INT86542

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0.28
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Camk1g) plasma membrane (Camk1g) cytoplasm (Camk1g)
Anatomy Link Frequency
neurons 1
Camk1g (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 99.42 Very High Very High Very High
antagonist 2 98.24 Very High Very High Very High
central sensitization 1 98.22 Very High Very High Very High
Hippocampus 3 96.80 Very High Very High Very High
intrathecal 1 85.92 High High
Spinal cord 3 85.12 High High
qutenza 5 81.60 Quite High
bDMF 15 77.00 Quite High
nMDA receptor 2 76.72 Quite High
antidepressant 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 25 85.08 High High
Shock 6 70.56 Quite High
Osteogenic Sarcomas 6 36.96 Quite Low
Poisoning 12 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 9 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Repression 6 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Permethrin-mediated Gpd1 induction was statistically significant while Camk1g induction reflected the trends observed in the dose-response cohorts but did not reach statistical significance.
Positive_regulation (induction) of Camk1g
1) Confidence 0.64 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.06 Pain Relevance 0.09
For deltamethrin, both Camk1g and Gpd1 mRNA had maximally induced expression at 3 h followed by persistent elevations at 6 h (Figure 4).
Positive_regulation (induced) of Camk1g
2) Confidence 0.46 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.07 Pain Relevance 0.11
For permethrin, both Camk1g and Gpd1 had maximal induction at 6 h preceded by slight elevations at 3 h.
Positive_regulation (induction) of Camk1g
3) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.07 Pain Relevance 0.10
We report the properties of phosphorylation and activation of CaM kinase IV in comparison to CaM kinase II in cultured rat hippocampal neurons.
Positive_regulation (activation) of CaM kinase IV in neurons
4) Confidence 0.42 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.18
Glutamate-induced phosphorylation and activity of CaM kinase IV were blocked by N-methyl-D-asparate (NMDA) antagonists, and NMDA application instead of glutamate did increase CaM kinase IV phosphorylation.
Positive_regulation (activity) of CaM kinase IV associated with glutamate and antagonist
5) Confidence 0.42 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.37
These results suggest that increased phosphorylation of CREB protein may contribute to central sensitization following acute peripheral noxious stimuli, and the effect may be regulated through the activation of CaM kinase cascades.
Positive_regulation (activation) of CaM kinase associated with central sensitization
6) Confidence 0.28 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.47
The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB.
Positive_regulation (inactivated) of CaM kinase IV
7) Confidence 0.06 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.09 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox