INT86713

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.44
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mip) plasma membrane (Mip) transmembrane transport (Mip)
Anatomy Link Frequency
blood 1
muscle cells 1
macrophage 1
Mip (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 163 100.00 Very High Very High Very High
Inflammation 141 100.00 Very High Very High Very High
Central nervous system 28 100.00 Very High Very High Very High
chemokine 198 97.36 Very High Very High Very High
Inflammatory response 17 87.20 High High
Inflammatory stimuli 12 67.76 Quite High
cva 3 60.64 Quite High
substance P 1 58.96 Quite High
antagonist 2 58.00 Quite High
Hippocampus 8 28.32 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 179 100.00 Very High Very High Very High
Cancer 7 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Sepsis 130 99.98 Very High Very High Very High
Disease 157 99.72 Very High Very High Very High
Sprains And Strains 51 99.64 Very High Very High Very High
Encephalopathy 9 99.18 Very High Very High Very High
Myositis 5 97.52 Very High Very High Very High
Frailty 15 97.36 Very High Very High Very High
Brain Injury 4 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, we did not detect an upregulation of MIP-1?
Positive_regulation (upregulation) of MIP
1) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.62 Pain Relevance 0.23
Increased MIP-1?
Positive_regulation (Increased) of MIP
2) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0 Pain Relevance 0.09
Both sepsis models triggered a marked upregulation of RANTES and MIP-1?
Positive_regulation (upregulation) of MIP associated with sepsis
3) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.82 Pain Relevance 0.17
Interestingly, we did not observe any upregulation of either MIP-1?
Positive_regulation (upregulation) of MIP
4) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.44 Pain Relevance 0.22
within muscle cells following exposure to LPS in vitro, suggesting that sepsis-induced MIP-1?
Positive_regulation (induced) of MIP in muscle cells associated with sepsis
5) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.62 Pain Relevance 0.25
Also, chemokine profiles in the acute phase were different, with high levels of RANTES found in mice infected either both strains, but with higher levels of cardiac MIG, MCP-1, and MIP-1?
Positive_regulation (levels) of MIP associated with chemokine and sprains and strains
6) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.72 Pain Relevance 0.21
A further recent study found that PD patients had elevated basal and LPS-induced blood levels of numerous proinflammatory cytokines, including MCP-1, RANTES, MIP-1?
Positive_regulation (elevated) of MIP in blood associated with disease and cytokine
7) Confidence 0.45 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.85 Pain Relevance 0.50
In this regard, we have recently reported a marked upregulation of CCR1 and two of its major ligands, RANTES (CCL5) and MIP-1?
Positive_regulation (upregulation) of MIP
8) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.91 Pain Relevance 0.40
Exposure to whole DEP + OVA showed a further significant increase in MIP-1?
Positive_regulation (increase) of MIP
9) Confidence 0.45 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.19 Pain Relevance 0.13
Following the development of the PTRE in this model a number of cytokines are increased within the CNS including tumour necrosis factor (TNF) alpha, interleukins 1, 4 and 6, and macrophage inflammatory protein (MIP)-1.
Positive_regulation (increased) of MIP in macrophage associated with necrosis, inflammation, cancer, encephalopathy, central nervous system and cytokine
10) Confidence 0.35 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10695713 Disease Relevance 1.27 Pain Relevance 0.43

General Comments

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