INT86625

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Context Info
Confidence 0.24
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 8
Total Number 8
Disease Relevance 2.52
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pla2g1b) extracellular space (Pla2g1b) extracellular region (Pla2g1b)
response to stress (Pla2g1b)
Pla2g1b (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 11 100.00 Very High Very High Very High
Inflammation 70 99.40 Very High Very High Very High
aspirin 10 98.80 Very High Very High Very High
diclofenac 5 97.48 Very High Very High Very High
rheumatoid arthritis 65 95.36 Very High Very High Very High
antagonist 4 88.32 High High
adenocard 5 87.44 High High
qutenza 3 80.64 Quite High
analgesia 3 75.00 Quite High
Arthritis 17 68.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 90 100.00 Very High Very High Very High
Rheumatoid Arthritis 65 95.36 Very High Very High Very High
Pressure And Volume Under Development 33 82.72 Quite High
Apoptosis 2 75.72 Quite High
Disease 26 75.00 Quite High
Death 4 72.44 Quite High
Arthritis 20 68.68 Quite High
Rheumatic Diseases 2 68.12 Quite High
Shock 2 53.36 Quite High
Toxicity 4 50.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A2: crystal structure of the complex formed between phospholipase A2 and aspirin at 1.9 angstroms resolution.
phospholipase A2 Binding (binding) of associated with aspirin and inflammation
1) Confidence 0.24 Published 2005 Journal J Drug Target Section Title Doc Link 15823962 Disease Relevance 0.19 Pain Relevance 0.58
It is cleaved by phospholipase A2 (PLA)(2) to a greater extent than similar compounds with linkers of 2, 3, and 4 carbons.
phospholipase A2 Binding (cleaved) of
2) Confidence 0.16 Published 2007 Journal CNS Drug Rev Section Abstract Doc Link 17627676 Disease Relevance 0.20 Pain Relevance 0.07
Cellular incubation conditions were carefully developed to possibly mimic the cellular metabolism of dietary 5,11,14 20:3, and test the anti-inflammatory potential of 5,11, 14 20:3 in vitro. 5,11,14 was incubated for a long period of time to allow it to be taken up by cellular PL and accumulate in PL (as a result of a supposed poor affinity for phospholipase A2); and to eventually, displace 20:4n-6 from PL pools resulting in less production of 20:4n-6 derived anti-inflammatory products, following challenge.
phospholipase A2 Binding (affinity) of associated with inflammation
3) Confidence 0.09 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.47 Pain Relevance 0.13
Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution.
phospholipase A2 Binding (binding) of associated with inflammation, cinod and diclofenac
4) Confidence 0.05 Published 2006 Journal Acta Crystallogr. D Biol. Crystallogr. Section Title Doc Link 16552142 Disease Relevance 0.27 Pain Relevance 0.55
This is mediated through CD74, the subsequent engagement of p38 MAPK, ERK, Src kinase, phospholipase A2 and PI3K pathways [104-108], and the binding of NF-?
phospholipase A2 Binding (engagement) of
5) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.61 Pain Relevance 0.24
Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution.
phospholipase A2 Binding (complex) of associated with inflammation and cinod
6) Confidence 0.04 Published 2005 Journal Acta Crystallogr. D Biol. Crystallogr. Section Title Doc Link 16301791 Disease Relevance 0.37 Pain Relevance 0.23
Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution.
phospholipase A2 Binding (complex) of associated with inflammation and cinod
7) Confidence 0.04 Published 2005 Journal Acta Crystallogr. D Biol. Crystallogr. Section Title Doc Link 16301791 Disease Relevance 0.37 Pain Relevance 0.23
In addition, their ligand-binding inhibitory activity depended on their phospholipase A2 activity.
phospholipase A2 Binding (ligand-binding) of
8) Confidence 0.03 Published 2000 Journal Eur. J. Biochem. Section Abstract Doc Link 10691971 Disease Relevance 0.05 Pain Relevance 0.39

General Comments

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