INT86670

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.24
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (AGXT) small molecule metabolic process (AGXT) peroxisome (AGXT)
cellular nitrogen compound metabolic process (AGXT)
Anatomy Link Frequency
Liver 1
lymphocytes 1
AGXT (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 62 99.78 Very High Very High Very High
b2 receptor 3 99.40 Very High Very High Very High
Hsan 101 99.36 Very High Very High Very High
bradykinin 41 95.80 Very High Very High Very High
Peripheral nervous system 1 74.76 Quite High
Pain 5 72.32 Quite High
isoflurane 6 69.76 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
unmyelinated 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 114 99.36 Very High Very High Very High
Urolithiasis 1 99.04 Very High Very High Very High
Renal Failure 2 88.00 High High
Death 1 83.92 Quite High
Apoptosis 2 83.36 Quite High
Necrosis 6 82.24 Quite High
Stress 1 76.56 Quite High
Disease 27 75.00 Quite High
Polyradiculoneuropathy 2 75.00 Quite High
Hyperoxaluria 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver biopsy showed a decrease in catalytic activity of the hepatic peroxisomal enzyme alanine: glyoxilate aminotransferase (AGT), which was mistargeted from peroxisomes to mitochondria.
Negative_regulation (decrease) of AGT in Liver
1) Confidence 0.57 Published 2000 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 10693261 Disease Relevance 0.53 Pain Relevance 0.07
We demonstrate that also V144D has a reduced SPT activity, however to a lower extent than C133W and C133Y.
Negative_regulation (reduced) of SPT
2) Confidence 0.43 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19132419 Disease Relevance 0.69 Pain Relevance 0.18
Potent inhibitors of SPT structurally resemble an intermediate in a probable multistep reaction mechanism for SPT.
Negative_regulation (inhibitors) of SPT
3) Confidence 0.36 Published 2003 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12782147 Disease Relevance 0.29 Pain Relevance 0.07
Their tests using cells from HSN I patients with the mutation T399G-(Cys133Trp) in the SPTLC1 gene revealed a reduction of SPT activity in transformed lymphocytes of 44%.
Negative_regulation (reduction) of SPT in lymphocytes associated with hsan
4) Confidence 0.16 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.50 Pain Relevance 0.19
Pre-treatment with adenosine receptors inhibitor (SPT) and specific B2 bradykinin receptor' inhibitor (HOE140) abolished desflurane-induced PostC.
Negative_regulation (inhibitor) of SPT associated with adenocard and b2 receptor
5) Confidence 0.03 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0 Pain Relevance 0.43
Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5'-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p.
Negative_regulation (inactivate) of SPT associated with hsan
6) Confidence 0.02 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11781309 Disease Relevance 0.23 Pain Relevance 0.23

General Comments

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