INT86728

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 3 96.66 Very High Very High Very High
agonist 1 91.88 High High
opioid receptor 5 91.56 High High
Enkephalin 1 90.28 High High
narcan 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of mu-opioid receptors to develop homologous desensitization was greatly impaired following the transfection of a cDNA fragment encoding the GRK2(495-689) polypeptide, which is believed to block Gbetagamma-mediated transduction events including the membrane translocation and activation of GRK2.
Negative_regulation (block) of Positive_regulation (activation) of GRK2 associated with mu opioid receptor
1) Confidence 0.38 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698001 Disease Relevance 0 Pain Relevance 0.45

General Comments

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