INT8664

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EDN3) extracellular space (EDN3) extracellular region (EDN3)
cell-cell signaling (EDN3)
Anatomy Link Frequency
epithelium 1
EDN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 84.56 Quite High
antagonist 2 83.20 Quite High
Potency 3 75.08 Quite High
Enkephalin 1 75.00 Quite High
tetrodotoxin 1 72.36 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In epithelium-denuded strips, preincubation with phosphoramidon did not further increase the maximal contractions induced by/or the potencies of ET-1, ET-2 or ET-3.
Neg (not) Positive_regulation (induced) of ET-3 in epithelium
1) Confidence 0.38 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1377128 Disease Relevance 0 Pain Relevance 0.22
One class (ET(A) receptor) had a high affinity for ET-1 and ET-2 but a low affinity for ET-3, and the other (ET(B) receptor) a high affinity for ET-1, ET-2 and ET-3.
Positive_regulation (affinity) of ET-3
2) Confidence 0.34 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11231044 Disease Relevance 0 Pain Relevance 0.15

General Comments

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