INT8670

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 19.85
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Afp) extracellular space (Afp) extracellular region (Afp)
molecular_function (Afp) cytoplasm (Afp)
Anatomy Link Frequency
Plasma 1
liver 1
Cranial 1
cerebrospinal fluid 1
Afp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.78 Very High Very High Very High
pain flank 1 99.76 Very High Very High Very High
abdominal pain 10 99.58 Very High Very High Very High
vincristine 1 98.92 Very High Very High Very High
imagery 10 96.24 Very High Very High Very High
Pain 7 93.12 High High
headache 4 92.64 High High
antagonist 2 91.84 High High
methotrexate 2 86.56 High High
palliative 7 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 129 99.98 Very High Very High Very High
Metastasis 48 99.92 Very High Very High Very High
Flank Pain 1 99.76 Very High Very High Very High
Abdominal Pain 10 99.58 Very High Very High Very High
Disease 26 99.04 Very High Very High Very High
Liver Cancer 24 98.76 Very High Very High Very High
Toxicity 16 97.52 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 3 97.52 Very High Very High Very High
Malignant Neoplastic Disease 2 95.76 Very High Very High Very High
Cv Unclassified Under Development 12 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most (77.8%) of the TAE-treated cases showed decreased alpha-fetoprotein (AFP) levels after treatment, but 57.1% of them suffered another rise in AFP levels and subsequently died.
Negative_regulation (decreased) of AFP
1) Confidence 0.58 Published 1995 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 7548796 Disease Relevance 0.85 Pain Relevance 0
Most (77.8%) of the TAE-treated cases showed decreased alpha-fetoprotein (AFP) levels after treatment, but 57.1% of them suffered another rise in AFP levels and subsequently died.
Negative_regulation (decreased) of alpha-fetoprotein
2) Confidence 0.58 Published 1995 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 7548796 Disease Relevance 0.85 Pain Relevance 0
A marked reduction in tumor size associated with decreased AFP level occurred after treatment.
Negative_regulation (decreased) of AFP associated with cancer
3) Confidence 0.55 Published 2008 Journal Cardiovasc Intervent Radiol Section Abstract Doc Link 18560935 Disease Relevance 0.80 Pain Relevance 0
AFP levels decreased 99.0% to 29.0% from initial levels, with a mean decrease of 60.0%.
Negative_regulation (decreased) of AFP
4) Confidence 0.55 Published 2008 Journal Cardiovasc Intervent Radiol Section Abstract Doc Link 18560935 Disease Relevance 0.75 Pain Relevance 0
The serum AFP level was 100 ng/ml at 3 weeks after the total gastrectomy, but decreased to 16 ng/ml by the end of postoperative month 3.
Negative_regulation (decreased) of AFP
5) Confidence 0.43 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16113495 Disease Relevance 1.37 Pain Relevance 0.09
Cranial radiotherapy was given together with chemotherapy, which resulted in a decrease of AFP to the normal range.
Negative_regulation (decrease) of AFP in Cranial
6) Confidence 0.43 Published 1992 Journal Surg Neurol Section Abstract Doc Link 1377409 Disease Relevance 0.71 Pain Relevance 0.20
The serum AFP levels were decreased in 70% of patients.
Negative_regulation (decreased) of serum AFP
7) Confidence 0.42 Published 1988 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 2458071 Disease Relevance 0.35 Pain Relevance 0.08
More than a 50% reduction in serum alfa-fetoprotein level was noted in 66.6% patients.
Negative_regulation (reduction) of alfa-fetoprotein
8) Confidence 0.40 Published 1992 Journal Am. J. Clin. Oncol. Section Abstract Doc Link 1381143 Disease Relevance 0.33 Pain Relevance 0.14
The second TAE decreased the patient's serum AFP to 2,200 ng/ml, but the level remained in the abnormal range.
Negative_regulation (decreased) of AFP
9) Confidence 0.38 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16113495 Disease Relevance 1.23 Pain Relevance 0.08
Soon after surgery the elevated alphafetoprotein (AFP) levels in the serum and cerebrospinal fluid were observed to decrease to normal levels.
Negative_regulation (decrease) of AFP in cerebrospinal fluid
10) Confidence 0.37 Published 1992 Journal Surg Neurol Section Abstract Doc Link 1377409 Disease Relevance 0.79 Pain Relevance 0.23
In the 6 patients with elevated serum alpha-fetoprotein (AFP) levels, 4 had decreased AFP after treatment, and the 2 mortalities had steadily increased AFP.
Negative_regulation (decreased) of AFP
11) Confidence 0.35 Published 1990 Journal Hepatogastroenterology Section Abstract Doc Link 2174823 Disease Relevance 1.21 Pain Relevance 0.09
Serum AFP and PIVKA-II were also reduced, and right flank pain disappeared.
Negative_regulation (reduced) of Serum AFP associated with pain flank
12) Confidence 0.31 Published 1994 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 8291906 Disease Relevance 0.78 Pain Relevance 0.10
The level of AFP and PIVKA-II decreased to 13.2 ng/ml and to 26 AU/ml, respectively, in February 2002.
Negative_regulation (decreased) of AFP
13) Confidence 0.30 Published 2004 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 14750333 Disease Relevance 0.82 Pain Relevance 0.06
Following HDAC with NAC, AFP markedly decreased.
Negative_regulation (decreased) of AFP associated with paracetamol
14) Confidence 0.29 Published 2005 Journal Pediatr Blood Cancer Section Abstract Doc Link 15770640 Disease Relevance 0.34 Pain Relevance 0.66
The level of AFP and CEA was reduced in all PR and NC cases except one.
Neg (except) Negative_regulation (reduced) of AFP
15) Confidence 0.24 Published 1993 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 7690535 Disease Relevance 0.16 Pain Relevance 0.09
Plasma AFP and hCG were decreased with significant clinical improvement.
Negative_regulation (decreased) of Plasma AFP in Plasma
16) Confidence 0.24 Published 1987 Journal Endocrinol. Jpn. Section Abstract Doc Link 2440666 Disease Relevance 1.30 Pain Relevance 0.19
Thus, when TAE is followed by a 0.2 time decrease in AFP, it is necessary to pay more attention to the gastric lesions.
Negative_regulation (decrease) of AFP
17) Confidence 0.18 Published 1990 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 1691802 Disease Relevance 0.22 Pain Relevance 0.13
On the other hand, the cases which showed apparent effects of TAE including 0.2 time decrease of AFP had the more gastric lesions (P less than 0.05) (Table 2).
Negative_regulation (decrease) of AFP
18) Confidence 0.18 Published 1990 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 1691802 Disease Relevance 0.38 Pain Relevance 0.12
As expected, AFP and heparin levels were not reduced by the filter, but heparin was completely removed in the washing process.
Neg (not) Negative_regulation (reduced) of AFP
19) Confidence 0.15 Published 2008 Journal BJA: British Journal of Anaesthesia Section Body Doc Link PMC2447531 Disease Relevance 0.25 Pain Relevance 0.03
The levels of serum AFP and PIVKA-II decreased to 374 ng/ml from 59,300 and to 35 AU/ml from 25,700, respectively, after this therapy.
Negative_regulation (decreased) of AFP
20) Confidence 0.13 Published 2004 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 14750333 Disease Relevance 1.07 Pain Relevance 0.08

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