INT86601

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.56
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (KCNH2) plasma membrane (KCNH2) transmembrane transport (KCNH2)
cytoplasm (KCNH2)
Anatomy Link Frequency
myocytes 1
tail 1
KCNH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 39 99.92 Very High Very High Very High
qutenza 1 97.24 Very High Very High Very High
iatrogenic 2 94.48 High High
action potential duration 13 63.68 Quite High
Migraine 1 61.64 Quite High
tricyclic antidepressant 7 50.00 Quite Low
potassium channel 4 50.00 Quite Low
Calcium channel 3 42.72 Quite Low
anesthesia 6 38.12 Quite Low
Inflammation 13 21.84 Low Low
Disease Link Frequency Relevance Heat
Sudden Death 8 92.48 High High
Convulsion 1 91.80 High High
Syncope 5 91.44 High High
Heart Disease 3 90.44 High High
Syndrome 41 89.64 High High
Systemic Inflammatory Response Syndrome 22 87.88 High High
Pneumonia 8 85.04 High High
Sudden Infant Death Syndrome 2 73.80 Quite High
Epilepsy 1 62.20 Quite High
Headache 1 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
4.2 fold increase in IC50 over that for WT IHERG.
Positive_regulation (increase) of HERG
1) Confidence 0.49 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0
At concentrations near or above the IC50, flunarizine causes a negative shift in the voltage dependence of hERG current activation and accelerates tail current deactivation.
Positive_regulation (activation) of hERG in tail associated with addiction
2) Confidence 0.33 Published 2006 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16495758 Disease Relevance 0.19 Pain Relevance 0.20
Auditory stimuli and arousal are a relatively specific trigger for LQT2 patients while swimming is a predisposing setting for cardiac events in LQT1 patients [3].
Positive_regulation (trigger) of LQT2
3) Confidence 0.29 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.66 Pain Relevance 0
POD 1 upregulation of PDGFA, ERG1, and HMGB1 mRNA correlated significantly with worse prognosis.
Positive_regulation (upregulation) of ERG1
4) Confidence 0.23 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.26 Pain Relevance 0.11
RESULTS: Our experiments show that low drug concentrations (5 mumol/l) facilitate HERG currents, while higher drug concentrations block HERG currents (IC50-values of approx. 40 mumol/l) and dramatically shift the reversal potential to a more positive value because of a 30-fold increased Na(+)-permeability.
Positive_regulation (facilitate) of HERG
5) Confidence 0.21 Published 1999 Journal Cardiovasc. Res. Section Body Doc Link 10690289 Disease Relevance 0 Pain Relevance 0
In guinea pig ventricular myocytes, the shift of the activation of HERG K+ channel induced by phorbol ester involves a PKA-dependent pathway [27].
Positive_regulation (activation) of HERG in myocytes
6) Confidence 0.12 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC117783 Disease Relevance 0.46 Pain Relevance 0.11
FMP has also been used to measure the activation of K(ATP) and hERG.
Positive_regulation (activation) of hERG
7) Confidence 0.00 Published 2002 Journal J Biomol Screen Section Abstract Doc Link 11897058 Disease Relevance 0 Pain Relevance 0.10

General Comments

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