INT86640

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.50
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KRT16) cytoskeleton organization (KRT16)
Anatomy Link Frequency
skin 12
KRT16 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 32 99.12 Very High Very High Very High
Opioid 4 96.20 Very High Very High Very High
psoriasis 12 90.00 High High
medulla 14 51.44 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 24 100.00 Very High Very High Very High
Psoriasis 20 98.24 Very High Very High Very High
Wound Healing 8 97.48 Very High Very High Very High
Targeted Disruption 38 85.20 High High
Skin Diseases 8 84.56 Quite High
Skin Appendage Disease 6 38.80 Quite Low
Skin Cancer 58 35.36 Quite Low
Monilethrix 6 34.72 Quite Low
Apoptosis 22 33.20 Quite Low
Basal Cell Carcinoma 6 27.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, we show that beta-endorphin regulates cytokeratin 16 expression in the epidermis of skin organ cultures exposed to 41-125 nM beta-endorphin for 48 h, leading to elevated cytokeratin 16 production.
Positive_regulation (leading) of Gene_expression (production) of cytokeratin 16 in skin
1) Confidence 0.61 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.39 Pain Relevance 0.79
Secondly, we show that beta-endorphin regulates cytokeratin 16 expression in the epidermis of skin organ cultures exposed to 41-125 nM beta-endorphin for 48 h, leading to elevated cytokeratin 16 production.
Positive_regulation (elevated) of Gene_expression (production) of cytokeratin 16 in skin
2) Confidence 0.61 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.39 Pain Relevance 0.78
beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opiate receptor expression in human epidermis.
Positive_regulation (stimulates) of Gene_expression (expression) of cytokeratin 16 in epidermis associated with opiate
3) Confidence 0.44 Published 2000 Journal J. Invest. Dermatol. Section Title Doc Link 10692113 Disease Relevance 0.32 Pain Relevance 0.67
The same pattern was observed in psoriatic lesional skin, i.e., mu-opiate receptor expression was significantly downregulated and cytokeratin 16 expression upregulated.
Positive_regulation (upregulated) of Gene_expression (expression) of cytokeratin 16 in skin associated with psoriasis and opiate
4) Confidence 0.44 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.35 Pain Relevance 0.71
Another interesting feature of K17 is its inducibility after skin injury: after K6/K16 (see above), K17 is switched on in regenerating and migrating epidermal keratinocytes upon wound healing (Paladini et al. 1996).
Positive_regulation (inducibility) of Gene_expression (switched) of K16 in skin associated with wound healing and injury
5) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0.03
Another interesting feature of K17 is its inducibility after skin injury: after K6/K16 (see above), K17 is switched on in regenerating and migrating epidermal keratinocytes upon wound healing (Paladini et al. 1996).
Positive_regulation (after) of Gene_expression (switched) of K16 in skin associated with wound healing and injury
6) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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