INT86548

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Camk1g) plasma membrane (Camk1g) cytoplasm (Camk1g)
Camk1g (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 99.82 Very High Very High Very High
nMDA receptor 2 99.20 Very High Very High Very High
antagonist 2 98.76 Very High Very High Very High
tetrodotoxin 2 93.36 High High
Glutamate receptor 2 76.24 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glutamate-induced phosphorylation and activity of CaM kinase IV were blocked by N-methyl-D-asparate (NMDA) antagonists, and NMDA application instead of glutamate did increase CaM kinase IV phosphorylation.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of CaM kinase IV associated with glutamate and antagonist
1) Confidence 0.52 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.37
CaM kinase IV phosphorylation was also increased by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and was blocked by an inhibitor of NMDA receptor.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of CaM kinase IV associated with nmda receptor
2) Confidence 0.52 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.41

General Comments

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