INT86703

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.58
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
endothelial cells 2
colon 2
nerve 2
dorsal root ganglions 2
Cav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 9 99.76 Very High Very High Very High
Neuritis 16 99.68 Very High Very High Very High
Sciatic nerve 10 99.68 Very High Very High Very High
ischemia 12 92.36 High High
IPN 4 87.92 High High
anesthesia 1 60.72 Quite High
spastic colon 2 50.00 Quite Low
Calcium channel 2 50.00 Quite Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.76 Very High Very High Very High
Experimental Autoimmune Neuritis 16 99.68 Very High Very High Very High
Ganglion Cysts 1 99.20 Very High Very High Very High
Apoptosis 2 93.04 High High
Cv Unclassified Under Development 10 92.36 High High
Coronary Artery Disease 2 87.16 High High
Injury 2 85.48 High High
Immunization 2 84.28 Quite High
Inflammatory Pain 2 78.80 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The result of this experiment shows that there was a twofold increase in caveolin-1 gene expression in rat dorsal root ganglions 24 h after Complete Freund's Adjuvant administration and a decrease at 48 h.
Positive_regulation (increase) of Gene_expression (expression) of caveolin-1 gene in dorsal root ganglions associated with ganglion cysts
1) Confidence 0.70 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20300998 Disease Relevance 0.25 Pain Relevance 0.15
In the present study we demonstrated involvement of ROS in IP-mediated GLUT-4 translocation along with increased expression of caveolin (Cav)-3, phospho (p)-endothelial nitric oxide synthase (eNOS), p-Akt, and decreased expression of Cav-1.
Positive_regulation (increased) of Gene_expression (expression) of Cav
2) Confidence 0.52 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.51 Pain Relevance 0.30
Consequently, we postulated that caveolin-1 expression increased in the sciatic nerves with EAN; this possibly mediated either molecular trafficking or nitric oxide generation partly through the activation of eNOS in vascular endothelial cells, as well as in inflammatory macrophages in EAN and/or cellular apoptosis of inflammatory cells.
Positive_regulation (increased) of Gene_expression (expression) of caveolin-1 in endothelial cells associated with inflammation, sciatic nerve, apoptosis and neuritis
3) Confidence 0.49 Published 2006 Journal Brain Res. Section Abstract Doc Link 16806125 Disease Relevance 1.13 Pain Relevance 0.98
The immunohistochemical scores of Cav1.2 and Cav1.3 expression increased in colon of D-IBS model rats as compared with those in normal control rats (3.43 +/- 0.92 vs 2.82 +/- 0.60, P = 0.034, 4.32 +/- 0.51 vs 3.75 +/- 1.05, P = 0.039).
Positive_regulation (increased) of Gene_expression (expression) of Cav1 in colon
4) Confidence 0.47 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137275 Disease Relevance 0.12 Pain Relevance 0
The inflammatory cells with intense p-caveolin-1 expression in the EAN-affected individual nerve fascicles were not positive for terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL), while the TUNEL-positive apoptotic cells in the perineurium, where infiltration initially occurred, were weakly positive for p-caveolin-1.
Positive_regulation (intense) of Gene_expression (expression) of p-caveolin-1 in nerve associated with inflammation, apoptosis and neuritis
5) Confidence 0.44 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 1.08 Pain Relevance 0.97
Pial arteriolar CAV-1 expression was higher in OVX versus intact and E(2)-treated OVX females.
Positive_regulation (higher) of Gene_expression (expression) of CAV-1
6) Confidence 0.40 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10694495 Disease Relevance 0 Pain Relevance 0.06
IP increased expression of GLUT-4, Cav-3, and p-AKT and p-eNOS compared with I/R.
Positive_regulation (increased) of Gene_expression (expression) of Cav
7) Confidence 0.38 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.43 Pain Relevance 0.27

General Comments

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