Nat. Biotechnol. Section Abstract Doc Link 9743120 Disease Relevance 0.07 Pain Relevance 0.16
None of the neuropeptides and neuronal markers examined, including substance P, CGRP, galanin, neuropeptide Y, tyrosine hydroxylase, methionine-enkephalin, choline acetyltransferase and glially fibrilally acidic protein, was present in these c-Ret immunoreactive cells in the spinal cord.
Gene_expression (present) of galanin in spinal cord associated with neuropeptide, enkephalin, spinal cord and substance p
19) Confidence 0.75 Published 1999 Journal J. Chem. Neuroanat. Section Abstract Doc Link 10609865 Disease Relevance 0 Pain Relevance 0.38
The 33GAL.19 and 33V.1 cells transplanted in the lumbar subarachnoid space near the spinal cord one week after CCI, survived at least seven weeks on the pial surface around the spinal cord and only the 33GAL.19 cells expressed GAL-ir in vivo after transplant.
Gene_expression (expressed) of GAL in spinal cord associated with eae and spinal cord
20) Confidence 0.75 Published 1999 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 10642092 Disease Relevance 1.40 Pain Relevance 1.28

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