INT8668

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.36
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
blood 2
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 7 91.76 High High
pruritus 5 85.52 High High
Bile 44 80.92 Quite High
Paracetamol 1 72.16 Quite High
Inflammatory marker 1 59.56 Quite High
nud 6 45.88 Quite Low
aspirin 5 17.36 Low Low
Bioavailability 10 11.60 Low Low
cva 14 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 691 100.00 Very High Very High Very High
Coronary Artery Disease 218 98.20 Very High Very High Very High
Hyperlipidemia 33 94.80 High High
Death 33 94.40 High High
Increased Venous Pressure Under Development 39 93.04 High High
Dyslipidemia /

Combined Dyslipidemia

64 91.92 High High
Headache 7 91.76 High High
Pressure And Volume Under Development 10 90.48 High High
Fatty Liver 1 75.44 Quite High
Hypertension 9 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the effects of fibric acid derivatives on the lipid profile primarily involve triglyceride reduction, significant increases in HDL-C, varying effects on LDL-C levels, and improvement in LDL-C particle size have also been observed (Vakkilainen et al 2003).
Regulation (effects) of Positive_regulation (increases) of HDL associated with disorder of lipid metabolism
1) Confidence 0.44 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.25 Pain Relevance 0.15
1-HDL ratio is a signature pattern of disturbed HDL metabolism and RCT, implying that higher concentrations of HDL-C do not correct the abnormal HDL subclass distribution for subjects with high levels of LDL-C (?
Neg (not) Regulation (correct) of Positive_regulation (concentrations) of HDL associated with disorder of lipid metabolism
2) Confidence 0.31 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.90 Pain Relevance 0
After 3 months of treatment, we found (a) significant decreases in systolic (147 +/- 18 vs. 166 +/- 16 mm Hg, p less than 0.001) and diastolic blood pressure (90 +/- 8 vs. 107 +/- 8 mm Hg, p less than 0.0007), triglycerides (107 +/- 47 vs. 120 +/- 49 mg/dl, p less than 0.0007), and cholesterol (236 +/- 4 vs. 257 +/- 44 mg/dl, p less than 0.00075) in blood, and in K excretion (50 +/- 19 vs. 46 +/- 19 mEq/g of creatinine, p less than 0.0007) and excreted fraction of K (49 +/- 6% vs. 8 +/- 5%, p less than 0.0012) in urine; (b) significant increases in HDL cholesterol (65 +/- 13 vs. 58 +/- 13 mg/dl, p less than 0.001) in blood, and in Na (115 +/- 73 vs. 109 +/- 69 mEq/g of creatinine, p less than 0.0007) in urine; and (c) no significant change in the remaining biochemical parameters, or in heart rate.
Regulation (change) of Positive_regulation (increases) of HDL in blood associated with disorder of lipid metabolism
3) Confidence 0.26 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1377308 Disease Relevance 0.64 Pain Relevance 0.13
On the other hand, niacin and fibric acid are more effective in increasing HDL-C and decreasing TG than the other classes of drugs.
Regulation (effective) of Positive_regulation (increasing) of HDL associated with disorder of lipid metabolism
4) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.60 Pain Relevance 0.04
The investigators proposed that the decreases in TC and LDL-C accounted for the majority of the benefit, while the small increase in HDL-C (about 3%) accounted for a 2% decrease in CHD.


Regulation (accounted) of Positive_regulation (increase) of HDL associated with coronary artery disease and disorder of lipid metabolism
5) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.58 Pain Relevance 0
Fenofibrate as monotherapy decreases serum TG levels by 20%–50% and increases HDL-C levels by 10%–50%.48,70,71 The rise in HDL-C levels depends on baseline HDL-C concentrations, with the greatest elevations observed when baseline HDL-C is <39 mg/dL (1.03 mmol/L).72 It also decreases LDL-C levels by 5%–20%.73 LDL-C response is directly related to baseline LDL-C levels and inversely related to baseline TG levels.73 In clinical practice, TG reduction is greater in hypertriglyceridemia phenotypes (up to 50%) and lower in Type IIa hypercholesterolemia (<30%).
Regulation (depends) of Positive_regulation (increases) of HDL associated with hyperlipidemia and disorder of lipid metabolism
6) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.21 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox