INT86717

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 8.88
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 4
macrophages 2
cerebellar granule cells 2
spinal cord segments 2
pia mater 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 13 99.98 Very High Very High Very High
Neuronal nitric oxide synthase 4 99.90 Very High Very High Very High
Inflammatory stimuli 6 99.56 Very High Very High Very High
cytokine 57 99.34 Very High Very High Very High
agonist 4 98.40 Very High Very High Very High
Spinal cord 2 97.76 Very High Very High Very High
dorsal root ganglion 3 96.68 Very High Very High Very High
Inflammation 96 96.36 Very High Very High Very High
Hippocampus 55 95.92 Very High Very High Very High
nMDA receptor 64 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 194 100.00 Very High Very High Very High
Death 26 99.92 Very High Very High Very High
Apoptosis 19 99.70 Very High Very High Very High
Sepsis 41 99.68 Very High Very High Very High
INFLAMMATION 126 99.56 Very High Very High Very High
Lung Injury 1 99.40 Very High Very High Very High
Pneumonia 3 96.76 Very High Very High Very High
Ganglion Cysts 3 96.68 Very High Very High Very High
Toxicity 29 96.48 Very High Very High Very High
Necrosis 18 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This strongly suggests that KCZ is able to reverse the increase in NOS activity evoked by stress-restress and, furthermore, also posits a possible dual mode of action for KCZ in preventing trauma-related sequelae in PTSD by suppressing the immediate release of glucocorticoids, blocking hypersensitive glucocorticoid receptors and/or preventing any subsequent NO-driven neuronal events.
Negative_regulation (reverse) of Positive_regulation (increase) of NOS in neuronal associated with stress, post-traumatic stress disorder and injury
1) Confidence 0.30 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.58 Pain Relevance 0.06
Indeed, activation of NOS by TDS stress is selectively blocked by the selective iNOS inhibitor, aminoguanidine and not the selective nNOS inhibitor, 7-nitroindazole (Harvey et al 2004).
Negative_regulation (blocked) of Positive_regulation (activation) of NOS associated with stress
2) Confidence 0.30 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.92 Pain Relevance 0.29
Inducible nitric oxide synthase and tumor necrosis factor expression were reduced after ischemic preconditioning in patients with unstable angina.
Negative_regulation (reduced) of Positive_regulation (Inducible) of nitric oxide synthase
3) Confidence 0.27 Published 2008 Journal Eur J Cardiothorac Surg Section Body Doc Link 18842422 Disease Relevance 0 Pain Relevance 0
Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells.
Negative_regulation (inhibit) of Positive_regulation (inducible) of nitric oxide synthase in respiratory
4) Confidence 0.24 Published 2009 Journal Nitric Oxide Section Title Doc Link 18976718 Disease Relevance 0.36 Pain Relevance 0.13
In addition to activity at these receptors, agmatine irreversibly inhibits neuronal nitric oxide synthase and downregulates inducible nitric oxide synthase.
Negative_regulation (downregulates) of Positive_regulation (inducible) of nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
5) Confidence 0.22 Published 2007 Journal CNS Drugs Section Abstract Doc Link 17927294 Disease Relevance 0.46 Pain Relevance 0.46
L-NIL (30 mg/kg), a selective inducible NOS (iNOS) inhibitor had no effects on either flow or conductance.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of NOS
6) Confidence 0.20 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729360 Disease Relevance 0.07 Pain Relevance 0
Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress.
Neg (unaffected) Negative_regulation (unaffected) of Positive_regulation (Inducible) of NOS in pia mater associated with stress
7) Confidence 0.18 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.94 Pain Relevance 0.52
The gap-junction blocker tonabersat, an inducible nitric oxide synthase (NOS) inhibitor and botulinum toxin A are all being investigated in clinical trials as preventive therapies.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of nitric oxide synthase
8) Confidence 0.14 Published 2007 Journal Nature clinical practice. Neurology Section Abstract Doc Link 17982431 Disease Relevance 0.47 Pain Relevance 0.41
Specific inhibition of inducible NOS during sepsis may represent a potential therapeutic strategy [52-55], although dose selection will be critical.
Negative_regulation (inhibition) of Positive_regulation (inducible) of NOS associated with sepsis
9) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1751057 Disease Relevance 0.40 Pain Relevance 0.04
M), the non-selective NOS inhibitor L-NAME (100 ?
Negative_regulation (inhibitor) of Positive_regulation (selective) of NOS
10) Confidence 0.09 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.46 Pain Relevance 0.09
It scavenges most of the oxygen- and nitrogen-based reactants, inhibits inducible nitric oxide synthase, repairs DNA damage and restores cellular energy depletion.
Negative_regulation (inhibits) of Positive_regulation (inducible) of nitric oxide synthase
11) Confidence 0.07 Published 2008 Journal Interdisciplinary Toxicology Section Abstract Doc Link PMC2993477 Disease Relevance 0.57 Pain Relevance 0
Anthocyanins were shown to be effective inhibitors of lipid peroxidation, the production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) activity in different model systems [22-24].
Negative_regulation (inhibitors) of Positive_regulation (inducible) of nitric oxide synthase
12) Confidence 0.06 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2438359 Disease Relevance 0.05 Pain Relevance 0.14
Resuscitation with this combination has been shown to prevent lung injury and bacterial translocation, downregulate inducible nitric oxide synthase, and decrease end-organ damage [93-95].
Negative_regulation (downregulate) of Positive_regulation (inducible) of nitric oxide synthase in lung associated with lung injury
13) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 0.67 Pain Relevance 0
Real-time reverse transcription-polymerase chain reaction showed that NC reduced the up-regulation of inducible nitric oxide synthase mRNA but not that of neuronal nitric oxide synthase mRNA in spinal cord segments after CFA.
Negative_regulation (reduced) of Positive_regulation (up-regulation) of nitric oxide synthase mRNA in spinal cord segments associated with orphanin, spinal cord and neuronal nitric oxide synthase
14) Confidence 0.02 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17387690 Disease Relevance 1.07 Pain Relevance 1.75
Agmatine also inhibits the release of norepinephrine from presynaptic terminals (Molderings et al., 2002) and can inhibit the induction of inducible NOS (iNOS) by inflammatory stimuli (Auguet et al., 1995; Regunathan & Piletz, 2003).
Negative_regulation (inhibit) of Positive_regulation (induction) of NOS associated with inflammatory stimuli
15) Confidence 0.02 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0.70 Pain Relevance 0.45
Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase.
Negative_regulation (inhibition) of Positive_regulation (inducible) of nitric oxide synthase in cerebellar granule cells associated with agonist, apoptosis, death and cytokine
16) Confidence 0.01 Published 1999 Journal J. Neuroimmunol. Section Title Doc Link 10695726 Disease Relevance 0.90 Pain Relevance 0.53
Inhibitory effects of these drugs on lipopolysaccharide (LPS)-induction of inducible nitric oxide synthase (iNOS) and LPS-stimulated translocation of NficB were determined by use of RAW 264.7 murine macrophages.
Negative_regulation (effects) of Positive_regulation (induction) of nitric oxide synthase in macrophages
17) Confidence 0.01 Published 2003 Journal Am. J. Vet. Res. Section Body Doc Link 12602591 Disease Relevance 0 Pain Relevance 0
, and inducible nitric oxide synthase (iNOS) are attenuated by the addition of the NADPH oxidase inhibitor diphenyleneiodonium (DPI) [63].
Negative_regulation (attenuated) of Positive_regulation (inducible) of nitric oxide synthase
18) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604892 Disease Relevance 0.26 Pain Relevance 0.33

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