INT86662

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) plasma membrane (SCN10A) molecular_function (Ngf)
Anatomy Link Frequency
nerve 1
Ngf (Rattus norvegicus)
SCN10A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 10 100.00 Very High Very High Very High
sodium channel 1 99.90 Very High Very High Very High
Inflammation 4 99.28 Very High Very High Very High
Trk A 5 94.40 High High
Quantitative sensory testing 1 78.96 Quite High
nociceptor 2 66.36 Quite High
Pain 6 56.04 Quite High
unmyelinated 1 54.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.28 Very High Very High Very High
Hypersensitivity 1 98.44 Very High Very High Very High
Mycobacterium Infection 9 98.14 Very High Very High Very High
Nociception 1 75.00 Quite High
Pain 3 56.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, NGF-immunoreactivity in basal keratinocytes, and intra-epidermal PGP 9.5-positive nerve fibres, were reduced in both sites compared to non-leprosy controls, as were nerve fibres positive for the sensory neurone specific sodium channel SNS/PN3, which is regulated by NGF, and may mediate inflammation-induced hypersensitivity.
NGF Regulation (regulated) of PN3 in nerve associated with inflammation, nerve growth factor, mycobacterium infection, hypersensitivity and sodium channel
1) Confidence 0.27 Published 2000 Journal Pain Section Abstract Doc Link 10692623 Disease Relevance 1.24 Pain Relevance 0.99

General Comments

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