INT86789

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 46
Total Number 48
Disease Relevance 30.66
Pain Relevance 25.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
microglia 16
nerve 6
spinal cord 3
hippocampus 3
brain 2
P2rx4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 344 100.00 Very High Very High Very High
Inflammation 199 100.00 Very High Very High Very High
Pyramidal cell 20 100.00 Very High Very High Very High
nociceptor 17 100.00 Very High Very High Very High
Central nervous system 215 99.96 Very High Very High Very High
Brush evoked pain 205 99.96 Very High Very High Very High
Dorsal horn 190 99.96 Very High Very High Very High
Neuropathic pain 513 99.84 Very High Very High Very High
sSRI 20 99.80 Very High Very High Very High
Spinal cord 265 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 415 99.98 Very High Very High Very High
Neuropathic Pain 944 99.96 Very High Very High Very High
Neurodegenerative Disease 120 99.74 Very High Very High Very High
Death 53 99.52 Very High Very High Very High
Frailty 20 99.52 Very High Very High Very High
Muscle Weakness 8 99.32 Very High Very High Very High
Inflammatory Pain 67 99.16 Very High Very High Very High
Convulsion 24 99.08 Very High Very High Very High
Ganglion Cysts 46 98.36 Very High Very High Very High
Pain 458 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, this is the first demonstration that P2X4R is expressed by microglia in the inflammatory pain.
Gene_expression (expressed) of P2X4R in microglia associated with ipn
1) Confidence 0.77 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15885314 Disease Relevance 0.48 Pain Relevance 0.51
Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain.
Gene_expression (Expression) of P2X4 receptor in microglia associated with inflammation and ipn
2) Confidence 0.77 Published 2005 Journal J. Neuroimmunol. Section Title Doc Link 15885314 Disease Relevance 0.42 Pain Relevance 0.82
We also found that the expression level of P2X4 was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade of P2X4 reversed the allodynia.
Gene_expression (expression) of P2X4 in spinal cord associated with nervous system injury, allodynia and spinal cord
3) Confidence 0.76 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.15 Pain Relevance 1.07
Here we report analysis of P2X4R expression following rat SCI.
Gene_expression (expression) of P2X4R associated with frailty
4) Confidence 0.70 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15885321 Disease Relevance 0.90 Pain Relevance 0.32
Spinal cord injury induces early and persistent lesional P2X4 receptor expression.
Gene_expression (expression) of P2X4 receptor in Spinal cord associated with spinal cord
5) Confidence 0.70 Published 2005 Journal J. Neuroimmunol. Section Title Doc Link 15885321 Disease Relevance 0.93 Pain Relevance 0.33
After nerve injury, P2X4R expression increased strikingly in the ipsilateral spinal cord, and P2X4Rs were induced in hyperactive microglia but not in neurons or astrocytes.
Gene_expression (expression) of P2X4R in neurons associated with nervous system injury and spinal cord
6) Confidence 0.64 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.43 Pain Relevance 0.96
The superficial layers of the spinal cord dorsal horn (DH) express P2X2, P2X4, and P2X6 subunits entering into the formation of ionotropic (P2X) receptors for ATP.
Gene_expression (express) of P2X4 in spinal cord dorsal horn associated with dorsal horn and spinal cord
7) Confidence 0.64 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10704486 Disease Relevance 0 Pain Relevance 0.37
Moreover, intrathecally administered antisense oligodeoxynucleotide for P2X4R reduced the expression of P2X4 protein in spinal microglia and prevented the development of the nerve injury-induced tactile allodynia.
Gene_expression (expression) of P2X4 in nerve associated with brush evoked pain and nervous system injury
8) Confidence 0.63 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.06 Pain Relevance 0.89
The expression of P2X4 protein, normally low in the naïve spinal cord, progressively increased in the days following nerve injury with a time course parallel to that of the development of tactile allodynia.
Gene_expression (expression) of P2X4 in nerve associated with brush evoked pain, nervous system injury and spinal cord
9) Confidence 0.63 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.03 Pain Relevance 0.91
Activated microglia in the spinal cord after nerve injury express ionotropic ATP receptors [e.g., P2X4 receptor (P2X4R) or P2X7R].
