INT8652

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Context Info
Confidence 0.94
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.70
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
brain 2
testes 1
pituitary 1
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 35 100.00 Very High Very High Very High
Neuropeptide 6 99.96 Very High Very High Very High
Enkephalin 6 99.90 Very High Very High Very High
ischemia 3 99.04 Very High Very High Very High
Catecholamine 4 97.08 Very High Very High Very High
Inflammatory response 1 94.60 High High
Opioid 5 90.60 High High
opioid receptor 2 88.08 High High
Endogenous opioid 1 81.92 Quite High
substance P 8 80.16 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 4 99.96 Very High Very High Very High
Cv Unclassified Under Development 1 99.04 Very High Very High Very High
Reperfusion Injury 2 98.68 Very High Very High Very High
Disease 75 98.60 Very High Very High Very High
Diabetes Mellitus 10 97.16 Very High Very High Very High
Increased Venous Pressure Under Development 14 96.00 Very High Very High Very High
INFLAMMATION 1 94.60 High High
Left Ventricular Hypertrophy 6 93.20 High High
Myocardial Infarction 94 86.36 High High
Neurodegenerative Disease 4 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE inhibitors work by inhibiting kininase II and degradation of bradykinin which results in elevated levels of bradykinin.
Protein_catabolism (degradation) of kininase II associated with bradykinin
1) Confidence 0.94 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.92 Pain Relevance 0.27
Moreover, ACE is a major pathway for the degradation of bradykinin [8], a peptide of the kinin family involved in the regulation of vascular tone that also participates in the peripheral inflammatory response [9].
Protein_catabolism (degradation) of ACE associated with inflammatory response and bradykinin
2) Confidence 0.86 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2627518 Disease Relevance 1.48 Pain Relevance 0.29
Neutral endopeptidase 24.11 (NEP) and angiotensin-converting enzyme (ACE) degrade neuropeptides, including enkephalin and are expressed in the brain.
Protein_catabolism (degrade) of ACE in brain associated with neuropeptide and enkephalin
3) Confidence 0.72 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9630637 Disease Relevance 0.07 Pain Relevance 0.77
From these results, it was suggested that noxious stimuli on the pulp led to activation of trypsin-like enzymes followed by an increased content of met-EK-like peptides, and thereafter, the peptides, such as met-EK, might be degraded by angiotensin converting enzyme (ACE).
Protein_catabolism (degraded) of ACE
4) Confidence 0.72 Published 1983 Journal Life Sci. Section Abstract Doc Link 6363856 Disease Relevance 0 Pain Relevance 0.15
Vasopeptidase inhibitors inhibit ACE activity and neutral endopeptidase, which degrades natriuretic peptides.
Protein_catabolism (degrades) of ACE associated with natriuresis
5) Confidence 0.64 Published 2007 Journal Diabetes Section Abstract Doc Link 17259379 Disease Relevance 1.17 Pain Relevance 0.07
In addition the ACE is also responsible for the degradation of bradykinin which is a potent vasodilator (Goodfriend et al 1996).
Protein_catabolism (degradation) of ACE associated with bradykinin
6) Confidence 0.62 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.86 Pain Relevance 0.11
The cardioprotective effects produced by perfusion with BK or by reduction of BK degradation through local interference with ACE favor a role for BK in ischemia-reperfusion injuries in rats and dogs.
Protein_catabolism (degradation) of ACE associated with reperfusion injury, ischemia and bradykinin
7) Confidence 0.52 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1697370 Disease Relevance 0.20 Pain Relevance 0.63
Endopeptidase 24.15 (EC 3.4.24.15; EP 24.15), a zinc-metalloendopeptidase highly active in rat testes, brain and pituitary, converts some prodynorphin- and proenkephalin-derived oligopeptides into the corresponding enkephalins and degrades a variety of bioactive peptides including bradykinin, neurotensin, and both angiotensin I and II.
Protein_catabolism (degrades) of angiotensin I in brain associated with enkephalin and bradykinin
8) Confidence 0.15 Published 1992 Journal Brain Res. Section Abstract Doc Link 1377082 Disease Relevance 0 Pain Relevance 0.15
Endopeptidase 24.15 (EC 3.4.24.15; EP 24.15), a zinc-metalloendopeptidase highly active in rat testes, brain and pituitary, converts some prodynorphin- and proenkephalin-derived oligopeptides into the corresponding enkephalins and degrades a variety of bioactive peptides including bradykinin, neurotensin, and both angiotensin I and II.
Protein_catabolism (degrades) of angiotensin I in pituitary associated with enkephalin and bradykinin
9) Confidence 0.05 Published 1992 Journal Brain Res. Section Abstract Doc Link 1377082 Disease Relevance 0 Pain Relevance 0.15
Endopeptidase 24.15 (EC 3.4.24.15; EP 24.15), a zinc-metalloendopeptidase highly active in rat testes, brain and pituitary, converts some prodynorphin- and proenkephalin-derived oligopeptides into the corresponding enkephalins and degrades a variety of bioactive peptides including bradykinin, neurotensin, and both angiotensin I and II.
Protein_catabolism (degrades) of angiotensin I in testes associated with enkephalin and bradykinin
10) Confidence 0.05 Published 1992 Journal Brain Res. Section Abstract Doc Link 1377082 Disease Relevance 0 Pain Relevance 0.15

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