INT86600

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 37
Total Number 48
Disease Relevance 14.88
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (KCNH2) plasma membrane (KCNH2) transmembrane transport (KCNH2)
cytoplasm (KCNH2)
Anatomy Link Frequency
oocytes 7
tail 2
Section 2 2
surface epithelium 1
plasma 1
KCNH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 105 100.00 Very High Very High Very High
Nav1.2 1 100.00 Very High Very High Very High
qutenza 10 99.76 Very High Very High Very High
methadone 38 99.32 Very High Very High Very High
fluoxetine 15 98.82 Very High Very High Very High
Action potential 170 98.40 Very High Very High Very High
Lamotrigine 6 92.48 High High
antiepileptic Drug 5 91.76 High High
tricyclic antidepressant 86 89.32 High High
addiction 289 87.20 High High
Disease Link Frequency Relevance Heat
Ovarian Cancer 372 99.92 Very High Very High Very High
Cancer 348 99.36 Very High Very High Very High
Malignant Neoplastic Disease 45 98.96 Very High Very High Very High
Syndrome 558 98.52 Very High Very High Very High
Disease 255 98.36 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 42 98.34 Very High Very High Very High
Endometrial Cancer 12 97.56 Very High Very High Very High
Colon Cancer 24 96.44 Very High Very High Very High
Leukemia 12 95.36 Very High Very High Very High
Neuroblastoma 24 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the electrophysiological basis for the arrhythmogenic potential of fluoxetine, we investigated the effects of this drug on cloned human ether-a-go-go-related gene (HERG) potassium channels heterologously expressed in Xenopus oocytes using the two-microelectrode voltage-clamp technique.
Gene_expression (expressed) of HERG in oocytes associated with potassium channel, arrhythmogenic right ventricular dysplasia and fluoxetine
1) Confidence 0.78 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805215 Disease Relevance 0.28 Pain Relevance 0.90
HEK 293 (human embryonic kidney) cells stably expressing hERG (human ether-a-go-go-related gene) were treated with fexinidazole, fexinidazole sulfoxide, or fexinidazole sulfone at 1, 5 or 30 µM, and the hERG peak tail current was measured.


Gene_expression (expressing) of hERG in tail
2) Confidence 0.75 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006138 Disease Relevance 0 Pain Relevance 0
METHODS: The effects of the isomers on IKr were evaluated by using an oocytes system with heterogeneously expressed human ether-a-go-go-related gene (HERG) using the 2 electrode voltage clamp technique. r- and s-methadone were obtained by employing chiral high-performance liquid chromatography, separating methadone into 2 isolates, with optical rotations of -141 and +143 degrees.
Gene_expression (expressed) of HERG in oocytes
3) Confidence 0.68 Published 2009 Journal Cardiology Section Body Doc Link 18984955 Disease Relevance 0 Pain Relevance 0
METHODS: The effects of the isomers on IKr were evaluated by using an oocytes system with heterogeneously expressed human ether-a-go-go-related gene (HERG) using the 2 electrode voltage clamp technique. r- and s-methadone were obtained by employing chiral high-performance liquid chromatography, separating methadone into 2 isolates, with optical rotations of -141 and +143 degrees.
Gene_expression (expressed) of ether-a-go-go-related in oocytes
4) Confidence 0.68 Published 2009 Journal Cardiology Section Body Doc Link 18984955 Disease Relevance 0 Pain Relevance 0
To determine the electrophysiological basis for the arrhythmogenic potential of fluoxetine, we investigated the effects of this drug on cloned human ether-a-go-go-related gene (HERG) potassium channels heterologously expressed in Xenopus oocytes using the two-microelectrode voltage-clamp technique.
Gene_expression (expressed) of ether-a-go-go-related gene in oocytes associated with potassium channel, arrhythmogenic right ventricular dysplasia and fluoxetine
5) Confidence 0.68 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805215 Disease Relevance 0.28 Pain Relevance 0.91
Although we did not co-express HERG with MiRP1, a putative ?
Gene_expression (-) of HERG
6) Confidence 0.67 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0.16
subunit suggested to be necessary to recapitulate native IKr [55], it has recently been suggested that MiRP1 is unlikely to interact with HERG outside of the cardiac conduction system [51] and, additionally, the pharmacological sensitivity of HERG channels expressed in mammalian cells without MiRP1 co-expression has been found to be similar to that of native IKr [56].
Neg (without) Gene_expression (expressed) of HERG in cardiac conduction system
7) Confidence 0.67 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0.19
Staining of normal ovary (n = 6) demonstrated low level expression of both Eag and HERG on the surface epithelium compared to ovarian cancer (shown by arrow in Figure 3C).


