INT86558

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 9
Disease Relevance 3.11
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cma1) extracellular region (Cma1) intracellular (Cma1)
Anatomy Link Frequency
cardiac myocytes 2
brain 1
Cma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 2 99.82 Very High Very High Very High
cINOD 5 99.00 Very High Very High Very High
metalloproteinase 11 98.56 Very High Very High Very High
interstitial cystitis 6 94.32 High High
fibrosis 8 90.48 High High
Inflammatory response 4 84.72 Quite High
imagery 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 20 99.20 Very High Very High Very High
Hypertension 375 97.56 Very High Very High Very High
Anaphylaxis 2 95.84 Very High Very High Very High
Myocardial Infarction 4 94.80 High High
Interstitial Cystitis 6 94.32 High High
Hyperplasia 2 91.72 High High
Pulmonary Fibrosis 2 91.28 High High
INFLAMMATION 5 84.72 Quite High
Fibrosis 6 79.92 Quite High
Diabetes Mellitus 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral administration of NK3201 into normal rats resulted in rapid spread over every tissue except the brain, and sufficient activity to inhibit tissue chymase was detected even after 24 h.
Negative_regulation (inhibit) of chymase in brain
1) Confidence 0.45 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12499575 Disease Relevance 0.86 Pain Relevance 0.33
In this review, by showing the efficacy of NK3201 in some hamster models, chymase functions in vivo are summarized, and the potency of this chymase inhibitor is introduced.
Negative_regulation (inhibitor) of chymase associated with potency
2) Confidence 0.38 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12499575 Disease Relevance 0.49 Pain Relevance 0.14
To clarify the involvement of chymase-dependent MMP-9 activation on NSAID-induced small intestinal damage, the effect of a chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl] thiazole-4-carboxylic acid (TY-51469), on indomethacin-induced small intestinal damage in rats was evaluated.
Negative_regulation (inhibitor) of chymase associated with cinod and metalloproteinase
3) Confidence 0.35 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19996300 Disease Relevance 0.08 Pain Relevance 0.78
Medium was collected after exposing the WKY and SHR cells for 60 min at 37°C under two different enzyme inhibitors conditions (+All RAS inhibitors versus minus ACE/NEP/ACE2/chymase inhibitor only) and were analyzed by HPLC as described above.
Negative_regulation (inhibitor) of chymase associated with hypertension
4) Confidence 0.27 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.10 Pain Relevance 0
Table 1 summarizes the effects of selective inhibition of ACE, NEP, ACE2, and chymase on 125I-Ang-(1–12) metabolism in the culture medium from both WKY and SHR.
Negative_regulation (inhibition) of chymase associated with hypertension
5) Confidence 0.24 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.65 Pain Relevance 0
Ang-(1–12) metabolism by cardiac myocytes was significantly blocked in the presence of specific enzyme inhibitors for ACE, neprilysin, ACE2, and chymase.
Negative_regulation (inhibitors) of chymase in cardiac myocytes
6) Confidence 0.24 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.40 Pain Relevance 0
The contribution of ACE, NEP, ACE2 or chymase to the hydrolysis of 125I-Ang-(1–12) substrate were analyzed by measuring the amount of Ang products formation in the cultured medium after exposing the cells in the presence of all RAS inhibitors cocktail and in the absence of specific enzyme inhibitors for ACE, NEP, ACE2 or chymase only (as described above).
Negative_regulation (inhibitors) of chymase
7) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.09 Pain Relevance 0
The degradation of 125I-Ang-(1–12) (1 nmol/L) in the cultured medium of these cardiac myocytes was evaluated in the presence and absence of inhibitors for angiotensin converting enzymes 1 and 2, neprilysin and chymase.
Negative_regulation (inhibitors) of chymase in cardiac myocytes
8) Confidence 0.17 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3018413 Disease Relevance 0.10 Pain Relevance 0
It has been suggested that the proteinase content defines two MC types: MC(TC), containing chymase and tryptase, and MC(T), which contains tryptase but lacks chymase.
Negative_regulation (lacks) of chymase
9) Confidence 0.03 Published 2000 Journal J. Urol. Section Abstract Doc Link 10688040 Disease Relevance 0.34 Pain Relevance 0.34

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