INT86698

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 38
Total Number 46
Disease Relevance 16.37
Pain Relevance 11.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
colon 5
sciatic nerves 3
temporomandibular joint 2
bowel 2
muscle cells 2
Cav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Delta opioid receptors 1 99.98 Very High Very High Very High
Neuritis 56 99.84 Very High Very High Very High
Snapping jaw 8 99.78 Very High Very High Very High
IPN 11 99.72 Very High Very High Very High
Inflammation 74 99.68 Very High Very High Very High
Pain 16 99.68 Very High Very High Very High
Sciatic nerve 38 99.28 Very High Very High Very High
dorsal root ganglion 6 99.00 Very High Very High Very High
tail-flick 8 98.52 Very High Very High Very High
opioid receptor 1 97.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 56 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 8 99.78 Very High Very High Very High
Inflammatory Pain 6 99.72 Very High Very High Very High
INFLAMMATION 75 99.60 Very High Very High Very High
Pulmonary Hypertension 600 99.48 Very High Very High Very High
Ganglion Cysts 12 99.20 Very High Very High Very High
Apoptosis 23 98.44 Very High Very High Very High
Hypertrophy 144 98.24 Very High Very High Very High
Cv Unclassified Under Development 25 97.00 Very High Very High Very High
Nociception 4 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This immunocytochemical study revealed the expression of caveolin-1, a major protein of caveolae, in the rat temporomandibular joint.
Gene_expression (expression) of caveolin-1 in temporomandibular joint associated with snapping jaw
1) Confidence 0.78 Published 2006 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 16342213 Disease Relevance 0.25 Pain Relevance 0.17
Expression of caveolin-1 in the rat temporomandibular joint.
Gene_expression (Expression) of caveolin-1 in temporomandibular joint associated with snapping jaw
2) Confidence 0.78 Published 2006 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Title Doc Link 16342213 Disease Relevance 0.28 Pain Relevance 0.19
Changes in gene expression of caveolin-1 after inflammatory pain using quantitative real-time PCR.
Gene_expression (expression) of caveolin-1 associated with inflammation and ipn
3) Confidence 0.78 Published 2010 Journal Methods Mol. Biol. Section Title Doc Link 20300998 Disease Relevance 0.18 Pain Relevance 0.43
The result of this experiment shows that there was a twofold increase in caveolin-1 gene expression in rat dorsal root ganglions 24 h after Complete Freund's Adjuvant administration and a decrease at 48 h.
Gene_expression (expression) of caveolin-1 gene in dorsal root ganglions associated with ganglion cysts
4) Confidence 0.78 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20300998 Disease Relevance 0.25 Pain Relevance 0.15
It specifically describes the process by which real-time PCR was used to measure caveolin-1 gene expression after an inflammatory pain insult.
Gene_expression (expression) of caveolin-1 gene associated with ipn
5) Confidence 0.78 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20300998 Disease Relevance 0.17 Pain Relevance 0.17
Consequently, we postulated that caveolin-1 expression increased in the sciatic nerves with EAN; this possibly mediated either molecular trafficking or nitric oxide generation partly through the activation of eNOS in vascular endothelial cells, as well as in inflammatory macrophages in EAN and/or cellular apoptosis of inflammatory cells.
Gene_expression (expression) of caveolin-1 in endothelial cells associated with inflammation, sciatic nerve, apoptosis and neuritis
6) Confidence 0.76 Published 2006 Journal Brain Res. Section Abstract Doc Link 16806125 Disease Relevance 1.13 Pain Relevance 0.98
The expression of caveolin-1 and the related molecule endothelial nitric oxide synthase (eNOS) was analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN).
Spec (analyzed) Gene_expression (expression) of caveolin-1 in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
7) Confidence 0.76 Published 2006 Journal Brain Res. Section Abstract Doc Link 16806125 Disease Relevance 0.54 Pain Relevance 0.59
Our recent study on the temporomandibular joint (TMJ) revealed expressions of Cav1 and muscle-specific Cav3 in some synovial fibroblast-like type B cells with well-developed caveolae.