Gene_expression (expression) of HERG in surface epithelium associated with ovarian cancer
8) Confidence 0.65 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.78 Pain Relevance 0
This is the first study to examine the expression of Eag and HERG channels in ovarian cancer biopsies, with subsequent relation to prognostic factors.
Spec (examine) Gene_expression (expression) of HERG associated with ovarian cancer
9) Confidence 0.65 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.20 Pain Relevance 0.03
Four main K+ channel subtypes (Kv1.3, K2p9.1, Eag and HERG) are found to be overexpressed in a number of tumour types [4].
Gene_expression (overexpressed) of HERG associated with cancer
10) Confidence 0.65 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.72 Pain Relevance 0
HERG expression has also been demonstrated in clinical cancers that include endometrial carcinoma [17], colorectal cancer [18] and acute myeloid leukaemia [19].
Gene_expression (expression) of HERG associated with leukemia, cancer, colon cancer and endometrial cancer
11) Confidence 0.65 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.34 Pain Relevance 0.04
This makes it difficult to extrapolate with accuracy from known plasma concentrations to likely levels of IHERG/IKr blockade by doxepin in vivo.
Gene_expression (blockade) of HERG in plasma
12) Confidence 0.65 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0.05 Pain Relevance 0.13
M (shown in Fig. 1 to produce extensive inhibition of WT IHERG with a standard [K+]e).
Gene_expression (produce) of HERG
13) Confidence 0.65 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0
-blocker therapy (very good in LQT1, reasonable in LQT2 and apparently poor in LQT3) and also to conditions that could favor the occurrence of life-threatening arrhythmias are different.
Gene_expression (reasonable) of LQT2
14) Confidence 0.60 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.21 Pain Relevance 0
The KCNH2 gene and the KCNE2 gene encode respectively the alpha (HERG – Human Ether-a-go-go Related Gene) and the ?
Gene_expression (gene) of KCNH2
15) Confidence 0.60 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.90 Pain Relevance 0.12
The results demonstrate (a) the high quality of whole-cell recordings obtainable from cell lines expressing human Nav1.2 or hERG ion channels, (b) the advantages of the methodology for increasing throughput, and (c) examples of how these assays support ion channel drug discovery.
Gene_expression (expressing) of hERG associated with nav1.2
16) Confidence 0.54 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19551364 Disease Relevance 0 Pain Relevance 0.10
RESULTS: At concentrations of 0.01, 0.03, 0.1, 1 and 3 mM, r/s-methadone produced a dose-dependent inhibition of HERG by 17 +/- 5, 23 +/- 4, 40 +/- 4, 57 +/- 3, 69 +/- 3 and 80 +/- 1%, respectively.
Gene_expression (produced) of HERG
17) Confidence 0.53 Published 2009 Journal Cardiology Section Body Doc Link 18984955 Disease Relevance 0 Pain Relevance 0
Electrophysiologic and pharmacologic properties of wild-type and mutant HERG channels were established using two-electrode voltage-clamp recordings of Xenopus laevis oocytes expressing HERG channels.
Gene_expression (expressing) of HERG in oocytes
18) Confidence 0.53 Published 2007 Journal Anesthesiology Section Body Doc Link 17325511 Disease Relevance 0 Pain Relevance 0
METHODS: The authors examined the inhibition of wild-type and mutant HERG channels, transiently expressed in Chinese hamster ovary cells by bupivacaine, ropivacaine, and mepivacaine.
Gene_expression (expressed) of HERG in ovary
19) Confidence 0.53 Published 2005 Journal Anesthesiology Section Body Doc Link 15983462 Disease Relevance 0 Pain Relevance 0
In our opinion, the highest risk for LQT2 women is at least in part related to sleep disruption; accordingly, we recommend not only to continue with full dose of ?
Gene_expression (women) of LQT2
20) Confidence 0.53 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.47 Pain Relevance 0

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