INT86539

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.18
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Anatomy Link Frequency
neurons 4
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 98.52 Very High Very High Very High
Hippocampus 2 97.60 Very High Very High Very High
long-term potentiation 10 96.52 Very High Very High Very High
central sensitization 26 95.44 Very High Very High Very High
antagonist 2 86.56 High High
Spinal cord 30 82.80 Quite High
qutenza 58 77.28 Quite High
nMDA receptor 2 66.80 Quite High
tetrodotoxin 2 61.76 Quite High
Kinase C 36 54.24 Quite High
Disease Link Frequency Relevance Heat
Nociception 34 92.88 High High
Pain 4 21.44 Low Low
Injury 2 20.48 Low Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation and activity of CaM kinase IV as well as CaM kinase II were increased by treatment of neurons either with glutamate or high K(+).
Positive_regulation (increased) of Phosphorylation (Phosphorylation) of CaM kinase II in neurons associated with glutamate
1) Confidence 0.55 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.30
We report the properties of phosphorylation and activation of CaM kinase IV in comparison to CaM kinase II in cultured rat hippocampal neurons.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of CaM kinase II in neurons
2) Confidence 0.40 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.24
Additionally, the coordinated phosphorylation of CREB was initiated by the rapid phosphorylation of MAP kinase, as well as other activated protein kinases, such as calcium/calmodulin protein-dependent kinase II (CaM kinase II), protein kinase A and C [6,9,17,22-24].
Positive_regulation (initiated) of Phosphorylation (phosphorylation) of kinase II
3) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.09 Pain Relevance 0.55
Additionally, the coordinated phosphorylation of CREB was initiated by the rapid phosphorylation of MAP kinase, as well as other activated protein kinases, such as calcium/calmodulin protein-dependent kinase II (CaM kinase II), protein kinase A and C [6,9,17,22-24].
Positive_regulation (initiated) of Phosphorylation (phosphorylation) of kinase II
4) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.09 Pain Relevance 0.55

General Comments

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