INT86771

Context Info Confidence 0.38 First Reported 2000 Last Reported 2006 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 4.55 Pain Relevance 0.29

cytosol (TAOK1) kinase activity (TAOK1) cytoplasm (TAOK1)

TAOK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 3 95.12 cva 3 90.88 anesthesia 2 78.08 ischemia 3 72.60 cytokine 4 49.44 Inflammation 14 49.04 Botox 4 5.00

Disease Link Frequency Relevance Heat Thromboangitis Obliterans 13 100.00 Disease 18 99.34 Thyroid Disease 72 98.86 Graves' Ophthalmopathy 46 98.52 Optic Disorders 6 95.48 Pain 3 95.12 Cv Unclassified Under Development 4 93.52 Diplopia 18 91.84 Cv General 3 Under Development 3 90.88 Cataract 12 89.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The prevalence of TAO in southwest Poland is 8.1/100,000 and the incidence of the disease steadily declines; there was no increase of TAO in women.

Neg (no) Positive_regulation (increase) of TAO associated with thromboangitis obliterans and disease

1) Confidence 0.38 Published 2000 Journal Angiology Section Abstract Doc Link 10701722 Disease Relevance 2.41 Pain Relevance 0.22

A single case report of TAO in a previously stable Graves' hyperthyroidism patient27 postulates a local pressure mechanism for the induction of TAO, and extrapolates this to suggest that local factors are the main determinant of the extrathyroidal manifestations of dysthyroid states.

Positive_regulation (induction) of TAO associated with thyroid disease and graves' ophthalmopathy

2) Confidence 0.01 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908832 Disease Relevance 1.19 Pain Relevance 0.08

Two patients underwent orbital decompression for cosmesis after stabilization of the TAO.

Positive_regulation (stabilization) of TAO

3) Confidence 0.01 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908832 Disease Relevance 0.95 Pain Relevance 0

General Comments

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