INT86751

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 62
Total Number 63
Disease Relevance 40.10
Pain Relevance 20.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
T cells 8
macrophages 2
plasma 1
liver 1
cleavage 1
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1273 100.00 Very High Very High Very High
cytokine 1040 100.00 Very High Very High Very High
Morphine 42 99.82 Very High Very High Very High
dexamethasone 19 99.72 Very High Very High Very High
Clonidine 1 99.44 Very High Very High Very High
Paracetamol 50 99.34 Very High Very High Very High
anesthesia 28 99.12 Very High Very High Very High
agonist 50 99.04 Very High Very High Very High
Inflammatory response 116 98.94 Very High Very High Very High
antagonist 66 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1409 100.00 Very High Very High Very High
Disease 386 100.00 Very High Very High Very High
Cancer 317 100.00 Very High Very High Very High
Asthma 75 100.00 Very High Very High Very High
Colitis 44 100.00 Very High Very High Very High
Disease Progression 12 100.00 Very High Very High Very High
Hyperalgesia 73 99.98 Very High Very High Very High
Targeted Disruption 313 99.96 Very High Very High Very High
Salivary Gland Disease 14 99.92 Very High Very High Very High
Injury 521 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the alpha2-agonists UK-14304, clonidine and xylazine significantly decreased the IL-10 plasma level, whereas the alpha2-antagonists CH-38083, prazosine and WB-4101 increased it.
Negative_regulation (decreased) of IL-10 in plasma associated with antagonist, agonist and clonidine
1) Confidence 0.59 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.29
However, the serum IL-10 level was highest in GF mice among three groups, and LPS administered in drinking water to GF mice caused a decrease in the IL-10 level.
Negative_regulation (decrease) of IL-10
2) Confidence 0.57 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.08 Pain Relevance 0.08
The pretreatment with naltrexone at doses up to 20 mg/kg did not prevent the decrease of IL-10 and IL-12 induced by morphine.
Negative_regulation (decrease) of IL-10 associated with morphine
3) Confidence 0.56 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.98
In contrast, morphine-induced inhibition of IL-10 disappeared between 10 and 12 days of treatment, in parallel with tolerance to the antinociceptive effect.
Negative_regulation (inhibition) of IL-10 associated with tolerance, antinociceptive and morphine
4) Confidence 0.56 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 1.11
One hour after the acute administration of 5, 10, and 20 mg/kg of morphine a dose-related decrease of both IL-10 and IL-12 levels was present.
Negative_regulation (decrease) of IL-10 associated with morphine
5) Confidence 0.56 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.88
In contrast, morphine-induced inhibition of IL-10 disappeared between 10 and 12 days of treatment, in parallel with tolerance to the antinociceptive effect.
Negative_regulation (inhibition) of IL-10 associated with tolerance, antinociceptive and morphine
6) Confidence 0.56 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 1.01
The pretreatment with naltrexone at doses up to 20 mg/Kg did not prevent the decrease of IL-10 and IL-12 induced by morphine.
Negative_regulation (decrease) of IL-10 associated with morphine
7) Confidence 0.56 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 0.95
One hour after the acute administration of 5, 10, and 20 mg/Kg morphine, a dose-related decrease of IL-10 and IL-12 levels was present.
Negative_regulation (decrease) of IL-10 associated with morphine
8) Confidence 0.56 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 0.88
We observed a significant decrease in serum IL-10 in mice infected with an M2-null MHV68 mutant.
Negative_regulation (decrease) of IL-10
9) Confidence 0.50 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.17 Pain Relevance 0.03
, but also decreases IL-10.
Negative_regulation (decreases) of IL-10
10) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 1.17 Pain Relevance 0.53
Further, a recent study suggests that IL-10 blockade facilitates DNA-vaccine induced T cell response in an LCMV mouse model [48].
Negative_regulation (blockade) of IL-10 in T cell
11) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 1.24 Pain Relevance 0
We found that CD4+ T cells produce a significant amount of IL-10 and may be a major cellular source of IL-10 in vivo during WNV infection.
Negative_regulation (source) of IL-10 in T cells associated with infection
12) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.44 Pain Relevance 0
Human IL-10 could complement the loss of vIL-10 during EBV infection of B cells, demonstrating that it is IL-10 mediated signaling that augments B cell transformation following EBV infection [50].
Negative_regulation (loss) of vIL-10 in B cells associated with epstein-barr virus and infection
13) Confidence 0.42 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 1.00 Pain Relevance 0
Blockade of the IL-10R resulted in a significant decrease in the titer of MCMV in the salivary glands with a concurrent increase in the frequency of IFN?
Negative_regulation (Blockade) of IL-10R in salivary glands associated with salivary gland disease and cytomegalovirus infection
14) Confidence 0.42 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 1.37 Pain Relevance 0
In this regard, mice lacking both IL-10 and iNOS genes were protected from APAP-induced liver injury and lethality when compared with IL-10 KO mice.
Negative_regulation (lacking) of IL-10 in liver associated with targeted disruption, paracetamol and injury
15) Confidence 0.41 Published 2002 Journal Hepatology Section Abstract Doc Link 11826401 Disease Relevance 1.75 Pain Relevance 1.01
Consistent down-regulation of critical inflammatory genes in ETS- and doubly OVA-exposed mice was confirmed through qRT-PCR, revealing down-regulation of 17 asthma-related and/or inflammatory genes (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2, Il4, Il6, Il10, Il13, Il1b, Tnfa).
Negative_regulation (regulation) of Il10 associated with asthma, nicotine addiction and inflammation
16) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.16 Pain Relevance 0.52
Interestingly, IL-10 mRNA decreased significantly in knockout mice 3 weeks after bleomycin (Figure 5D).
Negative_regulation (decreased) of IL-10 associated with targeted disruption
17) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.48 Pain Relevance 0.31
This effect is mediated by the absence of proteolytic cleavage and subsequent inactivation of endogenous IL-10.
Negative_regulation (inactivation) of IL-10 in cleavage
18) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.46 Pain Relevance 0.23
Disease progression in VMD2-IL-10 transgenic mice appears to develop in two stages.
Negative_regulation (progression) of VMD2-IL-10 associated with targeted disruption and disease progression
19) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.05 Pain Relevance 0.27
As expected, treatment with methotrexate stimulated IL-10 accumulation in the exudate by 56% in wild-type mice, but significantly decreased IL-10 levels in exudates of A2A-deficient mice.
Negative_regulation (decreased) of IL-10 associated with methotrexate
20) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 0.85 Pain Relevance 0.70

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