INT86644

Context Info Confidence 0.28 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.58

plasma membrane (OPRD1, DLL1) cell differentiation (DLL1) extracellular region (DLL1) cell-cell signaling (DLL1) cytoplasm (OPRD1) signal transducer activity (OPRD1)

OPRD1 (Homo sapiens) DLL1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 3 100.00 antagonist 2 100.00 MU agonist 1 100.00 agonist 1 91.12 opioid receptor 4 82.40 Potency 1 80.56 adenocard 1 78.80 Enkephalin 1 48.72

Disease Link Frequency Relevance Heat Neuroblastoma 2 95.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Binding experiments using "selective" delta1- and delta2-opioid agonists and antagonists revealed the presence of two binding sites, demonstrating the presence of these delta1-opioid subtypes as they were previously described.

delta1-opioid Binding (presence) of delta1 associated with mu agonist, antagonist and opioid

1) Confidence 0.28 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10692556 Disease Relevance 0.17 Pain Relevance 0.58

General Comments

This test has worked.