INT86772

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 20
Disease Relevance 1.93
Pain Relevance 6.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 5
lateral globus pallidus 2
neuronal 1
neurons 1
brain 1
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 593 100.00 Very High Very High Very High
Glutamate 84 100.00 Very High Very High Very High
dopamine receptor 33 100.00 Very High Very High Very High
Substantia nigra 40 99.56 Very High Very High Very High
Hippocampus 15 99.46 Very High Very High Very High
adenocard 16 99.42 Very High Very High Very High
Nucleus accumbens 90 99.24 Very High Very High Very High
midbrain 52 99.14 Very High Very High Very High
Serotonin 30 99.04 Very High Very High Very High
Dynorphin 33 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Akathisia 1 99.54 Very High Very High Very High
Dystonia 1 98.86 Very High Very High Very High
Opiate Addiction 2 97.00 Very High Very High Very High
Targeted Disruption 182 96.08 Very High Very High Very High
Sprains And Strains 66 95.16 Very High Very High Very High
Recurrence 2 94.76 High High
Shock 2 91.48 High High
Disease 55 91.36 High High
Attention Deficit Hyperactivity Disorder 163 81.32 Quite High
Parkinson's Disease 2 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Independently of the studies on the proportion of co-localization of D1R and D2R, several lines of evidence indicate that both receptors can interact in the same cells.
Localization (localization) of D2R
1) Confidence 0.80 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.14
The first evidence came from some ISH studies in which co-localization of D1R and D2R mRNAs was found in 27–47% of all striatal MSNs (Meador-Woodruff et al., 1991; Weiner et al., 1991; Lester et al., 1993).
Localization (localization) of D2R
2) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0
Within the striatum, the postsynaptic effects of dopamine (DA) are mediated mainly by stimulation of D1 and D2 types of DA receptors (D1R and D2R) (Kebabian and Calne, 1979; Stoof and Kebabian, 1984) localized in MSNs (Hersch et al., 1995; Yung et al., 1995).
Localization (localized) of D2R in striatum associated with dopamine
3) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.43
The degree of D1R and D2R co-localization in the striatum has been a matter of intense debate.
Localization (localization) of D2R in striatum
4) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0
These results are in agreement with the anatomical observations reporting that the proportion of co-localization between D1R and D2R was higher in the NAc than in the dorsal striatum (Bertran-Gonzalez et al., 2008; Hasbi et al., 2009).
Localization (localization) of D2R in striatum associated with nucleus accumbens
5) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.05 Pain Relevance 0.20
Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors are colocalized in striatal medium spiny neurons.
Localization (colocalized) of D2R in neurons associated with dopamine and adenocard
6) Confidence 0.74 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908627 Disease Relevance 0.37 Pain Relevance 0.38
CONCLUSIONS: Imaging of D2R availability and endogenous dopamine release in mice is feasible using [(123)I]IBZM single pinhole SPECT.
Localization (release) of D2R
7) Confidence 0.71 Published 2008 Journal Eur. J. Nucl. Med. Mol. Imaging Section Body Doc Link 18425511 Disease Relevance 0 Pain Relevance 0
It is important to underline that the proportion of D1R and D2R co-localization appears much higher in cultured striatal neurons (between 60 and 100%) than in the adult striatum (Wong et al., 1999; Aizman et al., 2000; Lee et al., 2004; Hasbi et al., 2009).
Localization (localization) of D2R in striatum
8) Confidence 0.70 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0
Conversely, mRNAs encoding DRD2 are selectively localized in neurons projecting to the lateral globus pallidus (indirect pathway) and colocalize with enkephalin.
Localization (localized) of DRD2 in lateral globus pallidus associated with enkephalin
9) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.35
Conversely, mRNAs encoding DRD2 are selectively localized in neurons projecting to the lateral globus pallidus (indirect pathway) and colocalize with enkephalin.
Localization (localized) of DRD2 in lateral globus pallidus associated with enkephalin
10) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.35
Furthermore, given the effects of M2, M4, M5 muscarinic receptors and the D2 dopamine receptor in dopamine release [23]–[25], [66], and their varied and wide distribution in the brain [28], [29], we postulate that, these receptors are more likely to contribute to the regulation of emotion and motivation.
Localization (release) of D2 dopamine receptor in brain associated with dopamine and dopamine receptor
11) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.37 Pain Relevance 0.13
Fresh brain tissue from the hippocampus and prefrontal cortex was dissected from B6 and D2, snap-frozen in liquid nitrogen, and stored at ?
Localization (dissected) of D2 in cortex associated with hippocampus
12) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.34 Pain Relevance 0.12
The consequences of increased extracellular dopamine is demonstrated in the DAT-KO mouse which loses the normal inhibitory effect of DRD2 on dopamine neuron firing rate in the VTA and substantia nigra, as well as dopamine release-regulating DRD2 function in the striatum [190].
Localization (release) of DRD2 in striatum associated with dopamine, substantia nigra and midbrain
13) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.25 Pain Relevance 1.00
In addition to their ability to interact with several other G protein-coupled receptors, including CB1, A2a, and D3 receptors (see Franco et al., 2008), D1R and D2R can interact with each other and can be found in the same protein complexes as demonstrated by co-immunoprecipitation from rat striatal extracts (Lee et al., 2004).
Localization (found) of D2R
14) Confidence 0.33 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.12
Our results demonstrated that DA release and subsequent DA D1 and D2 receptor activation is essential for the development of sensitization to the rewarding effects of morphine.
Localization (release) of D2 receptor associated with dopamine and morphine
15) Confidence 0.31 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671878 Disease Relevance 0 Pain Relevance 0.90
Extrapyramidal symptoms (EPSs) (dystonic reaction, rigidity, and akathisia) occur as a result of D2 receptor blockade.
Localization (blockade) of D2 receptor associated with akathisia and dystonia
16) Confidence 0.28 Published 2007 Journal Psychopharmacol Bull Section Abstract Doc Link 17514191 Disease Relevance 0.20 Pain Relevance 0.14
Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males.
Localization (release) of dopamine D2 receptor associated with dopamine and opiate
17) Confidence 0.17 Published 2008 Journal Eur Neuropsychopharmacol Section Title Doc Link 18077142 Disease Relevance 0.19 Pain Relevance 0.87
This finding implies that D2 receptor-expressing MSSNs are subjected to increased glutamate release at the synapse.
Localization (release) of D2 receptor-expressing in synapse associated with glutamate
18) Confidence 0.15 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.06 Pain Relevance 0.16
Dysregulation of glutamate release is compounded by loss of DA D2, CB1, mGluR2/3 and other presynaptic receptors regulating glutamate release at corticostriatal terminals.
Localization (release) of D2 associated with glutamate
19) Confidence 0.06 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.09 Pain Relevance 0.44
These results demonstrate that the striatal organizational pattern of D1 and D2 receptor segregation in distinct neuronal populations described in rodent also exists in primate.
Localization (segregation) of D2 receptor in neuronal
20) Confidence 0.05 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10701753 Disease Relevance 0 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox