INT867

Context Info Confidence 0.78 First Reported 1975 Last Reported 2011 Negated 22 Speculated 12 Reported most in Abstract Documents 930 Total Number 946 Disease Relevance 594.85 Pain Relevance 168.03

Anatomy Link Frequency T cells 59 lung 19 leukocyte 15 NK cells 15 macrophages 9 IFNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 12547 100.00 rheumatoid arthritis 11970 100.00 Inflammation 9284 100.00 Paracetamol 1864 100.00 Central nervous system 1339 100.00 depression 405 100.00 Inflammatory mediators 317 100.00 isoflurane 25 100.00 methotrexate 699 99.98 Somatostatin 223 99.98

Disease Link Frequency Relevance Heat Infection 13771 100.00 Cancer 13331 100.00 Rheumatoid Arthritis 12001 100.00 INFLAMMATION 9818 100.00 Hepatitis C Virus Infection 5952 100.00 Apoptosis 3913 100.00 Systemic Lupus Erythematosus 3480 100.00 Skin Cancer 1231 100.00 Necrosis 1104 100.00 Hepatocellular Cancer 1049 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Serum IFN was undetectable after single doses of 1 x 10(6) to 18 x 10(6) IU, but 60 x 10(6) IU resulted in measurable levels of circulating IFN in 3 out of 6 patients.

Gene_expression (undetectable) of IFN

1) Confidence 0.78 Published 1989 Journal J. Interferon Res. Section Abstract Doc Link 2546997 Disease Relevance 0.31 Pain Relevance 0.07

The interferon was produced in leukocyte cultures and was given intramuscularly in one daily dose of 1 million units for 5-8 days.

Gene_expression (produced) of interferon in leukocyte

2) Confidence 0.77 Published 1975 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 1096292 Disease Relevance 0.30 Pain Relevance 0.06

In the interferon-treated patients interferon was detectable in serum (peak level 1-5 hours after interferon injections) and in vesicle fluid, and in some patients also in urine samples.

Gene_expression (detectable) of interferon in urine

3) Confidence 0.77 Published 1975 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 1096292 Disease Relevance 0.32 Pain Relevance 0.07

In vitro exposure of rodent and human lymphocytes to cannabinoids depresses their transformation, natural killer activity, and interferon production.

Gene_expression (production) of interferon in lymphocytes associated with cannabinoid

4) Confidence 0.77 Published 1987 Journal Adv Alcohol Subst Abuse Section Abstract Doc Link 3329450 Disease Relevance 0.15 Pain Relevance 0.42

From Trypanosoma brucei brucei, a molecule has been isolated which triggers the production of IFN-gamma by CD8+ T-cells.

Gene_expression (production) of IFN in T-cells

5) Confidence 0.75 Published 1994 Journal Bull Soc Pathol Exot Section Abstract Doc Link 7496193 Disease Relevance 0.21 Pain Relevance 0.12

Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-gamma and soluble CD14 in the serum were analysed by ELISA technique.

Spec (analysed) Gene_expression (Levels) of IFN

6) Confidence 0.75 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072982 Disease Relevance 0 Pain Relevance 0

Via interaction with Toll-like receptor 7 on immune cells, imiquimod induces local production of cytokines, such as interferon (IFN)-alpha.

Gene_expression (production) of IFN in immune cells associated with cytokine

7) Confidence 0.75 Published 2004 Journal Clin. Cancer Res. Section Abstract Doc Link 15297396 Disease Relevance 0.17 Pain Relevance 0.12

At 24 hr, a massive neutrophil recruitment and an induced expression of a wide spectrum of murine cytokine mRNA (i.e., interleukin [IL]-1 beta, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor [TNF]-alpha and interferon [IFN]-gamma) occurred in the huPBL-SCID mouse peritoneal cavity.

