INT8663

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.65
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN2) extracellular region (EDN2)
Anatomy Link Frequency
kidney 2
blood 1
epithelium 1
EDN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thoracotomy 20 93.52 High High
agonist 1 84.56 Quite High
antagonist 2 83.20 Quite High
Potency 3 75.08 Quite High
Enkephalin 1 75.00 Quite High
tetrodotoxin 1 72.36 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Decubitus Ulcers 10 96.68 Very High Very High Very High
Pulmonary Disease 5 92.42 High High
Erythema 5 78.28 Quite High
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Burns 5 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In epithelium-denuded strips, preincubation with phosphoramidon did not further increase the maximal contractions induced by/or the potencies of ET-1, ET-2 or ET-3.
Neg (not) Positive_regulation (induced) of ET-2 in epithelium
1) Confidence 0.38 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1377128 Disease Relevance 0 Pain Relevance 0.22
One class (ET(A) receptor) had a high affinity for ET-1 and ET-2 but a low affinity for ET-3, and the other (ET(B) receptor) a high affinity for ET-1, ET-2 and ET-3.
Positive_regulation (affinity) of ET-2
2) Confidence 0.33 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11231044 Disease Relevance 0 Pain Relevance 0.15
There was a significant increase in the ET-CO2 to PaCO2 gradient during OLV (5.8 ± 2.3 mmHg), while no change was noted in the TC-CO2 to PaCO2 difference (2.7 ± 1.4 mmHg).
Positive_regulation (increase) of ET-CO2
3) Confidence 0.33 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0 Pain Relevance 0.10
Alternatively, areas of low ventilation-perfusion ratios (shunt) result in ineffective gas exchange and the addition of blood with a high partial pressure of CO2 to the arterial circulation contributing to the increased ET-CO2 to PaCO2 gradient.[17–18]
Positive_regulation (increased) of ET-CO2 in blood
4) Confidence 0.33 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0 Pain Relevance 0
Several factors may be responsible for discrepancies between ET-CO2 and PaCO2, including technical issues with the monitor; and patient-related factors, including ventilation-perfusion mismatch, dead space and true shunt.[1213] Whitesell et al demonstrated that patients with underlying lung disease had a significantly greater ET-CO2 to PaCO2 gradient when compared with patients with normal baseline pulmonary function (3.3 ± 0.6 mmHg versus 0.8 ± 0.3 mmHg).[13] Patient positioning has also been shown to have an impact on the accuracy of ET-CO2 monitoring.[23] With patients undergoing renal or upper ureteral surgery in the supine position, Pansard et al reported that the ET-CO2 to PaCO2 difference was 4.8 ± 3.9 mmHg 10 min after induction and increased to 7.9 ± 3.5 mmHg (P<0.01) 5 min after placement of the patients into the lateral decubitus ‘kidney rest’ position.
Positive_regulation (discrepancies) of ET-CO2 in kidney associated with pulmonary disease and decubitus ulcers
5) Confidence 0.24 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0.23 Pain Relevance 0
Although no significant change was noted in the TC-CO2 to PaCO2 gradient during OLV (3.5 ± 1.7 mmHg), the ET-CO2 to PaCO2 difference increased to 9.6 ± 3.6 mmHg.
Positive_regulation (increased) of ET-CO2
6) Confidence 0.22 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0.15 Pain Relevance 0
Several factors may be responsible for discrepancies between ET-CO2 and PaCO2, including technical issues with the monitor; and patient-related factors, including ventilation-perfusion mismatch, dead space and true shunt.[1213] Whitesell et al demonstrated that patients with underlying lung disease had a significantly greater ET-CO2 to PaCO2 gradient when compared with patients with normal baseline pulmonary function (3.3 ± 0.6 mmHg versus 0.8 ± 0.3 mmHg).[13] Patient positioning has also been shown to have an impact on the accuracy of ET-CO2 monitoring.[23] With patients undergoing renal or upper ureteral surgery in the supine position, Pansard et al reported that the ET-CO2 to PaCO2 difference was 4.8 ± 3.9 mmHg 10 min after induction and increased to 7.9 ± 3.5 mmHg (P<0.01) 5 min after placement of the patients into the lateral decubitus ‘kidney rest’ position.
Positive_regulation (increased) of ET-CO2 in kidney associated with pulmonary disease and decubitus ulcers
7) Confidence 0.22 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0.27 Pain Relevance 0.03

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