Gene_expression (express) of P2X4R in microglia associated with nervous system injury and spinal cord
10) Confidence 0.63 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.71 Pain Relevance 0.73
Activated microglia in the spinal cord after nerve injury express ionotropic ATP receptors [e.g., P2X4 receptor (P2X4R) or P2X7R].
Gene_expression (express) of P2X4 receptor in microglia associated with nervous system injury and spinal cord
11) Confidence 0.63 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.71 Pain Relevance 0.73
We investigated the P2X4 receptor (P2X4R) expression in the cervical spinal cord, trigeminal ganglion, and infraorbital nerve (ION), after a chronic constriction injury of unilateral ION and a treatment with selective serotonin reuptake inhibitor (SSRI).
Spec (investigated) Gene_expression (expression) of P2X4 receptor in ION associated with ganglion cysts, eae, trigeminal ganglion, injury, ssri and spinal cord
12) Confidence 0.60 Published 2010 Journal Neuroreport Section Abstract Doc Link 20407394 Disease Relevance 0.41 Pain Relevance 0.52
In injured and slightly injured ION, the P2X4R expression was significantly higher than in the naïve-rat ION.
Gene_expression (expression) of P2X4R in ION
13) Confidence 0.60 Published 2010 Journal Neuroreport Section Abstract Doc Link 20407394 Disease Relevance 0.44 Pain Relevance 0.65
A recent study has showed that SSRI inhibits P2X4R expression.
Gene_expression (expression) of P2X4R associated with ssri
14) Confidence 0.60 Published 2010 Journal Neuroreport Section Abstract Doc Link 20407394 Disease Relevance 0.44 Pain Relevance 0.64
We investigated the P2X4 receptor (P2X4R) expression in the cervical spinal cord, trigeminal ganglion, and infraorbital nerve (ION), after a chronic constriction injury of unilateral ION and a treatment with selective serotonin reuptake inhibitor (SSRI).
Spec (investigated) Gene_expression (expression) of P2X4R in ION associated with ganglion cysts, eae, trigeminal ganglion, injury, ssri and spinal cord
15) Confidence 0.60 Published 2010 Journal Neuroreport Section Abstract Doc Link 20407394 Disease Relevance 0.41 Pain Relevance 0.52
P2X4 receptor expression in a rat model of trigeminal neuropathic pain.
Gene_expression (expression) of P2X4 receptor associated with nociceptor and neuropathic pain
16) Confidence 0.60 Published 2010 Journal Neuroreport Section Title Doc Link 20407394 Disease Relevance 0.45 Pain Relevance 0.84
The expression of P2X4 receptors in the spinal cord is enhanced in spinal microglia after peripheral nerve injury, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain behaviour.
Gene_expression (expression) of P2X4 in spinal associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
17) Confidence 0.58 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096535 Disease Relevance 1.18 Pain Relevance 1.06
In naïve rats, intrathecal administration of cultured microglia that were preincubated with ATP to activate P2X4 produced tactile allodynia over the 3–5 h after the administration [10].
Gene_expression (produced) of P2X4 in microglia associated with brush evoked pain and intrathecal
18) Confidence 0.55 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.98 Pain Relevance 0.89
Moreover, it was found that reducing the expression of P2X4 protein in spinal microglia by means of intrathecally administered antisense oligodeoxynucleotide targeting P2X4R prevented the development of the nerve injury-induced tactile allodynia.
Gene_expression (expression) of P2X4 protein in microglia associated with brush evoked pain and nervous system injury
19) Confidence 0.44 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.08 Pain Relevance 0.76
The expression of P2X4 protein, normally low in the naive spinal cord, progressively increased in the days following nerve injury with a time-course parallel to that of the development of tactile allodynia.
Gene_expression (expression) of P2X4 protein in spinal cord associated with brush evoked pain, nervous system injury and spinal cord
20) Confidence 0.44 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.15 Pain Relevance 0.98

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