INT86780

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 145
Total Number 175
Disease Relevance 117.09
Pain Relevance 31.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
blood 8
liver 8
brain 6
plasma 5
hypothalamus 4
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 7 100.00 Very High Very High Very High
Hippocampus 132 99.96 Very High Very High Very High
fibrosis 1176 99.92 Very High Very High Very High
cINOD 118 99.92 Very High Very High Very High
Calcitonin gene-related peptide 20 99.90 Very High Very High Very High
cytokine 542 99.82 Very High Very High Very High
Inflammation 1432 99.70 Very High Very High Very High
agonist 86 99.70 Very High Very High Very High
qutenza 12 99.42 Very High Very High Very High
ischemia 145 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1045 100.00 Very High Very High Very High
Ureteral Obstruction 1170 99.98 Very High Very High Very High
Fibrosis 1436 99.92 Very High Very High Very High
Chronic Renal Failure 199 99.92 Very High Very High Very High
Death 86 99.92 Very High Very High Very High
Diabetes Mellitus 2768 99.84 Very High Very High Very High
Sepsis 164 99.84 Very High Very High Very High
Shock 45 99.80 Very High Very High Very High
Hypertension 1578 99.76 Very High Very High Very High
Toxicity 59 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current study aimed to examine whether induction of HO-1 and its by-products modulated endothelial interaction with circulating leukocytes and platelets evoked by sevoflurane anesthesia in vivo.
Spec (whether) Positive_regulation (induction) of HO-1 in platelets associated with anesthesia
1) Confidence 0.70 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11465558 Disease Relevance 0 Pain Relevance 0.17
During sevoflurane anesthesia, however, nitric oxide suppression by L-NAME deteriorated microvascular flows irrespective of the presence or absence of the HO-1 induction.
Positive_regulation (induction) of HO-1
2) Confidence 0.70 Published 2001 Journal Anesthesiology Section Body Doc Link 11465558 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Heme oxygenase 1 (HO-1), induced by a variety of stressors, provides endogenous carbon monoxide (CO) and bilirubin, both of which play consequential roles in organs.
Positive_regulation (induced) of HO-1
3) Confidence 0.70 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11465558 Disease Relevance 0 Pain Relevance 0.15
Following hemin treatment, we observed a time-dependent increase in HO-1 protein in the liver and in serum bilirubin levels.
Positive_regulation (increase) of HO-1 protein in liver
4) Confidence 0.69 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12051994 Disease Relevance 0.37 Pain Relevance 0.68
Treatment of rats with a hepatotoxic dose of acetaminophen (1 g/kg, ip) resulted in a time-dependent induction of HO-1 in the liver.
Positive_regulation (induction) of HO-1 in liver associated with paracetamol
5) Confidence 0.69 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12051994 Disease Relevance 0.35 Pain Relevance 0.53
Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin.
Positive_regulation (induction) of heme oxygenase-1 in macrophages associated with paracetamol and hepatotoxicity
6) Confidence 0.69 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 12051994 Disease Relevance 0.42 Pain Relevance 0.53
In rats, orally administered indomethacin up-regulated HO-1, induced apoptosis, and produced lesions at gastric mucosa.
Positive_regulation (up-regulated) of HO-1 associated with apoptosis
7) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16945925 Disease Relevance 0.57 Pain Relevance 1.09
Indomethacin activated the HO-1 promoter and caused nuclear accumulation of NF-E2-related factor 2 (Nrf2), a transcription factor for the HO-1 gene.
Positive_regulation (activated) of HO-1 promoter
8) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16945925 Disease Relevance 0.54 Pain Relevance 1.19
An inhibitor of HO-stimulated NSAID-induced apoptosis in vitro and in vivo and also stimulated NSAID-produced gastric lesions, suggesting that NSAID-induced up-regulation of HO-1 protects the gastric mucosa from NSAID-induced gastric lesions by inhibiting NSAID-induced apoptosis.
Positive_regulation (up-regulation) of HO-1 associated with cinod and apoptosis
9) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16945925 Disease Relevance 0.57 Pain Relevance 1.23
Heme oxygenase-1 (HO-1) is up-regulated by various stressors and protects cells against stressors.
Positive_regulation (up-regulated) of HO-1
10) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16945925 Disease Relevance 0.49 Pain Relevance 0.88
Heme oxygenase-1 (HO-1) is up-regulated by various stressors and protects cells against stressors.
Positive_regulation (up-regulated) of Heme oxygenase-1
11) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16945925 Disease Relevance 0.49 Pain Relevance 0.89
Here, we have examined up-regulation of HO-1 by NSAIDs and the contribution of HO-1 to the protection of gastric mucosal cells against NSAIDs both in vitro and in vivo.
Spec (examined) Positive_regulation (up-regulation) of HO-1 associated with cinod
12) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16945925 Disease Relevance 0.54 Pain Relevance 1.03
Tissue specimens were taken to determine HO-1/HSP32, 72, and 90 induction by Western blot analysis.
Positive_regulation (induction) of HO-1
13) Confidence 0.69 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 1.00 Pain Relevance 0.23
Other research shows that increased HO-1 activity in lung epithelial cells protects cells against hyperoxic injury.
Positive_regulation (increased) of HO in epithelial cells associated with injury
14) Confidence 0.68 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 1.35 Pain Relevance 0
Mechanical stress has been shown to cause oxidant stress [10] and Hmox-1 levels are increased when cells are exposed to oxidative stress [11].
Positive_regulation (increased) of Hmox-1 associated with stress
15) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2258306 Disease Relevance 0.88 Pain Relevance 0.04
Nitric oxide isn't the only mediator of Hmox-1 upregulation.
Positive_regulation (upregulation) of Hmox-1
16) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2258306 Disease Relevance 0.77 Pain Relevance 0.03
Thus, if Hmox-1 is upregulated independently of NO (as may be happening at the later time points), then NO is strongly inhibited.
Neg (independently) Positive_regulation (upregulated) of Hmox-1
17) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2258306 Disease Relevance 0.76 Pain Relevance 0.05
For example, hemin can upregulate Hmox-1 (independently of NO).
Positive_regulation (upregulate) of Hmox-1
18) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2258306 Disease Relevance 0.80 Pain Relevance 0.05
Upregulation of HO-1 has hepatoprotective effects, whereas iNOS has injurious effects to the liver.
Positive_regulation (Upregulation) of HO-1 in liver
19) Confidence 0.67 Published 2005 Journal J Trauma Section Abstract Doc Link 15824646 Disease Relevance 0.72 Pain Relevance 0.35
The oxidative stress proteins inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) are upregulated in the liver during sepsis but have opposite roles.
Positive_regulation (upregulated) of HO-1 in liver associated with stress and sepsis
20) Confidence 0.67 Published 2005 Journal J Trauma Section Abstract Doc Link 15824646 Disease Relevance 0.72 Pain Relevance 0.34

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