INT8661

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Context Info
Confidence 0.66
First Reported 1992
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 10.90
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
chondrocytes 2
epithelium 2
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 99.36 Very High Very High Very High
ischemia 42 98.56 Very High Very High Very High
Osteoarthritis 70 97.84 Very High Very High Very High
cytokine 25 95.24 Very High Very High Very High
aspirin 3 92.80 High High
fibrosis 3 88.96 High High
metalloproteinase 22 88.16 High High
Inflammation 31 87.92 High High
agonist 1 85.92 High High
Fibrositis 2 82.24 Quite High
Disease Link Frequency Relevance Heat
Stress 90 99.88 Very High Very High Very High
Injury 63 99.66 Very High Very High Very High
Glaucoma 262 99.08 Very High Very High Very High
Cv Unclassified Under Development 56 98.56 Very High Very High Very High
Reprotox - General 1 32 97.96 Very High Very High Very High
Osteoarthritis 72 97.84 Very High Very High Very High
Freckles 2 97.52 Very High Very High Very High
INFLAMMATION 39 94.36 High High
Pulmonary Hypertension 162 94.32 High High
Cancer 132 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although animal models have suggested that increased levels of ET-1 by itself can lead to glaucoma via ischemia (Cioffi et al 2004), these same results have not been demonstrated in human population studies.
Positive_regulation (increased) of Positive_regulation (levels) of ET-1 associated with ischemia and glaucoma
1) Confidence 0.66 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.39 Pain Relevance 0.21
Oxidative stress also leads to an unspecific increase in endothelin-1 (ET-1).
Positive_regulation (leads) of Positive_regulation (increase) of endothelin-1 associated with stress
2) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267728 Disease Relevance 1.38 Pain Relevance 0.08
Our results suggest that the activation of PKA is also required for the ET-1-induced upregulation of iNOS and for subsequent production of NO by human OA chondrocytes.
Positive_regulation (required) of Positive_regulation (upregulation) of ET-1-induced in chondrocytes associated with osteoarthritis
3) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.27 Pain Relevance 0.14
However, PKA activation seems to be less required for the ET-1-induced upregulation of MMP-13 and not at all necessary for the upregulation of MMP-1 since the inhibition of PKA with KT5720 does not affect the ET-1-induced overproduction of this enzyme.
Neg (not) Positive_regulation (necessary) of Positive_regulation (upregulation) of ET-1-induced
4) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.26 Pain Relevance 0.14
Although animal models have suggested that increased levels of ET-1 by itself can lead to glaucoma via ischemia (Cioffi et al 2004), these same results have not been demonstrated in human population studies.
Positive_regulation (levels) of Positive_regulation (increased) of ET-1 associated with ischemia and glaucoma
5) Confidence 0.44 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.39 Pain Relevance 0.21
There is evidence that NSAID-induced injury may cause endothelin activation.
Spec (may) Positive_regulation (cause) of Spec (may) Positive_regulation (activation) of endothelin associated with injury and cinod
6) Confidence 0.37 Published 1999 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 10233186 Disease Relevance 0.37 Pain Relevance 0.41
Oxidative stress also leads to an unspecific increase in endothelin-1 (ET-1).
Positive_regulation (leads) of Positive_regulation (increase) of ET-1 associated with stress
7) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267728 Disease Relevance 1.39 Pain Relevance 0.08
In epithelium-denuded strips, preincubation with phosphoramidon did not further increase the maximal contractions induced by/or the potencies of ET-1, ET-2 or ET-3.
Neg (not) Positive_regulation (increase) of Neg (not) Positive_regulation (induced) of ET-1 in epithelium
8) Confidence 0.34 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1377128 Disease Relevance 0 Pain Relevance 0.22
In prostate cancer, key components of the ET-1 clearance pathway, ETB and neutral endopeptidease (NEP), are diminished, resulting in an increase in local ET-1 concentrations.
Positive_regulation (resulting) of Positive_regulation (increase) of ET-1 associated with reprotox - general 1
9) Confidence 0.27 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.29 Pain Relevance 0.03
Therefore, ET-1-induced HIF-1 accumulation activates all the signals necessary for a complete HIF-1 response [19].
Positive_regulation (activates) of Positive_regulation (accumulation) of ET-1-induced
10) Confidence 0.27 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.98 Pain Relevance 0.08
This results in abnormally high concentrations in pulmonary arteries (Giaid et al 1993) and an increase in circulating ET-1 (Humbert, Morrell et al 2004; Rubin 2004).
Positive_regulation (increase) of Positive_regulation (increase) of ET-1
11) Confidence 0.05 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350123 Disease Relevance 1.72 Pain Relevance 0.13
The clinical impact is not yet fully understood, but possible underlying mechanisms include scavenging of nitric oxide, augmented release of endothelin, and stimulation of endothelin receptors and adrenoreceptors [117-120].
Positive_regulation (augmented) of Positive_regulation (stimulation) of endothelin
12) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 0.46 Pain Relevance 0.04

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