INT86637

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2003
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
cell proliferation (KRT16) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
Anatomy Link Frequency
skin 2
POMC (Homo sapiens)
KRT16 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 14 99.08 Very High Very High Very High
Neuropeptide 1 99.00 Very High Very High Very High
agonist 1 97.16 Very High Very High Very High
psoriasis 4 84.80 Quite High
Opioid 4 63.52 Quite High
Pain 3 54.12 Quite High
Inflammatory response 1 40.96 Quite Low
Disease Link Frequency Relevance Heat
Injury 8 99.82 Very High Very High Very High
Wound Healing 3 96.12 Very High Very High Very High
Psoriasis 6 91.32 High High
Skin Diseases 1 75.44 Quite High
Pain 2 54.12 Quite High
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, we show that beta-endorphin regulates cytokeratin 16 expression in the epidermis of skin organ cultures exposed to 41-125 nM beta-endorphin for 48 h, leading to elevated cytokeratin 16 production.
beta-endorphin Regulation (regulates) of Gene_expression (expression) of cytokeratin 16 in skin
1) Confidence 0.47 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.40 Pain Relevance 0.80
Different expression of mu-opiate receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression.
beta-endorphin Regulation (effect) of Gene_expression (expression) of cytokeratin 16 associated with injury and opiate
2) Confidence 0.34 Published 2003 Journal J. Invest. Dermatol. Section Title Doc Link 12535211 Disease Relevance 0.82 Pain Relevance 0.81

General Comments

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