INT86607

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ntsr1) plasma membrane (Ntsr1) signal transducer activity (Ntsr1)
Anatomy Link Frequency
body 1
Ntsr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 9 99.98 Very High Very High Very High
Analgesic 6 99.98 Very High Very High Very High
Pain 1 99.82 Very High Very High Very High
analgesia 3 96.88 Very High Very High Very High
Morphine 4 96.68 Very High Very High Very High
narcan 1 77.36 Quite High
antagonist 3 77.00 Quite High
opioid receptor 3 76.56 Quite High
Intracerebroventricular 2 68.96 Quite High
agonist 1 65.24 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 10 99.98 Very High Very High Very High
Pancreatic Cancer 9 98.84 Very High Very High Very High
Carcinoma 1 88.76 High High
Congenital Anomalies 1 83.00 Quite High
Cancer 6 81.48 Quite High
Nociception 1 75.00 Quite High
Hypothermia 1 65.92 Quite High
Body Weight 1 62.12 Quite High
Pain 1 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia.
Negative_regulation (inactivation) of neurotensin type 1 receptor in body associated with analgesic and analgesia
1) Confidence 0.43 Published 2002 Journal Brain Res. Section Title Doc Link 12384239 Disease Relevance 0.21 Pain Relevance 0.49
However, its relatively high levels in CP excludes NTR-1 mRNA as a specific parameter for pancreatic cancer and for the differentiation of pancreatic cancer from CP.
Negative_regulation (excludes) of NTR-1 mRNA associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.38 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.41 Pain Relevance 0.41
In mice made tolerant to the analgesic effect of NT1 (0.3 mg/kg, s.c.) by previous NT1 injections (3 mg/kg, s.c., twice a day, 4 days) morphine maintained its analgesic effects both on licking and jumping latencies.
Negative_regulation (effect) of NT1 associated with analgesic and morphine
3) Confidence 0.08 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 17074405 Disease Relevance 0.14 Pain Relevance 1.08

General Comments

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