INT86541

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Context Info
Confidence 0.71
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.70
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Camk1g) plasma membrane (Camk1g) cytoplasm (Camk1g)
Anatomy Link Frequency
neuronal 3
neurons 3
Camk1g (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4 76.56 Quite High
nMDA receptor 3 75.00 Quite High
cerebral cortex 1 75.00 Quite High
Neurobehavioral 5 72.28 Quite High
antagonist 1 66.08 Quite High
Neurotransmitter 30 65.08 Quite High
monoamine 15 64.40 Quite High
tetrodotoxin 2 58.64 Quite High
Dopamine 20 58.52 Quite High
Serotonin 10 48.52 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 5 97.68 Very High Very High Very High
Poisoning 20 90.56 High High
Repression 10 61.12 Quite High
Urological Neuroanatomy 40 50.00 Quite Low
Stress 5 27.60 Quite Low
Drug Induced Neurotoxicity 15 5.00 Very Low Very Low Very Low
Neuroblastoma 10 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 10 5.00 Very Low Very Low Very Low
Shock 10 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both those studies, artificial knockdown or over-expression of Camk1g altered outgrowth of neuronal processes in a development context [80,81].
Gene_expression (over) of Camk1g in neuronal
1) Confidence 0.71 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.07 Pain Relevance 0
Overall, increased expression of c-fos, Egr1 and Camk1g in the present study are most likely regulated by pyrethroid-induced changes in the neuronal firing patterns of cortical neurons.
Gene_expression (expression) of Camk1g in neurons
2) Confidence 0.71 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.13 Pain Relevance 0.16
These observations support that pyrethroid-mediated changes in neuronal firing rates could mediate changes in the expression of Camk1g, which may in turn lead to changes in neuronal morphology (see below), especially during development.
Gene_expression (expression) of Camk1g in neuronal
3) Confidence 0.71 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
Data from in vitro models of developmental morphogenesis in neurons indicates that increased expression of Camk1g (Table 4 and Figure 4) may alter the structure and function of pyrethroid-sensitive neurons.
Gene_expression (expression) of Camk1g in neurons
4) Confidence 0.71 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.09 Pain Relevance 0
Ca(2+)/calmodulin-dependent protein kinase IV (CaM kinase IV) is a multifunctional enzyme that is abundantly present in the nuclei of neurons.
Gene_expression (present) of CaM kinase IV in neurons
5) Confidence 0.60 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.14
In both those studies, artificial knockdown or over-expression of Camk1g altered outgrowth of neuronal processes in a development context [80,81].
Gene_expression (expression) of Camk1g in neuronal
6) Confidence 0.55 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.07 Pain Relevance 0
Following seizure induction, CaMKII-alpha expression was downregulated and CaMKII-delta expression upregulated while CaMKII-beta and CaMKII-gamma expression was unaffected.
Gene_expression (expression) of CaMKII-gamma associated with convulsion
7) Confidence 0.00 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.34 Pain Relevance 0.13

General Comments

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