INT86700

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.92
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
arterioles 2
chromaffin cells 1
Cav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 3 99.68 Very High Very High Very High
Calcium channel 2 99.56 Very High Very High Very High
cOX1 2 97.40 Very High Very High Very High
Neurotransmitter 1 94.56 High High
anesthesia 2 87.04 High High
Opioid 1 83.04 Quite High
Potency 1 61.72 Quite High
antagonist 5 56.96 Quite High
Inflammation 1 36.16 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 11 95.96 Very High Very High Very High
Dyskinesias 5 91.20 High High
Channelopathies 16 88.20 High High
Hypertension 45 87.56 High High
Sprains And Strains 1 68.64 Quite High
Diabetes Mellitus 7 43.76 Quite Low
Increased Venous Pressure Under Development 14 42.64 Quite Low
Vasculitis 1 36.88 Quite Low
Cardiovascular Disease 9 5.00 Very Low Very Low Very Low
Shock 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This loss of connectivity is triggered by a dysregulation of intraspine Cav1.3 L-type Ca2+ channels.
Regulation (dysregulation) of Cav1
1) Confidence 0.54 Published 2009 Journal Biol. Psychiatry Section Abstract Doc Link 18947822 Disease Relevance 0.60 Pain Relevance 0
In separate rats from the same groups, we compared eNOS and caveolin-1 (CAV-1) protein abundance in pial arterioles (via immunofluorescence analyses).
Regulation (abundance) of caveolin-1 in arterioles
2) Confidence 0.44 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10694495 Disease Relevance 0 Pain Relevance 0.09
In separate rats from the same groups, we compared eNOS and caveolin-1 (CAV-1) protein abundance in pial arterioles (via immunofluorescence analyses).
Regulation (abundance) of CAV-1 in arterioles
3) Confidence 0.44 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10694495 Disease Relevance 0 Pain Relevance 0.09
Fitting with these vital roles, CaV1/2 channels are highly regulated through a variety of feedback mechanisms that inactivate channels in response to either intracellular Ca2+ elevations (e.g., Ca2+-dependent inactivation [CDI]) or voltage-dependent conformational changes (e.g., voltage-dependent inactivation [VDI]).
Regulation (regulated) of CaV1
4) Confidence 0.08 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.09 Pain Relevance 0
Finally, our new results about the end-stage effects of CDI, together with rapid advances concerning the early events underlying Ca2+/CaM modulation of CaV1/2 channels, set the stage for investigating the events that link these two realms.
Regulation (modulation) of CaV1
5) Confidence 0.07 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0
Recently, the attention has been focused on the modulation of L-channels (CaV 1), which represent the major Ca2+ current component in rat and human chromaffin cells.
Regulation (modulation) of CaV 1 in chromaffin cells
6) Confidence 0.07 Published 2004 Journal Mol. Neurobiol. Section Abstract Doc Link 15034224 Disease Relevance 0 Pain Relevance 0.13
A23187—calcium ionophore; AA—arachidonic acid; AC—adenylyl cyclase; ATP—adenosine triphosphate; cAMP—cyclic adenosine monophosphate; CaV—voltage-activated calcium channel; cGMP—cyclic guanosine monophosphate; COX1—cyclooxygenase 1; eNOS—endothelial nitric oxide synthase; GTP—guanosine triphosphate; IP—PGI2 receptor; M—muscarinic receptor; O2•?
Regulation (voltage) of CaV associated with adenocard, calcium channel and cox1
7) Confidence 0.02 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.23 Pain Relevance 0.31

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