INT86569

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Context Info
Confidence 0.15
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (AP2S1) cytosol (AP2S1) transport (AP2S1)
vesicle-mediated transport (AP2S1) plasma membrane (AP2S1)
Anatomy Link Frequency
myoblasts 1
SK-N-SH 1
AP2S1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 49.68 Quite Low
fortral 1 36.56 Quite Low
antagonist 1 25.00 Low Low
Antihistamine 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 99.86 Very High Very High Very High
Mucopolysaccharidosis Ii 7 89.44 High High
Disease 43 81.76 Quite High
Gauchers Disease 1 63.40 Quite High
Lysosome Storage Disease 8 62.04 Quite High
Lysosomal Storage Diseases 2 19.28 Low Low
Death 8 5.00 Very Low Very Low Very Low
Deafness 7 5.00 Very Low Very Low Very Low
Airway Obstruction 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human SK-N-SH neuroblastoma cells expressed sigma-1 and sigma-2 receptors with similar pharmacological profiles to those of rodent-derived tissues, although sigma-2 receptors exhibited some affinity differences that might suggest heterogeneity or species differences.
Gene_expression (expressed) of sigma-2 in SK-N-SH associated with neuroblastoma
1) Confidence 0.15 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10688603 Disease Relevance 0.17 Pain Relevance 0
Use of nanoparticles containing engineered myoblasts expressing I2S has been reported.
Gene_expression (expressing) of I2S in myoblasts
2) Confidence 0.02 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2234442 Disease Relevance 0.37 Pain Relevance 0

General Comments

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