INT86646

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 71
Total Number 75
Disease Relevance 50.61
Pain Relevance 13.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN10A) transmembrane transport (SCN10A)
Anatomy Link Frequency
SNS 17
heart 6
sympathetic 3
limb 2
SNs 2
SCN10A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 80 100.00 Very High Very High Very High
Neuropeptide 19 100.00 Very High Very High Very High
nav1.8 10 100.00 Very High Very High Very High
hyperexcitability 8 100.00 Very High Very High Very High
sodium channel 39 99.96 Very High Very High Very High
addiction 3 99.92 Very High Very High Very High
allodynia 2 99.62 Very High Very High Very High
tetrodotoxin 17 99.42 Very High Very High Very High
Hyperalgesia 2 99.34 Very High Very High Very High
backache 6 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 2301 100.00 Very High Very High Very High
Pressure And Volume Under Development 69 100.00 Very High Very High Very High
Injury 45 100.00 Very High Very High Very High
Nociception 7 100.00 Very High Very High Very High
Syndrome 263 99.96 Very High Very High Very High
Atherosclerosis 5 99.92 Very High Very High Very High
Myocardial Infarction 126 99.88 Very High Very High Very High
Hypoglycemia 233 99.76 Very High Very High Very High
Appetite Loss 19 99.76 Very High Very High Very High
Nervous System Injury 4 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, the findings from these studies suggest that SNS activation may facilitate, and SNS inhibition inhibit, the early stages of sexual arousal in sexually functional women and in women with low sexual desire.
Positive_regulation (activation) of SNS in SNS associated with hypoactive sexual desire disorder
1) Confidence 0.69 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10899275 Disease Relevance 0.09 Pain Relevance 0.31
Upregulation and colocalization of p75 and Nav1.8 in Purkinje neurons in experimental autoimmune encephalomyelitis.
Positive_regulation (Upregulation) of Nav1.8 in neurons associated with multiple sclerosis and nav1.8
2) Confidence 0.67 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15464262 Disease Relevance 1.16 Pain Relevance 0.42
However, the extent and the pattern of SNS activation varied significantly.
Positive_regulation (activation) of SNS
3) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.89 Pain Relevance 0.08
However, the efficacy and the patterns of SNS activation have not been systematically compared between different tasks.
Positive_regulation (activation) of SNS in SNS
4) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Abstract Doc Link PMC2577930 Disease Relevance 0.32 Pain Relevance 0
However, this does not change our assumption that affective pictures only minimally activate the SNS although they are considered as stressful.


Positive_regulation (activate) of SNS
5) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.66 Pain Relevance 0
Moreover, the CWT is the only test, which activates the SNS even in addition to viewing neutral IAPS pictures, which serves as “control” condition in our study.
Positive_regulation (activates) of SNS
6) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.46 Pain Relevance 0.05
Undoubtedly, all these tasks induce SNS activation in general.
Positive_regulation (activation) of SNS
7) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.38 Pain Relevance 0
When compared to neutral affective pictures, an increase of SNS activity during mental arithmetic was only found for emotional sweating and heart rate.


Positive_regulation (increase) of SNS in heart
8) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.52 Pain Relevance 0.04
We found that all common stress tasks under investigation activated the SNS.
Positive_regulation (activated) of SNS associated with stress
9) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.91 Pain Relevance 0.08
However, our results indicate that pictures of both valences induced only minor SNS activation.
Positive_regulation (activation) of SNS
10) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.52 Pain Relevance 0.04
Perception of SNS activation might subsequently even reinforce stress perception [38].
Positive_regulation (activation) of SNS associated with stress
11) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.83 Pain Relevance 0.04
In conclusion, our study demonstrates that activation of the SNS during stress tasks might vary significantly – depending on the task and the SNS parameter under investigation.
Positive_regulation (activation) of SNS associated with stress
12) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.72 Pain Relevance 0.07
The other tests, even if perceived as more stressful, activated the SNS less reliably.
Positive_regulation (activated) of SNS
13) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.48 Pain Relevance 0.05
Our results show that the activation of the SNS widely varies depending on the stress task.
Positive_regulation (activation) of SNS in SNS associated with stress
14) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Abstract Doc Link PMC2577930 Disease Relevance 0.75 Pain Relevance 0
However, SNS activation was not reliable: Affective pictures did not induce a significant SNS response; singing, giving a talk and mental arithmetic selectively increased heart rate and emotional sweating.
Positive_regulation (activation) of SNS in heart associated with heart rate under development
15) Confidence 0.61 Published 2008 Journal The Open Neurology Journal Section Abstract Doc Link PMC2577930 Disease Relevance 0.74 Pain Relevance 0
These results indicate that DIT due to CH-19 Sweet can be induced via the activation of SNS as well as hot red pepper, but that the changes in BP, HR, and heat loss effect are different between these peppers.
Positive_regulation (activation) of SNS in SNS
16) Confidence 0.60 Published 2007 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 17341828 Disease Relevance 0 Pain Relevance 0
Accumulation of PN1 and PN3 sodium channels in painful human neuroma-evidence from immunocytochemistry.
Positive_regulation (Accumulation) of PN3 associated with pain, neuropeptide, sodium channel and neuroma
17) Confidence 0.60 Published 2002 Journal Acta Neurochir (Wien) Section Title Doc Link 12181690 Disease Relevance 0.35 Pain Relevance 0.78
However, increased SNS activity is typically associated with reductions in energy intake and increased energy expenditure over time [54].
Positive_regulation (increased) of SNS
18) Confidence 0.59 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.51 Pain Relevance 0
Increased SNS activity also inhibits vagal nerve activity, which could account for the rise in ghrelin level observed with sleep loss [52, 53].
Positive_regulation (Increased) of SNS in vagal nerve
19) Confidence 0.59 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.52 Pain Relevance 0
The activation of the SNS with sleep restriction is one possibility since increased SNS activity inhibits the release of leptin from adipose tissue and may inhibit insulin release [51].
Positive_regulation (increased) of SNS in adipose tissue associated with obesity
20) Confidence 0.59 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.52 Pain Relevance 0

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