INT86671

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.83
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
thymus 4
spinal cord 2
brain 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 9 100.00 Very High Very High Very High
ischemia 6 100.00 Very High Very High Very High
Opioid 11 99.98 Very High Very High Very High
Neurobehavioral 1 84.28 Quite High
narcan 1 83.08 Quite High
antagonist 1 82.72 Quite High
opioid receptor 4 79.28 Quite High
Enkephalin 1 78.84 Quite High
agonist 2 77.68 Quite High
withdrawal 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 22 100.00 Very High Very High Very High
Spinal Cord Ischemia 6 100.00 Very High Very High Very High
Reperfusion Injury 1 100.00 Very High Very High Very High
Cerebral Hypoxia 1 99.62 Very High Very High Very High
Autism 82 98.96 Very High Very High Very High
Stress 39 96.12 Very High Very High Very High
Hypoxia 4 94.52 High High
Neurodegenerative Disease 1 85.80 High High
Pheochromocytoma 1 68.40 Quite High
Death 1 59.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, opioids prevented the elevation of the Bcl-2 and Bak proteins following serum deprivation to the levels attained by serum supplementation.
Negative_regulation (prevented) of Positive_regulation (elevation) of Bcl-2 associated with opioid
1) Confidence 0.57 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10693926 Disease Relevance 0.47 Pain Relevance 1.18
We conclude that HBO-PC reduced spinal cord ischemia-reperfusion injury by increasing Mn-SOD, catalase, and Bcl-2, and by suppressing mitochondrial apoptosis pathway.
Negative_regulation (reduced) of Positive_regulation (increasing) of Bcl-2 in spinal cord associated with reperfusion injury, ischemia, apoptosis and spinal cord
2) Confidence 0.31 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19196076 Disease Relevance 0.92 Pain Relevance 0.62
CONCLUSION: EA at "Zusanli" (ST 36) can inhibit morphine-induced downregulation of Bcl-2 and upregulation of Fas and FasL expression, which may contribute to its effect in resisting thymus apoptosis in morphine withdrawal rats.


Negative_regulation (downregulation) of Positive_regulation (upregulation) of Bcl-2 in thymus
3) Confidence 0.21 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0 Pain Relevance 0
CONCLUSION: EA at "Zusanli" (ST 36) can inhibit morphine-induced downregulation of Bcl-2 and upregulation of Fas and FasL expression, which may contribute to its effect in resisting thymus apoptosis in morphine withdrawal rats.


Negative_regulation (inhibit) of Positive_regulation (upregulation) of Bcl-2 in thymus
4) Confidence 0.21 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0 Pain Relevance 0
There are several studies that demonstrate evidence of cerebral hypoxia, as measured by a reduction in brain Bcl-2 and an increase in brain p53, among some autistic individuals [68-71].
Negative_regulation (reduction) of Positive_regulation (increase) of Bcl-2 in brain associated with autism and cerebral hypoxia
5) Confidence 0.07 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC2244616 Disease Relevance 1.68 Pain Relevance 0
Inhibition of ERK prevented the DADLE-induced decrease in apoptosis and Bax translocation, and increase in survivin and Bcl-2.
Negative_regulation (decrease) of Positive_regulation (increase) of Bcl-2 associated with apoptosis
6) Confidence 0.06 Published 2007 Journal J. Cell. Sci. Section Abstract Doc Link 17298978 Disease Relevance 0.76 Pain Relevance 0.23

General Comments

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