INT86673

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 77
Total Number 77
Disease Relevance 57.74
Pain Relevance 17.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
neuronal 4
NSCs 3
apoptotic cells 2
spinal cord 2
ventricles 1
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 163 99.98 Very High Very High Very High
Morphine 25 99.98 Very High Very High Very High
Kinase C 42 99.80 Very High Very High Very High
Opioid 19 99.70 Very High Very High Very High
fluoxetine 31 99.60 Very High Very High Very High
ischemia 433 99.54 Very High Very High Very High
Hippocampus 64 99.44 Very High Very High Very High
Spinal cord 56 99.36 Very High Very High Very High
opioid receptor 14 99.20 Very High Very High Very High
cytokine 80 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 884 100.00 Very High Very High Very High
Injury 252 99.92 Very High Very High Very High
Reperfusion Injury 30 99.92 Very High Very High Very High
Hepatocellular Cancer 6 99.92 Very High Very High Very High
Hypoxia 156 99.90 Very High Very High Very High
Synovial Sarcoma 15 99.80 Very High Very High Very High
Hepatotoxicity 23 99.72 Very High Very High Very High
Diabetes Mellitus 205 99.64 Very High Very High Very High
Spinal Cord Ischemia 6 99.54 Very High Very High Very High
Death 265 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The in vitro observation and immunofluorescent study further demonstrated that FL treatment can stimulate the neurite development and serotoninergic differentiation of NSCs through the activation of Bcl-2.
Positive_regulation (activation) of Bcl-2 in NSCs associated with fluoxetine
1) Confidence 0.70 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.33 Pain Relevance 0.90
Data analysis revealed that Bax/Bcl2 ratio was increased in all of the morphine-exposed groups.
Positive_regulation (increased) of Bcl2 associated with morphine
2) Confidence 0.69 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.20 Pain Relevance 0.74
In the PND50 brain, A1254 at 0.1 mg/kg/day reduced Bcl2 expression in the female cortex (Figure 5B), whereas both A1254 doses increased Bcl2 in the male cortex (Figure 5D).
Positive_regulation (increased) of Bcl2 in cortex
3) Confidence 0.68 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.23 Pain Relevance 0.03
Finally, opioids prevented the elevation of the Bcl-2 and Bak proteins following serum deprivation to the levels attained by serum supplementation.
Positive_regulation (elevation) of Bcl-2 associated with opioid
4) Confidence 0.67 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10693926 Disease Relevance 0.47 Pain Relevance 1.17
In the CeA, again in direct contrast to the stress effects, exposure to all classes of ADTs significantly increased Bcl-2 mRNA.
Positive_regulation (increased) of Bcl-2 mRNA in CeA associated with stress and amygdala
5) Confidence 0.62 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.76 Pain Relevance 0.59
In contrast, nonresponding patients showed upregulation of bcl-2mRNA and no change in Bcl-2 protein levels.
Positive_regulation (upregulation) of bcl-2mRNA
6) Confidence 0.56 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.68 Pain Relevance 0
Our results showed that 20 microM FL treatment can significantly increase the proliferation rate of NSCs (p<0.05), and up-regulate the mRNA and protein expressions of Bcl-2 in Day-7 FL-treated NSCs (p<0.01).
Positive_regulation (up-regulate) of Bcl-2 in NSCs associated with fluoxetine
7) Confidence 0.50 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.40 Pain Relevance 0.95
Mechanism(s) implicated in at least some types of preconditioning include increased Bcl2 and Cyp2C11 expression (Koerner and Alkayed 2007).
Positive_regulation (increased) of Bcl2
8) Confidence 0.49 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.57 Pain Relevance 0.06
An immunohistochemical study showed that the lymphoma cells were positive for leukocyte common antigen, Epstein-Barr virus, bax. and bcl-XL, and negative for L-26 and bcl-2.
Positive_regulation (negative) of bcl-2 in leukocyte associated with lymphatic system cancer
9) Confidence 0.49 Published 1999 Journal Brain Tumor Pathol Section Abstract Doc Link 10746967 Disease Relevance 1.11 Pain Relevance 0.24
Effects of L-arginine in expression of Bcl-2 mRNA and protein
Positive_regulation (arginine) of Bcl-2
10) Confidence 0.48 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.78 Pain Relevance 0.14
Group 1 had increased bcl-2 and bax protein expression in hippocampal CA1 region at 6 h after CPB (bcl-2, 0.18 +/- 0.05 versus 0.09 +/- 0.01; P = 0.02; bax, 0.20 +/- 0.06 versus 0.04 +/- 0.02; P = 0.01; Group 1 versus Group 2, respectively).
Positive_regulation (had) of bcl-2
11) Confidence 0.47 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.28 Pain Relevance 0.21
Group 1 had increased bcl-2 and bax protein expression in hippocampal CA1 region at 6 h after CPB (bcl-2, 0.18 +/- 0.05 versus 0.09 +/- 0.01; P = 0.02; bax, 0.20 +/- 0.06 versus 0.04 +/- 0.02; P = 0.01; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of bcl-2
12) Confidence 0.47 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.28 Pain Relevance 0.21
Using Bcl-2 gene silencing with small interfering RNA, our data verified that FL can prevent Fas ligand-induced caspase-dependent apoptosis in NSCs through the activation of Bcl-2.
Positive_regulation (activation) of Bcl-2 in NSCs associated with apoptosis and fluoxetine
13) Confidence 0.47 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.38 Pain Relevance 0.96
Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos.
Positive_regulation (increases) of Bcl-2 in embryos associated with morphine
14) Confidence 0.46 Published 2010 Journal J. Mol. Neurosci. Section Title Doc Link 19936637 Disease Relevance 0.17 Pain Relevance 0.51
In the central nervous system, however, the role of Bcl-2 in response to neuronal injury is unclear because both increases and decreases in Bcl-2 levels have been described.
Positive_regulation (increases) of Bcl-2 in neuronal associated with injury and central nervous system
15) Confidence 0.46 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.83 Pain Relevance 0.35
The expression of Bcl-2 family proteins, activation of caspase-3, and 4-hydroxy-2-nonenal (4-HNE)-modified proteins were assessed by Western blot analysis.
Positive_regulation (activation) of Bcl-2
16) Confidence 0.45 Published 2009 Journal Digestion Section Body Doc Link 19401612 Disease Relevance 0.24 Pain Relevance 0
Nimesulide exposure increased intracellular ROS, translocation of Bax and Bcl2 followed by mitochondrial depolarization and cytochrome c (Cyt c) release along with caspase-9/-3 activity confirming involvement of mitochondria in nimesulide induced apoptosis.
Positive_regulation (increased) of Bcl2 associated with apoptosis
17) Confidence 0.45 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19772912 Disease Relevance 0.75 Pain Relevance 0.07
Thus, it may be concluded that L-arginine afforded significant protection from necrosis and apoptosis in I/R injury by upregulated Bcl-2 gene and nitric oxide production.



Positive_regulation (upregulated) of Bcl-2 associated with necrosis, injury and apoptosis
18) Confidence 0.45 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Abstract Doc Link PMC2841413 Disease Relevance 1.14 Pain Relevance 0.07
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of bcl-2
19) Confidence 0.44 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of bcl-2
20) Confidence 0.44 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24

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