INT86605

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ntsr1) plasma membrane (Ntsr1) signal transducer activity (Ntsr1)
Anatomy Link Frequency
tail 1
Ntsr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 100.00 Very High Very High Very High
Chronic pancreatitis 9 97.12 Very High Very High Very High
withdrawal 1 95.52 Very High Very High Very High
antinociception 1 94.36 High High
Pain 2 81.44 Quite High
Antinociceptive 1 75.00 Quite High
Neuropeptide 1 74.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 5 98.76 Very High Very High Very High
Pancreatic Cancer 9 98.48 Very High Very High Very High
Pancreatitis 10 97.12 Very High Very High Very High
Hypothermia 1 93.68 High High
Pain 1 81.44 Quite High
Schizophrenia 1 76.60 Quite High
Cancer 6 66.32 Quite High
Nociception 1 63.68 Quite High
Carcinoma 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In WT mice, both NTR1 agonists decreased core body temperature (active doses in mg/kg, i.p., for NT-2 and NT69L, respectively: 1 and 3), increased tail withdrawal latencies (1 and 3), produced decreased spontaneous climbing (0.1, 0.3, 1 and 1, 3, 10) and reversed apomorphine-induced climbing (0.3, 1 and 1, 3).
Localization (decreased) of NTR1 in tail associated with agonist and withdrawal
1) Confidence 0.75 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 19223157 Disease Relevance 0.73 Pain Relevance 0.49
Expression and localization of NTR-1 mRNA was investigated by Northern blot analysis and in situ hybridization.
Localization (localization) of NTR-1 mRNA
2) Confidence 0.63 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.08 Pain Relevance 0.41

General Comments

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