Gene_expression (expression) of IFN in peritoneal cavity associated with necrosis, cancer, severe combined immunodeficiency and cytokine

8) Confidence 0.75 Published 1995 Journal Transplantation Section Abstract Doc Link 8525526 Disease Relevance 0.71 Pain Relevance 0.13

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Gene_expression (synthesis) of IFN associated with necrosis, anesthesia and cancer

9) Confidence 0.75 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.53

Recently, it has been shown that the complex of the four glycoproteins gB, gD, gH and gL, which are essential for viral attachment/entry (Fig. 3), expressed on the surface of Cos7 cells mediates monocyte-derived DC recognition via a nucleic acid-independent and TLR-independent pathway, leading to the up-regulation of CD40, CD83, CD86 and HLA-DR and to the production of IFN-?

Gene_expression (production) of IFN in monocyte

10) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.72 Pain Relevance 0.10

The production of pro-inflammatory, cytotoxic cytokines interferon-y (IFN-y), tumor necrosis factor-alpha, (TNF-alpha), interleukin-2 (IL-2) is reduced.

Gene_expression (production) of IFN associated with necrosis, inflammation, cancer and cytokine

11) Confidence 0.75 Published 2006 Journal Med Arh Section Abstract Doc Link 16528935 Disease Relevance 0.75 Pain Relevance 0.21

We recently showed in CP local production of interferon (IFN)gamma, transforming growth factor (TGF)beta and death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), along with functional death receptor neoexpression and apoptosis in exocrine but not in endocrine cells.

Gene_expression (production) of IFN in endocrine cells associated with necrosis, cancer, apoptosis, chronic pancreatitis and death

12) Confidence 0.75 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127431 Disease Relevance 1.18 Pain Relevance 0.37

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Gene_expression (synthesis) of IFN-alpha associated with necrosis, anesthesia and cancer

13) Confidence 0.75 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.52

Peripheral blood mononuclear leukocytes were examined for IFN production induced by the IFN-alpha inducers Sendai virus and Escherichia coli and by the IFN-gamma inducers Concanavalin A and Lens culinaris lectin.

Spec (examined) Gene_expression (production) of IFN in Lens

14) Confidence 0.74 Published 1985 Journal Acta Paediatr Scand Section Abstract Doc Link 3993368 Disease Relevance 0.44 Pain Relevance 0

Meclomen at nontoxic levels (10(-5) to 10(-8) mol/l) caused a 2-6 fold increase in interferon (IFN) production in lymphocytes induced by Sendai virus.

Gene_expression (production) of IFN in lymphocytes

15) Confidence 0.73 Published 1990 Journal Acta Virol. Section Abstract Doc Link 1975722 Disease Relevance 0.17 Pain Relevance 0.18

Meclomen at nontoxic levels (10(-5) to 10(-8) mol/l) caused a 2-6 fold increase in interferon (IFN) production in lymphocytes induced by Sendai virus.

Gene_expression (production) of interferon in lymphocytes

16) Confidence 0.73 Published 1990 Journal Acta Virol. Section Abstract Doc Link 1975722 Disease Relevance 0.17 Pain Relevance 0.18

Recent phase III data from the AVOREN trial have demonstrated that first-line bevacizumab plus IFN produces clinically important and statistically significant improvements in PFS and tumor response compared with IFN alone, irrespective of patient subgroups.

Gene_expression (produces) of IFN associated with cancer

17) Confidence 0.71 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.74 Pain Relevance 0

Both AVOREN and CALGB 90206 show that bevacizumab plus IFN produces significant clinical benefit as first-line therapy for patients with metastatic RCC.

Gene_expression (produces) of IFN associated with renal cancer

18) Confidence 0.71 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.48 Pain Relevance 0

[A case of hypothyroidism induced by interferon therapy for renal cell carcinoma].

Gene_expression (therapy) of interferon associated with renal cancer and thyroid disease

19) Confidence 0.67 Published 2001 Journal Nippon Hinyokika Gakkai Zasshi Section Title Doc Link 11517570 Disease Relevance 0.84 Pain Relevance 0.09

We have investigated the in vitro effects of the neurohormone beta-endorphin (b-end) on natural killer (NK) activity and interferon (IFN) production mediated by large granular lymphocytes (LGL).

Gene_expression (production) of interferon in LGL

20) Confidence 0.67 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2934481 Disease Relevance 0 Pain Relevance 0

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