INT86534

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 81
Total Number 104
Disease Relevance 57.81
Pain Relevance 23.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14)
nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)
Anatomy Link Frequency
chondrocytes 9
annulus 3
fibroblasts 2
neurons 2
finger 1
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1141 100.00 Very High Very High Very High
cytokine 1190 99.98 Very High Very High Very High
Eae 10 99.72 Very High Very High Very High
metalloproteinase 181 99.66 Very High Very High Very High
Osteoarthritis 2749 99.40 Very High Very High Very High
Kinase C 32 99.20 Very High Very High Very High
Nicotine 192 99.12 Very High Very High Very High
Central nervous system 257 99.04 Very High Very High Very High
aspirin 22 98.98 Very High Very High Very High
IPN 8 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1208 100.00 Very High Very High Very High
Apoptosis 914 100.00 Very High Very High Very High
Stress 462 100.00 Very High Very High Very High
Death 200 99.92 Very High Very High Very High
Alzheimer's Dementia 36 99.76 Very High Very High Very High
Neurodegenerative Disease 48 99.60 Very High Very High Very High
Breast Cancer 112 99.52 Very High Very High Very High
Cold Sores 367 99.48 Very High Very High Very High
Osteoarthritis 2733 99.40 Very High Very High Very High
Aging 263 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium salicylate-induced apoptosis of human peripheral blood eosinophils is independent of the activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.
Positive_regulation (activation) of p38 in eosinophils associated with apoptosis
1) Confidence 0.62 Published 2000 Journal Int. Arch. Allergy Immunol. Section Title Doc Link 10686508 Disease Relevance 0.66 Pain Relevance 0.08
Secretion requires intracellular calcium mobilization and activation of phosphinositol-3 kinase and p38 mitogen activated kinase.
Positive_regulation (activation) of p38
2) Confidence 0.60 Published 2007 Journal Curr Rheumatol Rep Section Abstract Doc Link 18177605 Disease Relevance 0.48 Pain Relevance 1.18
The activation of inflammation-associated enzymes such as p38 mitogen-activated protein kinase (p38 MAPK) and cycloxygenase-2 (COX-2) is not restricted to glial cells but also found in neurons and may contribute to intraneuronal damage.
Positive_regulation (activation) of p38 mitogen-activated protein kinase in neurons associated with inflammation
3) Confidence 0.59 Published 2002 Journal Curr. Med. Chem. Section Abstract Doc Link 11860350 Disease Relevance 1.35 Pain Relevance 0.66
activates p38?
Positive_regulation (activates) of p38
4) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.02 Pain Relevance 0.45
-induced activation of p38-MAPK in human OA chondrocytes.
Positive_regulation (activation) of p38 in chondrocytes associated with osteoarthritis
5) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.55 Pain Relevance 0.28
-induced activation of p38-MAPK isoforms in human OA chondrocytes.
Positive_regulation (activation) of p38 in chondrocytes associated with osteoarthritis
6) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.66 Pain Relevance 0.33
-induced activation of p38?
Positive_regulation (activation) of p38
7) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.61 Pain Relevance 0.31
was more pronounced on the phosphorylation of MKK3 as compared to MKK6 suggesting that MKK3 may be the primary kinase involved in the activation of p38-MAPK in human OA chondrocytes.
Positive_regulation (activation) of p38 in chondrocytes associated with osteoarthritis
8) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30
-induced activation of p38-MAPK in human OA chondrocytes
Positive_regulation (activation) of p38 in chondrocytes associated with osteoarthritis
9) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.04 Pain Relevance 0.43
-induced activation of p38?
Positive_regulation (activation) of p38
10) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.06 Pain Relevance 0.57
For instance, MKK6 is the major activator of p38-MAPK in cells exposed to osmotic stress [13] and MKK3 is required for full activation of p38-MAPK in murine embryonic fibroblasts [38].
Positive_regulation (activation) of p38 in fibroblasts associated with stress
11) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.66 Pain Relevance 0.33
Our results demonstrate a novel mechanism of sulindac-induced apoptosis in human MM cells, namely, accumulation of p53, Bax, and Bak in mitochondria mediated by p38 MAPK activation downstream of ROS production.
Positive_regulation (activation) of p38 associated with multiple myeloma and apoptosis
12) Confidence 0.47 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.12 Pain Relevance 0
It could also activate c-Jun N-terminal kinase (JNK) and p38 MAPK but not extracellular signal-regulated protein kinase (ERK) activity within 1 h.
Positive_regulation (activate) of p38
13) Confidence 0.45 Published 2000 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 10686508 Disease Relevance 0.16 Pain Relevance 0
The activation of inflammation-associated enzymes such as p38 mitogen-activated protein kinase (p38 MAPK) and cycloxygenase-2 (COX-2) is not restricted to glial cells but also found in neurons and may contribute to intraneuronal damage.
Positive_regulation (activation) of p38 mitogen-activated protein kinase in neurons associated with inflammation
14) Confidence 0.42 Published 2002 Journal Curr. Med. Chem. Section Abstract Doc Link 11860350 Disease Relevance 1.35 Pain Relevance 0.66
-induced activation of p38-MAPK compared to the level noted in cells with knockdown expression of MKK6.
Positive_regulation (activation) of p38
15) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.54 Pain Relevance 0.27
-induced activation of p38-MAPK (Figure 2b, c), but the inhibition of phosphorylation was more pronounced when the expression of MKK3 was knocked down compared to the knockdown of MKK6 (Figure 2b).


Positive_regulation (activation) of p38
16) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.99 Pain Relevance 0.41
Key to these pathways are the evolutionarily conserved mitogen-activated protein kinases (MAPKs); of these, p38-MAPK (also known as MAPK14) has received considerable attention as potential therapeutic target for inflammatory and degenerative diseases such as OA [33]. p38-MAPK is thought to be crucial because selective p38-MAPK inhibitors block joint inflammation and destruction in several animal models of arthritis [12].
Positive_regulation (conserved) of p38 in joint associated with inflammation, disease, osteoarthritis and arthritis
17) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.06 Pain Relevance 0.56
-induced production of MMPs by blocking the activation of p38-MAPK and the transcription factor NF-?
Positive_regulation (activation) of p38 associated with metalloproteinase
18) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.92 Pain Relevance 0.55
Thus, treatment with PE affects particularly the activation of MKK3 which in turn has an impact on the activation of p38-MAPK downstream (summarized in Figure 6).
Positive_regulation (activation) of p38
19) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.68 Pain Relevance 0.25
CONCLUSION: There is no direct relationship between the activation of JNK and p38 MAPK pathways and NaSal-induced apoptosis in human peripheral blood eosinophils.


Positive_regulation (activation) of p38 in blood
20) Confidence 0.41 Published 2000 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 10686508 Disease Relevance 0.12 Pain Relevance 0

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