Gene_expression (expressions) of Cav1 in muscle associated with snapping jaw
8) Confidence 0.74 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18286598 Disease Relevance 0.35 Pain Relevance 0.35
Immunohistochemistry showed intense p-caveolin-1 immunostaining in some inflammatory macrophages, as well as in T-cells in individual nerve fascicles at the peak stage of EAN, while p-caveolin-1 was weakly expressed in some of the vascular endothelial cells and Schwann cells of normal sciatic nerves.
Gene_expression (expressed) of p-caveolin-1 in inflammatory macrophages associated with inflammation, sciatic nerve and neuritis
9) Confidence 0.68 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 1.02 Pain Relevance 0.92
The inflammatory cells with intense p-caveolin-1 expression in the EAN-affected individual nerve fascicles were not positive for terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL), while the TUNEL-positive apoptotic cells in the perineurium, where infiltration initially occurred, were weakly positive for p-caveolin-1.
Gene_expression (expression) of p-caveolin-1 in nerve associated with inflammation, apoptosis and neuritis
10) Confidence 0.68 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 1.08 Pain Relevance 0.96
Kyo, Tyr-cav, Tyr(Cl2)-cav, L-canavanine (L-cav) and D-arg were applied in rats intracerebroventricularly (i.c.v.) at a dose of 20 microg/20 microl.
Gene_expression (applied) of cav
11) Confidence 0.65 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15319811 Disease Relevance 0.19 Pain Relevance 0.96
Kyo, Tyr-cav, Tyr(Cl2)-cav, L-canavanine (L-cav) and D-arg were applied in rats intracerebroventricularly (i.c.v.) at a dose of 20 microg/20 microl.
Gene_expression (applied) of cav
12) Confidence 0.65 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15319811 Disease Relevance 0.19 Pain Relevance 0.95
To study whether in vivo modulation of Cav-1 expression could affect the development of PAH and RV hypertrophy, rats were injected with MCT, followed by a daily injection of (1) saline, (2) a peptide corresponding to the homeodomain of the Drosophila transcription factor antennapedia (AP; 2.5?
Gene_expression (expression) of Cav-1 associated with hypertrophy and pulmonary hypertension
13) Confidence 0.65 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.84 Pain Relevance 0
In several animal models of PAH and in patients with severe PAH, reductions in pulmonary Cav-1 expression were apparent.
Gene_expression (expression) of Cav-1 associated with pulmonary hypertension
14) Confidence 0.65 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.78 Pain Relevance 0
Cav1.2 and Cav1.3 were positively expressed in colon of both model group and control group rats.
Gene_expression (expressed) of Cav1 in colon
15) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137275 Disease Relevance 0.13 Pain Relevance 0
Cav1.2 and Cav1.3 were positively expressed in colon of both model group and control group rats.
Gene_expression (expressed) of Cav1 in colon
16) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137275 Disease Relevance 0.13 Pain Relevance 0
The expressions of Cav1.2 and Cav1.3 were examined by immunohistochemistry in colonic tissues from D-IBS model rats and matched tissues.
Spec (examined) Gene_expression (expressions) of Cav1
17) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137275 Disease Relevance 0.16 Pain Relevance 0
The immunohistochemical scores of Cav1.3 expression were significantly higher than Cav1.2 in colon of both two group rats (P = 0.003, 0.005).
Gene_expression (expression) of Cav1 in colon
18) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137275 Disease Relevance 0.10 Pain Relevance 0
The immunohistochemical scores of Cav1.2 and Cav1.3 expression increased in colon of D-IBS model rats as compared with those in normal control rats (3.43 +/- 0.92 vs 2.82 +/- 0.60, P = 0.034, 4.32 +/- 0.51 vs 3.75 +/- 1.05, P = 0.039).
Gene_expression (expression) of Cav1 in colon
19) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137275 Disease Relevance 0.12 Pain Relevance 0
The expressions of Cav1.2 and Cav1.3 were examined by immunohistochemistry in colonic tissues from D-IBS model rats and matched tissues.
Spec (examined) Gene_expression (expressions) of Cav1
20) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137275 Disease Relevance 0.16 Pain Relevance 0

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