INT86639

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 12.44
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KRT16) cytoskeleton organization (KRT16)
Anatomy Link Frequency
epidermis 13
choroid plexus 1
keratinocytes 1
sweat glands 1
KRT16 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 223 100.00 Very High Very High Very High
opiate 66 99.50 Very High Very High Very High
Neuropeptide 7 99.00 Very High Very High Very High
cytokine 76 97.76 Very High Very High Very High
agonist 3 97.16 Very High Very High Very High
Opioid 17 96.20 Very High Very High Very High
medulla 51 92.16 High High
Inflammation 106 91.64 High High
Central nervous system 32 90.80 High High
Fibrositis 48 72.16 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 311 100.00 Very High Very High Very High
Skin Cancer 203 99.84 Very High Very High Very High
Cancer 599 99.82 Very High Very High Very High
Injury 110 99.78 Very High Very High Very High
Chronic Fatigue Syndrome 368 99.28 Very High Very High Very High
Wound Healing 37 97.80 Very High Very High Very High
Metaplasia 28 97.28 Very High Very High Very High
Syndrome 78 96.20 Very High Very High Very High
Amyloidosis 18 95.56 Very High Very High Very High
Oral Leukoplakia 7 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, we show that beta-endorphin regulates cytokeratin 16 expression in the epidermis of skin organ cultures exposed to 41-125 nM beta-endorphin for 48 h, leading to elevated cytokeratin 16 production.
Gene_expression (production) of cytokeratin 16 in skin
1) Confidence 0.68 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.38 Pain Relevance 0.78
beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opiate receptor expression in human epidermis.
Gene_expression (expression) of cytokeratin 16 in epidermis associated with opiate
2) Confidence 0.68 Published 2000 Journal J. Invest. Dermatol. Section Title Doc Link 10692113 Disease Relevance 0.32 Pain Relevance 0.67
Secondly, we show that beta-endorphin regulates cytokeratin 16 expression in the epidermis of skin organ cultures exposed to 41-125 nM beta-endorphin for 48 h, leading to elevated cytokeratin 16 production.
Gene_expression (expression) of cytokeratin 16 in skin
3) Confidence 0.68 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.40 Pain Relevance 0.79
As expected, the expression of cytokeratin 16 was detected primarily in the suprabasal layer.
Gene_expression (expression) of cytokeratin 16
4) Confidence 0.68 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.38 Pain Relevance 0.78
In this study, we addressed the question whether there is a link between mu-opiate receptor regulation and cytokeratin 16 expression in normal and psoriatic skin.
Gene_expression (expression) of cytokeratin 16 in skin associated with psoriasis and opiate
5) Confidence 0.68 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.42 Pain Relevance 0.74
The same pattern was observed in psoriatic lesional skin, i.e., mu-opiate receptor expression was significantly downregulated and cytokeratin 16 expression upregulated.
Gene_expression (expression) of cytokeratin 16 in skin associated with psoriasis and opiate
6) Confidence 0.68 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.35 Pain Relevance 0.71
We have previously observed that beta-endorphin, the endogenous ligand for the mu-opiate receptor, stimulates the expression of cytokeratin 16 in a dose-dependent manner in human skin organ cultures.
Gene_expression (expression) of cytokeratin 16 in skin associated with opiate
7) Confidence 0.58 Published 2003 Journal J. Invest. Dermatol. Section Abstract Doc Link 12535211 Disease Relevance 0.50 Pain Relevance 0.61
Different expression of mu-opiate receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression.
Gene_expression (expression) of cytokeratin 16 associated with injury and opiate
8) Confidence 0.58 Published 2003 Journal J. Invest. Dermatol. Section Title Doc Link 12535211 Disease Relevance 0.82 Pain Relevance 0.81
Cytokeratin 16 is expressed in hyperproliferative epidermis such as psoriasis and wound healing.
Gene_expression (expressed) of Cytokeratin 16 in epidermis associated with psoriasis and wound healing
9) Confidence 0.58 Published 2003 Journal J. Invest. Dermatol. Section Abstract Doc Link 12535211 Disease Relevance 0.70 Pain Relevance 0.62
Notably, the pathologic changes affect those tissues that constitutively express K6a and K16 (see above) but not the interfollicular epidermis.
Neg (not) Gene_expression (express) of K16 in epidermis
10) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.52 Pain Relevance 0.03
K6 and K16 are also consistently expressed in non-keratinizing stratified squamous epithelia (Moll et al. 1982b).
Gene_expression (expressed) of K16
11) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.10 Pain Relevance 0
However, quantitatively, squamous cell carcinomas rather embark on an alternative maturation pathway characterized by abundant expression of K6 and K16 (see above; Fig. 4d).
Gene_expression (expression) of K16 associated with skin cancer
12) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0
In the epidermis a regenerative epidermal differentiation program is induced that includes hyperproliferation and expression of genes such as cytokeratin 16 (CK16), SKALP/elafin, psoriasin and hBD-2 [9], [10].
Gene_expression (expression) of cytokeratin 16 in epidermis
13) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.97 Pain Relevance 0.30
In the epidermis a regenerative epidermal differentiation program is induced that includes hyperproliferation and expression of genes such as cytokeratin 16 (CK16), SKALP/elafin, psoriasin and hBD-2 [9], [10].
Gene_expression (expression) of CK16 in epidermis
14) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.97 Pain Relevance 0.31
The presence of keratin 16 suggests dysfunction in the leptomeningeal and choroid plexus epithelial system in CFS.
Gene_expression (presence) of keratin 16 in choroid plexus associated with chronic fatigue syndrome
15) Confidence 0.46 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.64 Pain Relevance 0.19
Among tumors, K6 and K16 are typically and strongly expressed in squamous cell carcinomas of different sites (Moll et al. 1982b; Moll 1998), preferentially in inner, maturing layers of the tumor cell nests (Fig. 4d).
Gene_expression (expressed) of K16 associated with cancer and skin cancer
16) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.01 Pain Relevance 0
K6/K16: keratins of hyperproliferative keratinocytes inducible in “activated” epidermis
Gene_expression (/) of K16 in epidermis
17) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.37 Pain Relevance 0
Another interesting feature of K17 is its inducibility after skin injury: after K6/K16 (see above), K17 is switched on in regenerating and migrating epidermal keratinocytes upon wound healing (Paladini et al. 1996).
Gene_expression (switched) of K16 in skin associated with wound healing and injury
18) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0.03
An objective statistical model was derived to predict CFS status based only on the proteomic detection of keratin 16, ?
Gene_expression (detection) of keratin 16 associated with chronic fatigue syndrome
19) Confidence 0.40 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.32 Pain Relevance 0.08
Thus, K6 (most probably K6a) and K16 are expressed in ductal luminal cells as well as in some secretory cells of human eccrine sweat glands (Fig. 5; Demirkesen et al. 1995; Langbein et al. 2005).
Gene_expression (expressed) of K16 in sweat glands
20) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.05

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