INT86634

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (POMC, TYR) small molecule metabolic process (POMC) cell-cell signaling (POMC)
pigmentation (TYR) cell proliferation (TYR) extracellular space (POMC)
Anatomy Link Frequency
melanocyte 1
POMC (Homo sapiens)
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 5 97.56 Very High Very High Very High
opiate 1 69.60 Quite High
melanocortin 1 receptor 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we demonstrate reactivation of the 7BH(4)/tyrosinase inhibitor complex by beta-MSH, whereas alpha-MSH failed to do so.
beta-MSH Positive_regulation (reactivation) of tyrosinase
1) Confidence 0.42 Published 2005 Journal J. Endocrinol. Section Abstract Doc Link 16293777 Disease Relevance 0 Pain Relevance 0.15
Recently, it has been shown that alpha-melanocyte stimulating hormone can directly activate tyrosinase by removing the allosteric regulator 6(R)-L-erythro 5,6,7,8 tetrahydrobiopterin resulting in a stable alpha-melanocyte stimulating hormone/6(R)-L-erythro 5,6,7,8 tetrahydrobiopterin complex.
alpha-melanocyte stimulating hormone Positive_regulation (activate) of tyrosinase in melanocyte associated with tetrahydrobiopterin
2) Confidence 0.40 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692100 Disease Relevance 0 Pain Relevance 0.10

General Comments

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